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Journal of Clinical Oncology
Research Hotspot & Journal Scope - repair


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.5005
TOPARP-B: A phase II randomized trial of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib for metastatic castration resistant prostate cancers (mCRPC) with DNA damage repair (DDR) alterations

Joaquin Mateo · Nuria Porta · U. McGovern · Tony Elliott · Robert Jones · Isabel Syndikus · Christy Ralph · Suneil Jain · Mohini Varughese · O. Parikh · Simon J. Crabb · Susana Miranda · George Seed · Claudia Bertan · Aude Espinasse · Peter Chatfield · Diletta Bianchini · Emma Hall · Suzanne Carreira · Johann S. de Bono ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.191
Outcomes in pancreatic adenocarcinoma (PDA) patients (pts) with genetic alterations in DNA damage repair (DDR) pathways: Results from the Know Your Tumor (KYT) program.

Michael J. Pishvaian · Edik M. Blais · Jonathan R. Brody · Davendra Sohal · Andrew Eugene Hendifar · Vincent Chung · Sameh Mikhail · Lola Rahib · Emily E. Lyons · Lisa Tibbetts · Subha Madhavan · Lynn M. Matrisian · Emanuel F. Petricoin ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.7_SUPPL.551
Alterations in DNA damage repair (DDR) genes and outcomes to systemic therapy in 225 immune-oncology (IO) versus tyrosine kinase inhibitor (TKI) treated metastatic clear cell renal cell carcinoma (mccRCC) patients (pts).

Yasser Ged · Joshua Chaim · Andrea Knezevic · Maria I. Carlo · Ashley Foster · Darren R. Feldman · Min Yuen Teo · Nadeem Riaz · Chung-Han Lee · Sujata Patil · Timothy A. Chan · A. Ari Hakimi · Robert J. Motzer · Martin H. Voss ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.60
Association of DNA damage response and repair genes (DDR) mutations and microsatellite instability (MSI), PD-L1 expression, tumor mutational burden (TMB) in gastroesophageal cancers.

Michael Cerniglia · Joanne Xiu · Axel F Grothey · Michael J. Pishvaian · Jimmy J. Hwang · John Marshall · Ari M. Vanderwalde · Anthony F. Shields · Heinz-Josef Lenz · Mohamed E. Salem · Philip A. Philip · Richard M. Goldberg · W. Michael Korn · Sunnie S. Kim ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.E16079
Characterization of tumor mutational burden (TMB), PD-L1, and DNA repair genes to assess correlation with immune checkpoint inhibitors (ICIs) response in metastatic renal cell carcinoma (mRCC).

Matthew Labriola · Jason Zhu · Rajan T. Gupta · Shannon McCall · Jennifer Jackson · James R. White · Elizabeth Weingartner · Eric Kong · Peter Simone · Eniko Papp · Kelly Gerding · John K. Simmons · Daniel J. George · Tian Zhang ·

Medicine
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In this paper, a novel definition of locality is proposed to keep track of the precise number of nodes required for a local repair when the repair sets do not yield MDS codes.

Alphabet-Dependent Bounds for Linear Locally Repairable Codes Based on Residual Codes [10.1109/TIT.2019.2911595]


Then, based on the injection of the low-viscosity epoxy resin (LVER), the repair procedures for the mud pumping are proposed.

Behavior and Control of the Ballastless Track-Subgrade Vibration Induced by High-Speed Trains Moving on the Subgrade Bed with Mud Pumping [10.1155/2019/9838952]


To improve the resistance capacity of repaired composite structures, effects of fiber orientation on perforation mechanisms of bonding- and scarf-patch repaired panel under impact loading are predicted.

Numerical prediction for effects of fiber orientation on perforation resistance behaviors of patch-repaired composite panel subjected to projectile impact [10.1016/J.TWS.2019.106325]


In-process, quantitative characterization and monitoring of material state is anticipated to be potentially transformational in advancing adoption of metal AM parts, including offering the potential for early part rejection, part condition guided process control or even potentially in-process repair.

NDE in-process for metal parts fabricated using powder based additive manufacturing [10.1117/12.2520611]


These data have important implications, namely (a) cells from the PDGFRα‐expressing progenitor lineage (which are presumably oligodendrocyte progenitor cells, OPCs) can differentiate into remyelinating PNS‐like Schwann cells after traumatic SCI, (b) this process is controlled by ErbB tyrosine kinase signaling, and (c) this endogenous repair mechanism has significant consequences for functional recovery after SCI.

ErbB receptor signaling directly controls oligodendrocyte progenitor cell transformation and spontaneous remyelination after spinal cord injury [10.1002/glia.23586]


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