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PLoS ONE
Research Hotspot & Journal Scope - expression


PLoS ONE - DOI: 10.1371/journal.pone.0224396
Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression

Kristina Hasakova · Richard Reis · Marian Vician · Michal Zeman · Iveta Herichova ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0212127
Leukemia multiclass assessment and classification from Microarray and RNA-seq technologies integration at gene expression level

Daniel Castillo · Juan Manuel Galvez · Luis J Herrera · Fernando Rojas · Olga Valenzuela · Octavio Caba · Jose Prados · Ignacio Rojas ·

Computer Science Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0215955
Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats

Vincenzo Migliaccio · Rosaria Scudiero · Raffaella Sica · Lillà Lionetti · Rosalba Putti ·

Chemistry Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0216071
Comprehensive genomic survey, structural classification and expression analysis of C2H2 zinc finger protein gene family in Brassica rapa L.

Intikhab Alam · Khadija Batool · Dong-Li Cui · Yan-Qing Yang · Yun-Hai Lu ·

Biology Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0216463
Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models

Kayla A Chase · Benjamin Feiner · Marcia J Ramaker · Edward Hu · Cherise Rosen · Rajiv P Sharma ·

Biology Medicine
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Tumor necrosis factor (TNF)‐α and interferon (IFN)‐γ, the expression levels of which have been reported to be elevated in lesional skin of patients with vitiligo, synergistically upregulated Fas expression on human melanocytes but inhibited the Fas‐mediated apoptosis.

Fas‐FasL interaction in cytotoxic T cell‐mediated vitiligo: The role of lesional expression of tumor necrosis factor‐α and interferon‐γ in Fas‐mediated melanocyte apoptosis [10.1111/exd.14053]


The effectR package relies on a combination of regular expressions statements and hidden Markov model approaches to predict candidate RxLR and CRN effectors.

effectR: An expandable R package to predict candidate RxLR and CRN effectors in oomycetes using motif searches. [10.1094/MPMI-10-18-0279-TA]


Gene expression measurements by RNA-seq along a time course revealed the strongest transcriptomic response 24 h after inoculation in the resistant genotype.

Resistant and susceptible cacao genotypes exhibit defense gene polymorphism and unique early responses to Phytophthora megakarya inoculation [10.1007/s11103-019-00832-y]


These results suggest that LH2171 induces A20 expression via TLR2 signaling, inhibiting the activation of NF-κB/MAPKs and cytokine production in antigen-presenting cells.

Lactobacillus helveticus SBT2171 Induces A20 Expression via Toll-Like Receptor 2 Signaling and Inhibits the Lipopolysaccharide-Induced Activation of Nuclear Factor-kappa B and Mitogen-Activated Protein Kinases in Peritoneal Macrophages [10.3389/fimmu.2019.00845]


Modification of aquaporin expression and/or subcellular localization may be involved in the pathogenesis of pancreatic insufficiencies, diabetes and pancreatic cancer.

Aquaporins Involvement in Pancreas Physiology and in Pancreatic Diseases [10.3390/ijms20205052]


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