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PLoS ONE
Research Hotspot & Journal Scope - human


PLoS ONE - DOI: 10.1371/journal.pone.0210077
The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma

S Di Matteo · L Nevi · D Costantini · D Overi · G Carpino · S Safarikia · F Giulitti · C Napoletano · E Manzi · A M De Rose · F Melandro · M Bragazzi · P B Berloco · F Giuliante · G Grazi · A Giorgi · V Cardinale · L Adorini · E Gaudio · D Alvaro ·

Chemistry Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0219850
Mapping human mobility during the third and second millennia BC in present-day Denmark

Karin Margarita Frei · Sophie Bergerbrant · Karl-Göran Sjögren · Marie Louise Jørkov · Niels Lynnerup · Lise Harvig · Morten E Allentoft · Martin Sikora · T Douglas Price · Robert Frei · Kristian Kristiansen ·

Geography Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0214229
The 2017 human monkeypox outbreak in Nigeria—Report of outbreak experience and response in the Niger Delta University Teaching Hospital, Bayelsa State, Nigeria

Dimie Ogoina · James Hendris Izibewule · Adesola Ogunleye · Ebi Ederiane · Uchenna Anebonam · Aworabhi Neni · Abisoye Oyeyemi · Ebimitula Nicholas Etebu · Chikwe Ihekweazu ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0217170
Human colon function ex vivo: Dependence on oxygen and sensitivity to antibiotic

Luke A Schwerdtfeger · Nora Jean Nealon · Elizabeth P Ryan · Stuart A Tobet ·

Chemistry Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0206484
Baseline human gut microbiota profile in healthy people and standard reporting template

Charles H King · Hiral Desai · Allison C Sylvetsky · Jonathan LoTempio · Shant Ayanyan · Jill Carrie · Keith A Crandall · Brian C Fochtman · Lusine Gasparyan · Naila Gulzar · Paul Howell · Najy Issa · Konstantinos Krampis · Lopa Mishra · Hiroki Morizono · Joseph R Pisegna · Shuyun Rao · Yao Ren · Vahan Simonyan · Krista Smith · Sharanjit VedBrat · Michael D Yao · Raja Mazumder ·

Biology Medicine
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The CNS control is applied to multi-joints coordination relating to the problem of human postural balance.

Imitation of CNS-Control of Human Lower Limb: Joints Simulation* [10.1109/ICSC47195.2019.8950534]


5 years) in sodium heparin tubes and incubated without or with recombinant human interferon alpha 2b (rhIFNα, 2 IU/ml, 4 hrs, 37C°, 5% CO2).

THU0511 COMPARISON OF PAXGENE AND TEMPUS WHOLE BLOOD RNA COLLECTION AND ISOLATION SYSTEMS FOR THE QUANTIFICATION OF TYPE I INTERFERON-STIMULATED GENE EXPRESSION [10.1136/annrheumdis-2019-eular.4316]


2,3 We have developed a fully human therapeutic monoclonal an‐ tibody (mAb), CSL311, with specificity for the common cytokine binding site of the human βc receptor.

Anti‐βc mAb CSL311 inhibits human nasal polyp pathophysiology in a humanized mouse xenograft model [10.1111/all.14041]


4 m/s); (2) identifies the root causes of inaccurate foot trajectory estimates obtained from the ZUPT method; and (3) offers important engineering recommendations for selecting accurate IMUs for studying human running.

Effect of IMU Design on IMU-Derived Stride Metrics for Running [10.3390/s19112601]


In SW1116 and HCT116 human colon cancer cells with KRAS mutations, treatment with Ab3‐8 reduced intracellular glutamine transport, phosphorylation of AKT and ERK, and inhibited in vivo tumor growth of these cells in athymic mice.

Anti‐tumor effects of an antagonistic mAb against the ASCT2 amino acid transporter on KRAS‐mutated human colorectal cancer cells [10.1002/cam4.2689]


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