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PLoS ONE
Research Hotspot & Journal Scope - cells


PLoS ONE - DOI: 10.1371/journal.pone.0211347
Label-free classification of cells based on supervised machine learning of subcellular structures

Yusuke Ozaki · Hidenao Yamada · Hirotoshi Kikuchi · Amane Hirotsu · Tomohiro Murakami · Tomohiro Matsumoto · Toshiki Kawabata · Yoshihiro Hiramatsu · Kinji Kamiya · Toyohiko Yamauchi · Kentaro Goto · Yukio Ueda · Shigetoshi Okazaki · Masatoshi Kitagawa · Hiroya Takeuchi · Hiroyuki Konno ·

Computer Science Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0217304
Physical events occurring during the cryopreservation of immortalized human T cells

Julie Meneghel · Peter Kilbride · John G Morris · Fernanda Fonseca ·

Chemistry Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0224132
Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells

Paule Bénit · Agathe Kahn · Dominique Chretien · Sylvie Bortoli · Laurence Huc · Manuel Schiff · Anne-Paule Gimenez-Roqueplo · Judith Favier · Pierre Gressens · Malgorzata Rak · Pierre Rustin ·

Biology Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0224015
TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo

Kristina Petrovic · Joseph Robinson · Katharine Whitworth · Elizabeth Jinks · Abeer Shaaban · Steven P Lee ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0222767
Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling

Larisa V Smolyaninova · Alexandra A Shiyan · Leonid V Kapilevich · Alexander V Lopachev · Tatiana N Fedorova · Tatiana S Klementieva · Aleksey A Moskovtsev · Aslan A Kubatiev · Sergei N Orlov ·

Chemistry Medicine
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BackgroundThe signaling pathway of epithelial to mesenchymal transition (EMT) is regulated by c-Src kinase in many cells.

The effects of c-Src kinase on EMT signaling pathway in human lens epithelial cells associated with lens diseases [10.1186/s12886-019-1229-4]


Here, we explored the molecular mechanism of the capsaicin-induced antitumor effects on ESCC Eca109 cells.

Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression [10.1042/BSR20190819]


Here, we show that epigenetic silencing of NDRG4 modulates integrin signaling by assembling β1-integrins into large punctate clusters at the leading edge of tumor cells to promote an “adhesive switch,” decreasing cell adhesion to fibronectin and increasing cell adhesion and migration towards vitronectin, an important component of human lymph nodes.

NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients [10.1038/s41523-019-0106-x]


Then, six variants were selected and the individual scFv gene was synthesized in the VL and VH domains and expressed in Chinese hamster ovary cells.

Novel single‐chain variant of antibody against mesothelin established by phage library [10.1111/cas.14150]


Our data showed that higenamine ameliorated oxygen‐glucose deprivation/reperfusion (OGD/R)‐induced neuronal cells injury.

Higenamine protects neuronal cells from oxygen‐glucose deprivation/reoxygenation‐induced injury [10.1002/jcb.27656]


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