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Journal of Clinical Oncology
Research Hotspot & Journal Scope - trial


Journal of Clinical Oncology - DOI: 10.1200/JCO.18.02309
Neoadjuvant Modified FOLFOX6 With or Without Radiation Versus Fluorouracil Plus Radiation for Locally Advanced Rectal Cancer: Final Results of the Chinese FOWARC Trial

Yanhong Deng · Pan Chi · Ping Lan · Lei Wang · Weiqing Chen · Long Cui · Daoda Chen · Jie Cao · Hongbo Wei · Xiang Peng · Zonghai Huang · Guanfu Cai · Ren Zhao · Zhongcheng Huang · Lin Xu · Hongfeng Zhou · Yisheng Wei · Hao Zhang · Jian Zheng · Yan Huang · Zhiyang Zhou · Yue Cai · Liang Kang · Meijin Huang · Xiaojian Wu · Junsheng Peng · Donglin Ren · Jianping Wang ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.502
HER2 heterogeneity as a predictor of response to neoadjuvant T-DM1 plus pertuzumab: Results from a prospective clinical trial.

Otto Metzger Filho · Giuseppe Viale · Lorenzo Trippa · Tianyu Li · Denise A. Yardley · Ingrid A. Mayer · Vandana G. Abramson · Carlos L. Arteaga · Laura Spring · Adrienne G. Waks · Michalina Janiszewska · Eileen Wrabel · Michelle Demeo · Aditya Bardia · Tari A. King · Kornelia Polyak · Eric P. Winer · Ian E. Krop ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.5005
TOPARP-B: A phase II randomized trial of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib for metastatic castration resistant prostate cancers (mCRPC) with DNA damage repair (DDR) alterations

Joaquin Mateo · Nuria Porta · U. McGovern · Tony Elliott · Robert Jones · Isabel Syndikus · Christy Ralph · Suneil Jain · Mohini Varughese · O. Parikh · Simon J. Crabb · Susana Miranda · George Seed · Claudia Bertan · Aude Espinasse · Peter Chatfield · Diletta Bianchini · Emma Hall · Suzanne Carreira · Johann S. de Bono ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.1005
Capivasertib (AZD5363) plus fulvestrant versus placebo plus fulvestrant after relapse or progression on an aromatase inhibitor in metastatic ER-positive breast cancer (FAKTION): A randomized, double-blind, placebo-controlled, phase II trial.

Robert Hugh Jones · Margherita Carucci · Angela C. Casbard · Rachel Butler · Fouad S Alchami · Catherine Jane Bale · Pavel Bezecny · Johnathan Joffe · Sarah Moon · Chris Twelves · Ramachandran Venkitaraman · Simon Waters · Sacha J Howell ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.3501
Prospective pooled analysis of four randomized trials investigating duration of adjuvant (adj) oxaliplatin-based therapy (3 vs 6 months {m}) for patients (pts) with high-risk stage II colorectal cancer (CC).

Timothy Iveson · Alberto Sobrero · Takayuki Yoshino · Ioannis Sougklakos · Fang-Shu Ou · Jeffery P. Meyers · Qian Shi · Mark P Saunders · Roberto Labianca · Takeharu Yamanaka · Ioannis Boukovinas · Niels Henrik Hollander · Valter Torri · Kentaro Yamazaki · Vassilis Georgoulias · Sara Lonardi · Andrea Harkin · Gerardo Rosati · James Paul ·

Medicine
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This is particularly an issue in oncology trials where the standard-of-care is shifting rapidly and several promising experimental treatments are undergoing phase III testing.

Minimizing control group allocation in randomized trials using dynamic borrowing of external control data – An application to second line therapy for non-small cell lung cancer [10.1016/j.conctc.2019.100446]


BACKGROUND The long-term efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated in large-scale double-blind placebo-controlled trials.

Prospective Open-Label Study of 48-Week Subcutaneous Administration of Mepolizumab in Japanese Patients With Severe Eosinophilic Asthma. [10.18176/jiaci.0285]


The second Stroke Recovery and Rehabilitation Roundtable “metrics” task force developed consensus around the recognized need to add kinematic and kinetic movement quantification to its core recommendations for standardized measurements of sensorimotor recovery in stroke trials.

Standardized Measurement of Quality of Upper Limb Movement After Stroke: Consensus-Based Core Recommendations From the Second Stroke Recovery and Rehabilitation Roundtable [10.1177/1545968319886477]


The resin also removed MB and Hg(II) simultaneously from industrial wastewater with remarkable efficacy.

Fast removal of methylene blue and Hg(II) from aqueous solution using a novel super-adsorbent containing residues of glycine and maleic acid. [10.1016/j.jhazmat.2019.02.082]


The FOURIER trial was set up to study the clinical outcomes of evolocumab in patients with hypercholesterolemia and a history of cardiovascular disease that use statins.

What the diabetes data in the FOURIER trial fail to show [10.1111/dom.13576]


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