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PLoS ONE
Research Hotspot & Journal Scope - breast


PLoS ONE - DOI: 10.1371/journal.pone.0213292
A clinical decision support system learned from data to personalize treatment recommendations towards preventing breast cancer metastasis

Xia Jiang · Alan Wells · Adam Brufsky · Richard Neapolitan ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0215894
Involvement of miR-770-5p in trastuzumab response in HER2 positive breast cancer cells

Senem Noyan · Hakan Gurdal · Bala Gur Dedeoglu ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0215948
Breast cancer prognosis is better in patients who develop subsequent metachronous thyroid cancer

Kefeng Lei · Xujun He · Leibo Yu · Chao Ni · Hailong Chen · Dandan Guan · Kewang Sun · Hai Zou ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0225129
Plasma metabolites as possible biomarkers for diagnosis of breast cancer

Jiwon Park · Yumi Shin · Tae Hyun Kim · Dong-Hyun Kim · Anbok Lee ·

Medicine
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PLoS ONE - DOI: 10.1371/journal.pone.0209010
Genetic variants in genes related to inflammation, apoptosis and autophagy in breast cancer risk

Johanna M Schuetz · Anne Grundy · Derrick G Lee · Agnes S Lai · Lindsay C Kobayashi · Harriet Richardson · Jirong Long · Wei Zheng · Kristan J Aronson · John J Spinelli · Angela R Brooks-Wilson ·

Medicine
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MATERIALS AND METHODS In this retrospective study, 264 benign lesions and 390 luminal A breast cancers were automatically segmented from dynamic contrast-enhanced breast magnetic resonance images.

Additive Benefit of Radiomics Over Size Alone in the Distinction Between Benign Lesions and Luminal A Cancers on a Large Clinical Breast MRI Dataset. [10.1016/j.acra.2018.04.019]


Triple‐negative breast cancer (TNBC) is an aggressive subtype of epithelial breast malignancy, and chemoresistance is the major obstacle for cancer therapy.

Hypoxia‐induced tRNA‐derived fragments, novel regulatory factor for doxorubicin resistance in triple‐negative breast cancer [10.1002/jcp.27533]


In pilot study, we found that the expression of HIF-1α significantly increased in breast cancer cell lines and tissue samples with higher malignant behaviors and decreased in luminal subtype breast cancer cells and tissue samples.

Hypomethylation at non-CpG/CpG sites in the promoter of HIF-1α gene combined with enhanced H3K9Ac modification contribute to maintain higher HIF-1α expression in breast cancer [10.1038/s41389-019-0135-1]


&NA; The muscle syndrome woody breast (WB) impairs quality of chicken fillets and is a challenge to the poultry meat industry.

Near‐infrared spectroscopy detects woody breast syndrome in chicken fillets by the markers protein content and degree of water binding [10.3382/ps/pey351]


Functionally, reducing m6A expression by overexpressing METTL14 and/or knockdown of ALKBH5 could inhibit breast cell viability, colony formation and cell migration.

Changes of N6-methyladenosine modulators promote breast cancer progression [10.1186/s12885-019-5538-z]


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