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Journal of Clinical Oncology
Research Hotspot & Journal Scope - receptor


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.9000
RELAY: A multinational, double-blind, randomized Phase 3 study of erlotinib (ERL) in combination with ramucirumab (RAM) or placebo (PL) in previously untreated patients with epidermal growth factor receptor mutation-positive (EGFRm) metastatic non-small cell lung cancer (NSCLC).

Kazuhiko Nakagawa · Edward B. Garon · Takashi Seto · Makoto Nishio · Santiago Ponce Aix · Chao-Hua Chiu · Keunchil Park · Silvia Novello · Ernest Nadal · Fumio Imamura · Kiyotaka Yoh · Jin-Yuan Shih · Kwok Hung Au · Denis Moro-Sibilot · Sotaro Enatsu · Annamaria Zimmermann · Bente Frimodt-Moller · Carla M. Visseren Grul · Martin Reck ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.E12533
Abemaciclib with or without fulvestrant for the treatment of hormone receptor-positive and HER2-negative metastatic breast cancer with disease progression following prior treatment with palbociclib.

Keerthi Tamragouri · Melody A. Cobleigh · Ruta D. Rao ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.6602
Patient-reported outcomes from two global multicenter clinical trials of children and adults with tropomyosin receptor kinase (TRK) fusion cancer receiving larotrectinib.

Shivaani Kummar · Leo Mascarenhas · Birgit Geoerger · Brian Turpin · Michael C. Cox · Sandie Yu · Shivani Nanda · Florian Hiemeyer · Karen N. Keating · Costel Chirila · Ari Gnanasakthy · Eric Davenport · David S. Hong · Alexander Drilon ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.1047
A phase II study of pembrolizumab in combination with palliative radiotherapy (RT) for hormone receptor-positive (HR+) metastatic breast cancer (MBC).

Romualdo Barroso-Sousa · Ian E. Krop · Lorenzo Trippa · Zhenying Tan-Wasielewski · Tianyu Li · Wafa Osmani · Chelsea Andrews · Deborah A. Dillon · Edward T. Richardson · Eric P. Winer · Elizabeth Ann Mittendorf · Jonathan D. Schoenfeld · Sara M. Tolaney ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.11510
Validating the Cancer and Aging Research Group (CARG) toxicity prediction tool in older men receiving chemotherapy for metastatic castration-resistant prostate cancer (mCRPC) and extending it to androgen receptor targeted agents.

Shabbir M.H. Alibhai · Henriette Breunis · Richard Gregg · Aaron Richard Hansen · Padraig Warde · Narhari Timilshina · George Tomlinson · Anthony M. Joshua · Neil E. Fleshner · Urban Emmenegger ·

Medicine
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We apply this new strategy to a panel of wild-type and mutant mice with a liver-specific gene deletion of Liver receptor homolog 1 (Lrh-1hep−/−), with both lines containing control individuals as well as individuals with liver cancer induced by diethylnitrosamine (DEN).

A new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model [10.1038/s41598-019-43091-z]


c-Met activation promotes epithelial-to-mesenchymal transition (EMT) in renal cancer cells through the upregulation of the chemokine receptor CXCR7 [abstract].

Abstract 1039: c-Met activation promotes epithelial-to-mesenchymal transition (EMT) in renal cancer cells through the upregulation of the chemokine receptor CXCR7 [10.1158/1538-7445.AM2019-1039]


S1P3 receptor was induced along with sphingosine kinase 1 by stimulation of lipopolysaccharide (LPS).

Pro-Inflammatory Role of S1P3 in Macrophages [10.4062/biomolther.2018.215]


Blocking alpha-adrenergic receptors reversed the effect of epinephrine on glucose + non-esterified fatty acids (NEFA)-induced beta-cell proliferation, whereas activation of beta-adrenergic receptors was without effect.

The autonomic nervous system regulates pancreatic beta-cell proliferation in adult male rats. [10.1152/ajpendo.00385.2018]


dbd-specific overexpression of the guidance receptors Unc-5 or Robo-2 results in lateralization of the dbd axon, which forms anatomical and functional monosynaptic connections with the A08a lateral dendrite.

Regulation of subcellular dendritic synapse specificity by axon guidance cues [10.7554/eLife.43478]


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