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Journal of Clinical Oncology
Research Hotspot & Journal Scope - radiotherapy


Journal of Clinical Oncology - DOI: 10.1200/JCO.19.01507
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer

Carryn M Anderson · Christopher M Lee · Deborah P Saunders · Amarinthia Curtis · Neal Dunlap · Chaitali Nangia · Arielle S Lee · Sharon M Gordon · Philip Kovoor · Roberto Arevalo-Araujo · Voichita Bar-Ad · Abhinand Peddada · Kyle Colvett · Douglas Miller · Anshu K Jain · James Wheeler · Dukagjin Blakaj · Marcelo Bonomi · Sanjiv S Agarwala · Madhur Garg · Francis Worden · Jon Holmlund · Jeffrey M Brill · Matt Downs · Stephen T Sonis · Sanford Katz · John M Buatti ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.8502
Initial reporting of NRG-LU001 (NCT02186847), randomized phase II trial of concurrent chemoradiotherapy (CRT) +/- metformin in locally advanced Non-Small Cell Lung Cancer (NSCLC).

Theodoros Tsakiridis · Chen Hu · Heath D. Skinner · Rafael Santana-Davila · Bo Lu · Jeremy J. Erasmus · A Doemer · Gregory M.M. Videtic · J. Coster · Xuezhong Yang · Richard J. Lee · Maria Werner-Wasik · Philip E. Schaner · Steven Eric McCormack · Benjamin T. Esparaz · Ronald C. McGarry · Jose G. Bazan · Timothy Struve · Jeffrey D. Bradley ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.1047
A phase II study of pembrolizumab in combination with palliative radiotherapy (RT) for hormone receptor-positive (HR+) metastatic breast cancer (MBC).

Romualdo Barroso-Sousa · Ian E. Krop · Lorenzo Trippa · Zhenying Tan-Wasielewski · Tianyu Li · Wafa Osmani · Chelsea Andrews · Deborah A. Dillon · Edward T. Richardson · Eric P. Winer · Elizabeth Ann Mittendorf · Jonathan D. Schoenfeld · Sara M. Tolaney ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.E14104
Evaluation of radiotherapeutic and immune-modulatory response to whole brain radiotherapy or stereotactic radiosurgery in patients with brain metastases from malignant melanoma treated with or without ipilimumab (ELEKTRA).

Jessica C. Hassel · Heiko Smetak · Martin Salzmann · Matthias F. Haefner · Denise Bernhardt · Ingrid Hülsmeyer · Alexander Enk · Juergen Debus · Philipp Beckhove ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.8_SUPPL.70
Regulatory T cells mediate resistance to radiotherapy in head and neck squamous cell carcinoma.

Ayman Oweida · Laurel Darragh · Shilpa Bhatia · David Raben · Lynn E. Heasley · Raphael A. Nemenoff · Eric T. Clambey · Sana D. Karam ·

Medicine
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Age, year of surgery, cancer risk group, hospital volume, post-operative radiotherapy RT/hormonal treatment ADT, resection margins, nerve sparing and lymphadenectomy were included as possible predictive factors.

MP54-03 PREDICTIVE FACTORS OF POSTOPERATIVE QUALITY OF LIFE, ERECTILE FUNCTION AND CONTINENCE AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY: A MULTICENTRE STUDY [10.1097/01.JU.0000556692.21405.ad]


Purpose: In the last years, some studies investigated dosimetric benefits of a free flattening filter for the photon mode in the radiotherapy field.

Enhancement of the Dose on 12 MV Linac with Free Flattening Filter Mode. [10.31661/JBPE.V0I0.924]


: Purpose: This in-vitro study aimed to assess in 120 [40 community-acquired (CA-MRSA) & 80 hospital-acquired (HA-MRSA)] isolates from cancer patients whether the transmissible staphylococcal cassette chromosome mec (SCCmec) typing, and the Panton–Valentine leukocidin (PVL) virulence genes detection could be employed as tools for molecular diagnostic purposes to distinguish both methicillin-resistant Staphylococcus aureus (MRSA) categories in radiotherapy treated cancer patients.

Effects of gamma-irradiation on antibiotic resistance and diagnostic molecular markers of methicillin-resistant Staphylococcus aureus in Egyptian cancer patients [10.1080/09553002.2019.1664785]


Treatment of our patient with the combination of an anti-PD-1 antibody (Nivolumab) and an anti-CTLA4 antibody (Ipilimumab) showed a stabilization of life-threatening retrocardiac tumoral masses that had previous significantly progressed despite radiotherapy, while one bone lesion in the right os ilium was growing and needed treatment with concomitant radiotherapy.

NGS-analysis to the rescue: dual checkpoint inhibition in metastatic osteosarcoma - a case report and review of the literature. [10.1080/17843286.2019.1683129]


This novel deep-learning-based approach with the GAN strategy can automatically and accurately segment multiple OARs in thorax CT images, which could be a useful tool to improve the efficiency of the lung radiotherapy treatment planning.

Automatic multi-organ segmentation in thorax CT images using U-Net-GAN [10.1117/12.2512552]


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