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Pancreas
Research Hotspot & Journal Scope - Kinase


Pancreas - DOI: 10.1097/MPA.0000000000001321
Inhibition of LONP1 Suppresses Pancreatic Cancer Progression Via c-Jun N-Terminal Kinase Pathway–Meditated Epithelial-Mesenchymal Transition

Can Liu · Hai Wang · Hao Li · Xiong Chen · Xiang Wu · Bin Lu · Wenling Zhang · Yong Zhou · Gary Guishan Xiao · Ge Gao ·

Chemistry Medicine
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Pancreas - DOI: 10.1097/MPA.0000000000001247
Correlation of Serum and Ascitic Fluid Soluble Form Urokinase Plasminogen Activator Receptor Levels With Patient Complications, Disease Severity, Inflammatory Markers, and Prognosis in Patients With Severe Acute Pancreatitis

Ding Long · Yujun Wang · Hui Wang · Xiaoling Wu · Li Yu ·

Medicine
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Pancreas - DOI: 10.1097/MPA.0000000000001248
Expression and Clinical Significance of Protein Kinase RNA–Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2&agr; in Pancreatic Ductal Adenocarcinoma

Eric M Wang · Hironari Akasaka · Jun Zhao · Gauri R Varadhachary · Jeffrey E Lee · Anirban Maitra · Jason B Fleming · Mien-Chie Hung · Huamin Wang · Matthew H G Katz ·

Biology Medicine
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Referring to their X-ray crystal structure with FES proto-oncogene tyrosine kinase, as a surrogate of FER followed by chemical modification including scaffold hopping of the pyridine template, we discovered pyrido-pyridazinone derivatives with potent FER kinase inhibitory activity.

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity. [10.1021/ACSMEDCHEMLETT.8B00631]


Abbreviations ACTB: actin, beta; ADP: adenosine diphosphate; AMP: adenosine monophosphate; AMPK: AMP-activated protein kinase; ARMC8: armadillo repeat containing 8; ATP: adenosine triphosphate; BafA1: bafilomycin A1; BCAA: branched chain amino acid; BICC1: BicC family RNA binding protein 1; BSA: bovine serum albumin; CAMKK2 kinase: calcium/calmodulin dependent protein kinase kinase 2, beta; CHX: cycloheximide; DMEM: Dulbecco’s modified Eagle’s medium; E1: ubiquitin-activating enzyme; E2: ubiquitin-conjugating enzyme; E3: ubiquitin ligase; ECAR: extracellular acidification rate; FACS: fluorescent associated cell sorter; FBP1: fructose-bisphosphatase 1; FCCP: carbonyl cyanide-4 (trifluoromethoxy) phenylhydrazone; G6P: glucose-6-phosphate; GDP: guanosine diphosphate; GFP: green fluorescent protein; GID: glucose induced degradation deficient; GMP: guanosine monophosphate; GTP: guanosine triphosphate; HBP1: high mobility group box transcription factor 1; HPRT: hypoxanthine guanine phosphoribosyl transferase; KO: knock out; LE: long exposure; MAEA: macrophage erythroblast attacher; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MKLN1: muskelin 1; mRNA: messenger RNA; MTOR: mechanistic target of rapamycin; NES: normalized enrichment score; OCR: oxygen consumption rate; PBS: phosphate buffered saline; PCK1: phosphoenolpyruvate carboxykinase 1, cytosolic; PCR: polymerase chain reaction; PFA: paraformaldehyde; RANBP9: RAN binding protein 9; RING: really interesting new gene; RMND5: required for meiotic nuclear division5 homolog; RPS6: ribosomal protein S6; RPTOR: regulatory associated protein of MTOR, complex 1; SE: short exposure; SEM: standard error of the mean; SQSTM1/p62: sequestosome 1; TSC2: tuberous sclerosis complex 2; TUBA4A: tubulin; TUBE: tandem ubiquitin binding entities; Ub: ubiquitin; UPS: ubiquitin proteasome system; WDR26: WD repeat domain 26; WT: wild type.

The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan [10.1080/15548627.2019.1695399]


Kinases inhibitors are widely used and their efficiency for the treatment of cancers has been demonstrated.

Kinome expression profiling to target new therapeutic avenues in multiple myeloma [10.3324/haematol.2018.208306]


Expression of Glucose-6-Phosphatase and Glucokinase genes in liver samples from each group were normalized with housekeeping gene (s-actin) using reverse transcriptase real time Polymerase chain reaction.

The Hypoglycemic Effects of Ginger and Garlic Administration on Induced Diabetic Rats [10.21608/ZVJZ.2019.9557.1023]


More amounts of PTEN-induced putative kinase protein 1 (PINK1) and Parkin translocated onto the mitochondria were detected in the high-dose TXL group than in the MIRI group (P<0.

Tongxinluo Ameliorates Myocardial Ischemia-Reperfusion Injury Mainly via Activating Parkin-Mediated Mitophagy and Downregulating Ubiquitin-Proteasome System [10.1007/s11655-019-3166-8]


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