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PLoS ONE
Research Hotspot & Journal Scope - expression


PLoS ONE - DOI: 10.1371/journal.pone.0224396
Expression of miR-34a-5p is up-regulated in human colorectal cancer and correlates with survival and clock gene PER2 expression

Kristina Hasakova · Richard Reis · Marian Vician · Michal Zeman · Iveta Herichova ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0212127
Leukemia multiclass assessment and classification from Microarray and RNA-seq technologies integration at gene expression level

Daniel Castillo · Juan Manuel Galvez · Luis J Herrera · Fernando Rojas · Olga Valenzuela · Octavio Caba · Jose Prados · Ignacio Rojas ·

Computer Science Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0215955
Oxidative stress and mitochondrial uncoupling protein 2 expression in hepatic steatosis induced by exposure to xenobiotic DDE and high fat diet in male Wistar rats

Vincenzo Migliaccio · Rosaria Scudiero · Raffaella Sica · Lillà Lionetti · Rosalba Putti ·

Chemistry Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0216071
Comprehensive genomic survey, structural classification and expression analysis of C2H2 zinc finger protein gene family in Brassica rapa L.

Intikhab Alam · Khadija Batool · Dong-Li Cui · Yan-Qing Yang · Yun-Hai Lu ·

Biology Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0216463
Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models

Kayla A Chase · Benjamin Feiner · Marcia J Ramaker · Edward Hu · Cherise Rosen · Rajiv P Sharma ·

Biology Medicine
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In addition to providing a favorable microenvironment for cellular adhesion and proliferation, FTY/MBG-PLGA scaffolds significantly facilitated the in vitro osteogenic differentiation of rBMSCs and also markedly stimulated the upregulation of Hif-1α expression via the activation of the Erk1/2 pathway, which mediated the osteogenic and pro-angiogenic effects on rBMSCs.

Supercritical CO2 foamed composite scaffolds incorporating bioactive lipids promote vascularized bone regeneration via Hif-1α upregulation and enhanced type H vessel formation. [10.1016/j.actbio.2019.05.066]


singleCellHaystack is implemented as an R package, and includes additional functions for clustering and visualization of genes with interesting expression patterns.

singleCellHaystack: Finding surprising genes in 2-dimensional representations of single cell transcriptome data [10.1101/557967]


The exact function expression of the magnetic field is obtained and the relevant factors are analyzed in detail.

Magnetic field analysis of solenoid driven by alternating current [10.1088/1742-6596/1237/3/032073]


We apply the method to gene expression data of breast cancer patients, and confirm the crucial importance of the ESR1 gene in differentiating estrogen receptor status.

Sparse quadratic classification rules via linear dimension reduction [10.1016/j.jmva.2018.09.011]


The lesion-related mRNA expression and secretion of VEGF-A and PGF by mononuclear phagocytes were potently suppressed by PGF and partially by VEGF-A inhibition.

Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina [10.1186/s12974-019-1419-2]


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