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Thyroid
Research Hotspot & Journal Scope - Targeting


Thyroid - DOI: 10.1089/thy.2018.0555
Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy

Christian M. Schürch · Matthias A. Roelli · Stefan Forster · Marie-Hélène Wasmer · Frido Brühl · Renaud Maire · Sergio Di Pancrazio · Marc-David Ruepp · Roland Giger · Aurel Perren · Anja Schmitt · Philippe Krebs · Roch-Philippe Charles · Matthias S. Dettmer ·

Medicine
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Thyroid - DOI: 10.1089/thy.2018.0399
Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha

Bernard Freudenthal · Samiksha Shetty · Natalie C. Butterfield · John G. Logan · Cho Rong Han · Xuguang Zhu · Inna Astapova · Anthony N. Hollenberg · Sheue-Yann Cheng · J.H. Duncan Bassett · Graham R. Williams ·

Biology Medicine
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Neuroactive peptides targeting the central nervous system through affinity with ion channels could provide insight leading to drug treatment of neurological diseases, which arise from ion channel dysfunctions.

Cnidarian peptide neurotoxins: a new source of various ion channel modulators or blockers against central nervous systems disease. [10.1016/j.drudis.2018.08.011]


In this review, we discuss pharmacological agents targeting epigenetic regulators.

Insights into novel emerging epigenetic drugs in myeloid malignancies [10.1177/2040620719866081]


Unexpectedly, virus attachment, internalization, and nuclear targeting were not disturbed in the KO cells.

Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection [10.1128/JVI.00972-19]


A library of unique CD38-targeting antibodies fused to deimmunized SLTA was screened in a variety of efficacy and safety models to identify TAK-169.

Abstract 2384: TAK-169, an exceptionally potent CD38 targeted engineered toxin body, as a novel direct cell kill approach for the treatment of multiple myeloma [10.1158/1538-7445.AM2019-2384]


In this perspective, we will overview most recently developed mitochondria-targeting peptides and peptidomimetics to outline the key aspects of structural requirement and design principle.

Mitochondria-targeting peptides and peptidomimetics: recent progress and design principles. [10.1021/acs.biochem.9b00857]


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