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Thyroid
Research Hotspot & Journal Scope - Targeting


Thyroid - DOI: 10.1089/thy.2018.0555
Targeting CD47 in Anaplastic Thyroid Carcinoma Enhances Tumor Phagocytosis by Macrophages and Is a Promising Therapeutic Strategy

Christian M. Schürch · Matthias A. Roelli · Stefan Forster · Marie-Hélène Wasmer · Frido Brühl · Renaud Maire · Sergio Di Pancrazio · Marc-David Ruepp · Roland Giger · Aurel Perren · Anja Schmitt · Philippe Krebs · Roch-Philippe Charles · Matthias S. Dettmer ·

Medicine
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Thyroid - DOI: 10.1089/thy.2018.0399
Genetic and Pharmacological Targeting of Transcriptional Repression in Resistance to Thyroid Hormone Alpha

Bernard Freudenthal · Samiksha Shetty · Natalie C. Butterfield · John G. Logan · Cho Rong Han · Xuguang Zhu · Inna Astapova · Anthony N. Hollenberg · Sheue-Yann Cheng · J.H. Duncan Bassett · Graham R. Williams ·

Biology Medicine
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The hepatic targeting was achieved using covalently conjugated galactose (Gal), which is recognized by the asialoglycoprotein receptors specifically expressed in hepatocytes.

The hepatic-targeted, resveratrol loaded nanoparticles for relief of high fat diet-induced nonalcoholic fatty liver disease. [10.1016/j.jconrel.2019.06.023]


Compared with traditional targeting moiety simply paying attention to the ability to identify tumor cells and lacking capacity of leading drugs penetration into tumor tissue and cells, iRGD peptide overcomes this limitation and establishes a capability for tissue/cells-penetrating drug delivery [1,8].

Curcumin nanocrystallites are an ideal nanoplatform for cancer chemotherapy [10.15761/fnn.1000186]


Exploratory second-line treatments targeting resistance mechanisms as well as combination immunotherapy and chemotherapy in ongoing clinical trials are reviewed here.

Second-line treatment of EGFR T790M-negative non-small cell lung cancer patients [10.1177/1758835919890286]


For the purpose of synthesizing drug candidates with desirable bioactivity, a class of benzoyl amide containing nitrogen heterocyclic ring derivatives targeting VEGFR-2 was designed and screened out using Discovery Studio.

Design, synthesis, biological evaluation of benzoyl amide derivatives containing nitrogen heterocyclic ring as potential VEGFR-2 inhibitors. [10.1016/j.bmc.2019.07.007]


We address this issue by comparing the evolutionary trajectories towards antibiotic resistance of a Pseudomonas aeruginosa lasR defective mutant and its parental wild-type strain, when growing in presence of two ribosome-targeting antibiotics.

Antibiotic resistance evolution is contingent on the quorum sensing response in Pseudomonas aeruginosa. [10.1093/molbev/msz144]


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