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PLoS ONE
Research Hotspot & Journal Scope - chronic


PLoS ONE - DOI: 10.1371/journal.pone.0208506
Safety and efficacy of glecaprevir/pibrentasvir for the treatment of chronic hepatitis C in patients aged 65 years or older

Graham R Foster · Tarik Asselah · Sarah Kopecky-Bromberg · Yang Lei · Armen Asatryan · Roger Trinh · Neddie Zadeikis · Federico J Mensa ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0218249
Challenges and strategies in patients’ health priorities-aligned decision-making for older adults with multiple chronic conditions

Mary Tinetti · Lilian Dindo · Cynthia Daisy Smith · Caroline Blaum · Darce Costello · Gregory Ouellet · Jonathan Rosen · Kizzy Hernandez-Bigos · Mary Geda · Aanand Naik ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0211343
Depression and anxiety in patients with different rare chronic diseases: A cross-sectional study

Natalie Uhlenbusch · Bernd Löwe · Martin Härter · Christoph Schramm · Christina Weiler-Normann · Miriam K Depping ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0209654
Capacity and willingness to use information technology for managing chronic diseases among patients: A cross-sectional study in Lahore, Pakistan

Sadia Iftikhar · Anum Saqib · Muhammad Rehan Sarwar · Muhammad Sarfraz · Mosab Arafat · Qurat-Ul-Ain Shoaib ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0213192
Hyperkalemia and renin-angiotensin aldosterone system inhibitor therapy in chronic kidney disease: A general practice-based, observational study

Min Jun · Meg J Jardine · Vlado Perkovic · Quentin Pilard · Laurent Billot · Anthony Rodgers · Kris Rogers · Martin Gallagher ·

Medicine
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Hidradenitis suppurativa is a painful chronic inflammatory skin condition characterized by inflammatory nodules that can lead to sinus tracts and scarring.

Combination hyperbaric oxygen therapy and ustekinumab for severe hidradenitis suppurativa [10.1111/pde.13775]


Conclusion: These data demonstrate IL-21-based gene and cellular therapies as valid candidates for treating chronic HBV infections, with potential in removing cccDNA-harboring hepatocytes via activated CD8+ T cells accompanied by long-term protective memory.

IL-21-based therapies induce clearance of hepatitis B virus persistence in mouse models [10.7150/thno.35331]


Objective To investigate the effect of continuous nursing care on quality of life, self-care ability, and readmission rate in patients with stable chronic heart failure.

Effect of continuous nursing care on quality of life in patients with chronic heart failure at stable stage [10.3760/CMA.J.ISSN.1007-1245.2019.05.047]


Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema, and nearly 35% patients respond poorly to non‐sedating H1 antihistamine treatment.

C‐reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level [10.1111/exd.13874]


To explore the loss of suppressive cytokines exclusively during the chronic phase of infection, we blocked IL-10R in chronically infected mice.

IL-10 and ICOS Differentially Regulate T Cell Responses in the Brain during Chronic Toxoplasma gondii Infection [10.4049/jimmunol.1801229]


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