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PLoS ONE
Research Hotspot & Journal Scope - vitro


PLoS ONE - DOI: 10.1371/journal.pone.0210530
Determinants of corrosion resistance of Ti-6Al-4V alloy dental implants in an In Vitro model of peri-implant inflammation

Larissa O Berbel · Everson do P Banczek · Ioannis K Karoussis · Georgios A Kotsakis · Isolda Costa ·

Materials Science Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0208611
Purification, characterization and in vitro and in vivo immune enhancement of polysaccharides from mulberry leaves

Xiaolan Chen · Zhicun Sheng · Shulei Qiu · Haifeng Yang · Jiping Jia · Jing Wang · Chunmao Jiang ·

Chemistry Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0210508
In vitro and in vivo properties of the bovine antimicrobial peptide, Bactenecin 5

R L Price · L Bugeon · S Mostowy · C Makendi · B W Wren · H D Williams · S J Willcocks ·

Biology Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0218740
Hyaluronic Acid (HA), Platelet-Rich Plasm and Extracorporeal Shock Wave Therapy (ESWT) promote human chondrocyte regeneration in vitro and ESWT-mediated increase of CD44 expression enhances their susceptibility to HA treatment

Mario Vetrano · Danilo Ranieri · Monica Nanni · Antonio Pavan · Florence Malisan · Maria Chiara Vulpiani · Vincenzo Visco ·

Chemistry Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0213049
Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia

Hajer Tlili · Najjaa Hanen · Abdelkerim Ben Arfa · Mohamed Neffati · Abdelbasset Boubakri · Daniela Buonocore · Maurizia Dossena · Manuela Verri · Enrico Doria ·

Biology Medicine
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This method is a powerful tool for in vitro T cell lineage generation and will facilitate the development of in vitro derived T cells for use in regenerative medicine and cell-based therapies.

Using Human Induced Pluripotent Stem Cells for the Generation of Tumor Antigen-specific T Cells. [10.3791/59997]


Using a panel of human mammary epithelial HME1 cell lines that share a common protein signature, and develop in vitro three dimensional (3D) “DCIS-like” amorphous structures, we identified by bioinformatics analysis protein-miRNA pairs, potentially involved in mammary morphogenetic mechanisms, including the ANXA8 mechanism.

3D Mammary Epithelial Cell Models: A Goldmine of DCIS Biomarkers and Morphogenetic Mechanisms [10.3390/cancers11020130]


Initiatives to replace, reduce and refine animal testing have led to developments of new methodologies utilizing organotypic, in vitro tissue models.

Toxicological comparison of cigarette smoke and e‐cigarette aerosol using a 3D in vitro human respiratory model [10.1016/j.yrtph.2019.01.036]


In the present work, comparative analysis of in vitro callus induction and regeneration efficiency of eight indigenous aromatic rice cultivars, viz.

Comparative Analyses of Regeneration Potentiality of Eight Indigenous Aromatic Indica rice (Oryza sativa L.) Varieties [10.26438/ijsrbs/v6i1.5564]


The safety assessment of 3′‐SL comprised in vitro genotoxicity tests and a 90‐day oral (gavage) toxicity study.

Toxicological safety assessment of the human‐identical milk oligosaccharide 3′‐sialyllactose sodium salt [10.1002/jat.3824]


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