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New England Journal of Medicine
Research Hotspot & Journal Scope - Prostate


New England Journal of Medicine - DOI: 10.1056/NEJMc1809961
Long-Term Effects of Finasteride on Prostate Cancer Mortality.

Phyllis J Goodman · Catherine M Tangen · Amy K Darke · M Scott Lucia · Leslie G Ford · Lori M Minasian · Howard L Parnes · Michael L LeBlanc · Ian M Thompson ·

Medicine
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New England Journal of Medicine - DOI: 10.1056/NEJMc1912868
Active Surveillance for Black Men with Low-Risk Prostate Cancer in the United States.

Bashir Al Hussein Al Awamlh · Xiaoyue Ma · Paul Christos · Jim C Hu · Jonathan E Shoag ·

Medicine
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New England Journal of Medicine - DOI: 10.1056/NEJMe1912750
Hormonal Therapy or Chemotherapy for Metastatic Prostate Cancer - Playing the Right CARD.

Mario A Eisenberger · Emmanuel S Antonarakis ·

Medicine
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New England Journal of Medicine - DOI: 10.1056/NEJMe1905891
Apalutamide for Metastatic, Hormone-Responsive Prostate Cancer.

Laurence Klotz ·

Medicine
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PSA was 7 ng/dl, DRE demonstrates a >100gr prostate gland.

Robotic simple prostatectomy plus panniculectomy and giant umbilical hernia repair [10.1590/S1677-5538.IBJU.2018.0565]


We investigated whether host or tumor GPR120 plays a role in the anti-prostate cancer effects of ω-3 FAs.

Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer [10.1093/jnci/djy125]


The European randomised study of screening for prostate cancer trial (ERSPC) and Prostate cancer intervention versus observation trial (PIVOT) indicate that overtreatment of the low risk prostate cancer is quite common.

Active surveillance: transperineal biopsies and evaluation of multi-parametric magnetic resonance imaging [10.18203/2349-2902.isj20194405]


SIGNIFICANCE: This study delineates the molecular mechanisms by which cholesterol increases prostate cancer progression and demonstrates that the binding of cholesterol-induced APMAP with EPS15R inhibits EGFR internalization and activates ERK1/2 to promote EMT.

Cholesterol Induces Epithelial-to-Mesenchymal Transition of Prostate Cancer Cells by Suppressing Degradation of EGFR through APMAP. [10.1158/0008-5472.CAN-18-3295]


Introduction: We compared the diagnostic accuracy of percentage free prostate-specific antigen (PSA), multiparametric magnetic resonance imaging (mpMRI), and gallium-68 prostate-specific membrane antigen positron emission tomography (Ga-PSMA PET) to detect cancer prostate in men with PSA between 4 and 20 ng/ml in prebiopsy settings.

Comparison of percentage free PSA, MRI and GaPSMA PET scan for diagnosing cancer prostate in men with PSA between 4 and 20 ng/ml [10.4103/iju.IJU_91_19]


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