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New England Journal of Medicine
Research Hotspot & Journal Scope - Trial


New England Journal of Medicine - DOI: 10.1056/NEJMoa1808779
A Randomized Trial of E‐Cigarettes versus Nicotine‐Replacement Therapy

Peter Hajek · Anna Phillips‐Waller · Dunja Przulj · Francesca Pesola · Katie Myers Smith · Natalie Bisal · Jinshuo Li · Steve Parrott · Peter Sasieni · Lynne Dawkins · Louise Ross · Maciej Goniewicz · Qi Wu · Hayden J. McRobbie ·

Medicine
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New England Journal of Medicine - DOI: 10.1056/NEJMoa1901183
Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation.

Marco V Perez · Kenneth W Mahaffey · Haley Hedlin · John S Rumsfeld · Ariadna Garcia · Todd Ferris · Vidhya Balasubramanian · Andrea M Russo · Amol Rajmane · Lauren Cheung · Grace Hung · Justin Lee · Peter Kowey · Nisha Talati · Divya Nag · Santosh E Gummidipundi · Alexis Beatty · Mellanie True Hills · Sumbul Desai · Christopher B Granger · Manisha Desai · Mintu P Turakhia ·

Medicine
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New England Journal of Medicine - DOI: 10.1056/NEJMoa1901747
Trial of Satralizumab in Neuromyelitis Optica Spectrum Disorder.

Takashi Yamamura · Ingo Kleiter · Kazuo Fujihara · Jacqueline Palace · Benjamin Greenberg · Beata Zakrzewska-Pniewska · Francesco Patti · Ching-Piao Tsai · Albert Saiz · Hayato Yamazaki · Yuichi Kawata · Padraig Wright · Jerome De Seze ·

Medicine
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New England Journal of Medicine - DOI: 10.1056/NEJMoa1905795
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.

Jaideep Kapur · Jordan Elm · James M Chamberlain · William Barsan · James Cloyd · Daniel Lowenstein · Shlomo Shinnar · Robin Conwit · Caitlyn Meinzer · Hannah Cock · Nathan Fountain · Jason T Connor · Robert Silbergleit ·

Medicine
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New England Journal of Medicine - DOI: 10.1056/NEJMoa1904143
Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease.

Satoshi Yasuda · Koichi Kaikita · Masaharu Akao · Junya Ako · Tetsuya Matoba · Masato Nakamura · Katsumi Miyauchi · Nobuhisa Hagiwara · Kazuo Kimura · Atsushi Hirayama · Kunihiko Matsui · Hisao Ogawa ·

Medicine
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The building of ROC curves allowed us to establish that early measurements of global atrial strain could serve to predict  both the risk of failure to recover the atrial mechanical function and the one of AF relapses over a 12 month follow-up.

Atrial mechanical hypofunction after electrical cardioversion of persistent or long-lasting persistent atrial fibrillation: a retrospective cohort study. [10.4081/monaldi.2019.1178]


This process requires the analysis of genotype–phenotype relationships, and although genotyping tools are very advanced, phenotypic tools are not usually capable of satisfying the massive evaluation that is required to identify potential characters for bioethanol production in field trials.

High-Throughput Phenotyping of Bioethanol Potential in Cereals Using UAV-Based Multi-Spectral Imagery [10.3389/fpls.2019.00948]


Trial sequential analysis revealed that our meta-analysis had adequate power to support these results.

Impact of vertical versus horizontal vaginal cuff closure on vaginal length following hysterectomy: a meta-analysis of randomized trials [10.1007/s00192-019-03881-5]


The use of non-inferiority and superiority trials, and selection of appropriate and optimal study designs, remains a major challenge in the development, registration, and post-marketing implementation of new antibiotics.

Non-inferiority versus superiority trial design for new antibiotics in an era of high antimicrobial resistance: the case for post-marketing, adaptive randomised controlled trials. [10.1016/S1473-3099(19)30284-1]


PCA showed that Cu, Zn, Pb, and Cd as the first component were due to urbanization and agronomic practices, whereas As, Ni, and Cr as a second group were primarily of lithogenic origin, partly due to urbanization, and Hg was related to the atmospheric deposition of industrial waste gas.

Spatial distribution of soil trace element concentrations along an urban-rural transition zone in the black soil region of northeastern China [10.1007/s11368-019-02294-7]


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