Journal of Neural Transmission

Research Hotspot & Journal Scope - transporter

Solute Carriers (SLCs) represent the largest family of transmembrane transporters in humans and constitute major determinants of cellular metabolism.

The miR‐8‐3p mimic upregulated expression of glucose transporter 3, lactate dehydrogenase A and monocarboxylate transporter 1, and increased lactic acid dehydrogenase activity, lactate secretion, and ATP depletion in SCs; the miR‐8‐3p inhibitor had the opposite effects on these parameters.

This review will shed light on current status of excipients, which can be used to modulate membrane transporter inhibition potential and discuss the mechanism involved in it.

Finally, levetiracetam has no effect on the expression, or function of the products of the ABC transporter genes, ABCB1 (coding for P-gp), ABCC1, ABCC2, and ABCG2, in human cell lines.

ATP-binding cassette (ABC) transporter proteins have important functions in bacteria to maintain survival and homeostasis.