Journal of Neural Transmission

Research Hotspot & Journal Scope - transporter

The side population assay exploits the ability of some cells to efflux Hoechst dye via ATP-binding cassette transporters.

The Mla phospholipid transporter is a multi-subunit ATP-binding cassette transport system widely understood to move phospholipids in a retrograde direction; that is, from the outer membrane to the inner membrane.

At present, two major hypotheses of drug resistance in epilepsy have been put forward, although there is ongoing debate [3]: (1) the ‘‘drug-transporter hypothesis’’, in which AEDs are removed from epileptogenic tissue through the overexpression of multidrug transporters such as P-glycoprotein and multidrug resistance-associated proteins; and (2) the ‘‘target hypothesis’’, in which drug-target sensitivity declines in epileptogenic brain regions.

This review will shed light on current status of excipients, which can be used to modulate membrane transporter inhibition potential and discuss the mechanism involved in it.

His talk was followed by BControl of glycine receptor activation by glycine transporters co-expressed in Xenopus oocytes^, given by Diba Sheipouri, University of Sydney, and coauthored by R.