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Journal of Clinical Oncology
Research Hotspot & Journal Scope - therapy


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.3501
Prospective pooled analysis of four randomized trials investigating duration of adjuvant (adj) oxaliplatin-based therapy (3 vs 6 months {m}) for patients (pts) with high-risk stage II colorectal cancer (CC).

Timothy Iveson · Alberto Sobrero · Takayuki Yoshino · Ioannis Sougklakos · Fang-Shu Ou · Jeffery P. Meyers · Qian Shi · Mark P Saunders · Roberto Labianca · Takeharu Yamanaka · Ioannis Boukovinas · Niels Henrik Hollander · Valter Torri · Kentaro Yamazaki · Vassilis Georgoulias · Sara Lonardi · Andrea Harkin · Gerardo Rosati · James Paul ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.19.01507
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer

Carryn M Anderson · Christopher M Lee · Deborah P Saunders · Amarinthia Curtis · Neal Dunlap · Chaitali Nangia · Arielle S Lee · Sharon M Gordon · Philip Kovoor · Roberto Arevalo-Araujo · Voichita Bar-Ad · Abhinand Peddada · Kyle Colvett · Douglas Miller · Anshu K Jain · James Wheeler · Dukagjin Blakaj · Marcelo Bonomi · Sanjiv S Agarwala · Madhur Garg · Francis Worden · Jon Holmlund · Jeffrey M Brill · Matt Downs · Stephen T Sonis · Sanford Katz · John M Buatti ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.95
Anlotinib in chemotherapy-refractory metastatic esophageal squamous cell carcinoma (ESCC): A randomized, double-blind, multicenter phase II trial.

Jing Huang · Juxiang Xiao · Wentao Fang · Ping Lu · Qingxia Fan · Yongqian Shu · Ji Feng Feng · Shu Zhang · Yi Ba · Ying Liu · Chunmei Bai · Yuxian Bai · Yong Tang · Yan Song · Jie He ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.637
Randomized study evaluating trifluridine/tipiracil (TAS-102) versus + trifluridine/tipiracil + bevacizumab as last-line therapy in patients with chemorefractory unresectable metastatic colorectal cancer (mCRC).

Per Pfeiffer · Mette Karen Yilmaz · Søren Møller · Line Maltha · Merete Krogh · Daniela Zitnjak · Caroline Lemb Szameitat · Finn Hejlesen · Karina Gravgaard Thomsen · Camilla Qvortrup ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.7_SUPPL.551
Alterations in DNA damage repair (DDR) genes and outcomes to systemic therapy in 225 immune-oncology (IO) versus tyrosine kinase inhibitor (TKI) treated metastatic clear cell renal cell carcinoma (mccRCC) patients (pts).

Yasser Ged · Joshua Chaim · Andrea Knezevic · Maria I. Carlo · Ashley Foster · Darren R. Feldman · Min Yuen Teo · Nadeem Riaz · Chung-Han Lee · Sujata Patil · Timothy A. Chan · A. Ari Hakimi · Robert J. Motzer · Martin H. Voss ·

Medicine
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Altogether, SIRT1 and/or miR-34a levels may serve as predictors of response to oncolytic-virus therapy.

SIRT1 Modulates the Sensitivity of Prostate Cancer Cells to Vesicular Stomatitis Virus Oncolysis [10.1128/JVI.00626-19]


Since the efficacy of temozolomide therapy is known to depend on the methylation status of the O6-methylguanine-DNA methyltransferase gene (MGMT) promoter, we also analyzed whether the effect of Temodex was influenced by the methylation status of MGMT.

Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival in glioma patients, irrespectively of the methylation status of MGMT. [10.4149/neo_2018_180613N393]


Post‐transplant lymphoproliferative disorder (PTLD) has been reported in pigs receiving intensive immunomodulatory therapy, particularly if this includes whole body irradiation, in an effort to induce mixed hematopoietic chimerism and immunological tolerance.

Will donor‐derived neoplasia be problematic after clinical pig organ or cell xenotransplantation? [10.1111/xen.12469]


Conclusion: Intralesional MMR vaccine immunotherapy appears promising, effective, and safe treatment for common warts in children with the advantage of single-lesion infiltration, and resolution without scarring or pigmentary changes commonly seen with destructive therapies.

Evaluation of efficacy and safety of intralesional Measles-Mumps-Rubella virus vaccine for the treatment of common warts in children and adolescents [10.4103/ijpd.IJPD_106_18]


Epicutaneous immunotherapy (EPIT) reduces features of eosinophilic gastrointestinal disease in mice and pigs.

Efficacy of Epicutaneous Immunotherapy in Children with Milk-Induced Eosinophilic Esophagitis. [10.1016/j.cgh.2019.05.014]


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