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Journal of Integrative Medicine
Research Hotspot & Journal Scope - toxicity


Journal of Integrative Medicine - DOI: 10.1016/J.JOIM.2019.03.006
Interactive antimicrobial and toxicity profiles of Pittosporum angustifolium Lodd. extracts with conventional antimicrobials.

Baxter Blonk · Ian E Cock ·

Chemistry Medicine
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Journal of Integrative Medicine - DOI: 10.1016/j.joim.2019.02.001
Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development.

Carlos R Oliveira · Daniel G Spindola · Daniel M Garcia · Adolfo Erustes · Alexandre Bechara · Caroline Palmeira-Dos-Santos · Soraya S Smaili · Gustavo J S Pereira · André Hinsberger · Ezequiel P Viriato · Maria Cristina Marcucci · Alexandra C H F Sawaya · Samantha L Tomaz · Elaine G Rodrigues · Claudia Bincoletto ·

Chemistry Medicine
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Journal of Integrative Medicine - DOI: 10.1016/j.joim.2018.11.008
Telfairia occidentalis (Cucurbitaceae) pulp extract mitigates rifampicin-isoniazid-induced hepatotoxicity in an in vivo rat model of oxidative stress.

Lucky Legbosi Nwidu · Yibala Ibor Oboma ·

Medicine
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Journal of Integrative Medicine - DOI: 10.1016/J.JOIM.2019.07.002
Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum (Asteraceae) in male Wistar rats.

Pierre Watcho · Ismaelle Rosine Mpeck · Patrick Brice Deeh Defo · Modeste Wankeu-Nya · Esther Ngadjui · Georges Romeo Bonsou Fozin · Pierre Kamtchouing · Albert Kamanyi ·

Medicine
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When fish were the most sensitive trophic level, different compounds were identified as the most toxic in FET and to AFT tests; however, the differences were not so large that they resulted in substantially different outcomes when potencies were binned using the United Nations categories of aquatic toxicity under the Globally Harmonized System for classification and labeling.

Fish embryo tests and acute fish toxicity tests are interchangeable in the application of the threshold approach. [10.1002/etc.4351]


The Organisation for Economic Co-Operation and Development (OECD) coordinates international efforts to enhance developmental neurotoxicity (DNT) testing.

International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing [10.1093/toxsci/kfy211]


Bisphenol A (BPA), an endocrine-disrupting chemical, is capable of producing reproductive toxicity.

1,25-Dihydroxyvitamin D3 modulates the effects of sublethal BPA on mitochondrial function via activating PI3K-Akt pathway and 17β-estradiol secretion in rat granulosa cells [10.1016/j.jsbmb.2018.09.002]


During the last two decades the micronucleus (MN) test has been extensively used as a genotoxicity screening tool of chemicals and in a variety of exploratory and mechanistic investigations.

Micronucleus Analysis by Flow Cytometry. [10.1007/978-1-4939-9646-9_9]


Additionally, animal studies investigating a higher dosage, its combination with other pharmacological compounds and associated metabolic comorbidities are recommended, as cases of hepatotoxicity associated with the consumption of green tea extract have been reported.

Psychotropic effects of L-theanine and its clinical properties: from the management of anxiety and stress to a potential use in schizophrenia. [10.1016/j.phrs.2019.104395]


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