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Journal of Diabetes Research
Research Hotspot & Journal Scope - Inhibiting


Journal of Diabetes Research - DOI: 10.1155/2019/2981705
Effect of Baoshenfang Formula on Podocyte Injury via Inhibiting the NOX-4/ROS/p38 Pathway in Diabetic Nephropathy

Fang-qiang Cui · Long Tang · Yan-bin Gao · Yue-fen Wang · Yuan Meng · Cun Shen · Zi-long Shen · Zhi-qiang Liu · Wen-jing Zhao · Wei Jing Liu ·

Medicine Chemistry
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Journal of Diabetes Research - DOI: 10.1155/2019/2510105
Nrf2-Heme Oxygenase-1 Attenuates High-Glucose-Induced Epithelial-to-Mesenchymal Transition of Renal Tubule Cells by Inhibiting ROS-Mediated PI3K/Akt/GSK-3β Signaling

Jong Ho Shin · Kyeong Min Kim · Jin Uk Jeong · Jae Min Shin · Ju Hyung Kang · Kitae Bang · Joo-Heon Kim ·

Chemistry Medicine
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Journal of Diabetes Research - DOI: 10.1155/2019/7869318
Dexmedetomidine Attenuates Myocardial Ischemia-Reperfusion Injury in Diabetes Mellitus by Inhibiting Endoplasmic Reticulum Stress

Jinjie Li · Ying Zhao · Nan Zhou · Longyun Li · Kai Li ·

Medicine
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Journal of Diabetes Research - DOI: 10.1155/2019/5487962
TAK-875 Mitigates β-Cell Lipotoxicity-Induced Metaflammation Damage through Inhibiting the TLR4-NF-κB Pathway

Xide Chen · Yuanli Yan · Zhiyan Weng · Chao Chen · Miaoru Lv · Qingwen Lin · Qiuxia Du · Ximei Shen · Liyong Yang ·

Chemistry Medicine
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ConclusionCollectively, this study highlights that upregulated miR-200c-3p inhibits expression of SOX2, thereby inhibiting development of RCC cells via modulating the Wnt/β-catenin signaling pathway activation.

Up-regulation of microRNA-200c-3p inhibits invasion and migration of renal cell carcinoma cells via the SOX2-dependent Wnt/β-catenin signaling pathway [10.1186/s12935-019-0944-5]


Moreover, GSP attenuated ER stress-associated apoptosis by inhibiting GRP78 and Caspase-12.

Grape seed proanthocyanidins attenuate apoptosis in ischemic stroke [10.1007/s13760-019-01111-9]


The effect of the Ang‐2/Tie2 receptor inhibiting peptibody L1‐10 was evaluated in the methionine‐choline deficient (MCD) and streptozotocin‐western diet nonalcoholic fatty liver disease mouse models, and in vitro on endothelial cells and bone marrow–derived macrophages.

Angiopoietin‐2 Promotes Pathological Angiogenesis and Is a Therapeutic Target in Murine Nonalcoholic Fatty Liver Disease [10.1002/hep.30294]


Herbicides inhibiting either aromatic or branched-chain amino acid biosynthesis trigger similar physiological responses in plants, despite their different mechanism of action.

ERF-VII transcription factors induce ethanol fermentation in response to amino acid biosynthesis-inhibiting herbicides [10.1093/jxb/erz355]


In cancer cells, MST1/2 play a role in cancer cell proliferation, differentiation and apoptosis by inhibiting YAP1, yet frequent deregulation of MST1/2 leads to hyper-activation of YAP1 in various cancers.

Abstract 862: Inhibition of Hippo tumor suppressors MST1/2 slows prostate cancer cell proliferation and invasion [10.1158/1538-7445.AM2019-862]


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