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Journal of Diabetes Research
Research Hotspot & Journal Scope - Pathway


Journal of Diabetes Research - DOI: 10.1155/2019/4021623
Visfatin Induces Inflammation and Insulin Resistance via the NF-κB and STAT3 Signaling Pathways in Hepatocytes

Yu Jung Heo · Sung-E Choi · Ja Young Jeon · Seung Jin Han · Dae Jung Kim · Yup Kang · Kwan Woo Lee · Hae Jin Kim ·

Chemistry Medicine
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Journal of Diabetes Research - DOI: 10.1155/2019/8712492
Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways

Xiandong Zhu · Feixia Guo · Hengjie Tang · Chongchu Huang · Gangyin Xie · Tingting Huang · Yonglin Li · Chengyang Liu · Hongwei Wang · Bicheng Chen ·

Medicine
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Journal of Diabetes Research - DOI: 10.1155/2019/2981705
Effect of Baoshenfang Formula on Podocyte Injury via Inhibiting the NOX-4/ROS/p38 Pathway in Diabetic Nephropathy

Fang-qiang Cui · Long Tang · Yan-bin Gao · Yue-fen Wang · Yuan Meng · Cun Shen · Zi-long Shen · Zhi-qiang Liu · Wen-jing Zhao · Wei Jing Liu ·

Medicine Chemistry
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Journal of Diabetes Research - DOI: 10.1155/2019/5920676
Platelet-Rich Plasma with Endothelial Progenitor Cells Accelerates Diabetic Wound Healing in Rats by Upregulating the Notch1 Signaling Pathway

Cheng Zhang · Yu Zhu · Shengdi Lu · Wanrun Zhong · Yanmao Wang · Yimin Chai ·

Medicine
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Journal of Diabetes Research - DOI: 10.1155/2019/4650906
To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway

Jia-Rong Gao · Xiu-Juan Qin · Zhao-Hui Fang · Li-Shan · Li-Ping Han · Hui-Jiang · Ming-Fei Guo · Nan-Nan Jiang ·

Medicine
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A cortical-to-subcortical hierarchy is postulated whereby GPFA rapidly propagates from prefrontal cortex to the brainstem via extrapyramidal corticoreticular pathways, whereas the thalamus is engaged secondarily.

The epileptic network of Lennox-Gastaut syndrome [10.1212/WNL.0000000000007775]


In addition, we showed that TGF-β1 significantly induced proliferation of PASMC, while pre-inhibition of Smad2/3 phosphorylation with SB431542 or silencing SphK1 using small interfering RNA in advance, or pre-blocking Notch3 pathway with N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT), attenuated TGF-β1-induced PASMC proliferation.

SphK1/S1P mediates TGF-β1-induced proliferation of pulmonary artery smooth muscle cells and its potential mechanisms [10.1177/2045894018816977]


Differential metabolites were enriched into three crucial pathways, including biosynthesis of phenylpropanoids, flavonoid biosynthesis, and flavone and flavonol biosynthesis, which might influence the quality of tea.

Non-targeted Metabolomic Analysis Based on Ultra-High-Performance Liquid Chromatography Quadrupole Time-of-Flight Tandem Mass Spectrometry Reveals the Effects of Grafting on Non-volatile Metabolites in Fresh Tea Leaves ( Camellia sinensis L.). [10.1021/acs.jafc.9b01001]


BackgroundExcessive activation of NLRP3 inflammasome and down-regulation of Sirt1/Smad3 deacetylation pathway play a significant role in the evolution of renal fibrosis.

Shen Shuai IIRecipe attenuates renal injury and fibrosis in chronic kidney disease by regulating NLRP3 inflammasome and Sirt1/Smad3 deacetylation pathway [10.1186/s12906-019-2524-6]


Western blot assays were used to analyze the Akt, MMP2, MMP9 and E-cadherin/N-cadherin/vimentin pathway changes after overexpression of MAGI1.

MAGI1 Inhibits the Proliferation, Migration and Invasion of Glioma Cells [10.2147/OTT.S230236]


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