Thyroid

Research Hotspot & Journal Scope - Targeting

The hepatic targeting was achieved using covalently conjugated galactose (Gal), which is recognized by the asialoglycoprotein receptors specifically expressed in hepatocytes.

Compared with traditional targeting moiety simply paying attention to the ability to identify tumor cells and lacking capacity of leading drugs penetration into tumor tissue and cells, iRGD peptide overcomes this limitation and establishes a capability for tissue/cells-penetrating drug delivery [1,8].

Exploratory second-line treatments targeting resistance mechanisms as well as combination immunotherapy and chemotherapy in ongoing clinical trials are reviewed here.

For the purpose of synthesizing drug candidates with desirable bioactivity, a class of benzoyl amide containing nitrogen heterocyclic ring derivatives targeting VEGFR-2 was designed and screened out using Discovery Studio.

We address this issue by comparing the evolutionary trajectories towards antibiotic resistance of a Pseudomonas aeruginosa lasR defective mutant and its parental wild-type strain, when growing in presence of two ribosome-targeting antibiotics.