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Journal of Clinical Oncology
Research Hotspot & Journal Scope - pancreatic


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.191
Outcomes in pancreatic adenocarcinoma (PDA) patients (pts) with genetic alterations in DNA damage repair (DDR) pathways: Results from the Know Your Tumor (KYT) program.

Michael J. Pishvaian · Edik M. Blais · Jonathan R. Brody · Davendra Sohal · Andrew Eugene Hendifar · Vincent Chung · Sameh Mikhail · Lola Rahib · Emily E. Lyons · Lisa Tibbetts · Subha Madhavan · Lynn M. Matrisian · Emanuel F. Petricoin ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.358
Real world usage of gemcitabine and nabpaclitaxel in older adults with metastatic pancreatic cancer: A single institution experience.

Arthur Winer · Elizabeth Handorf · Lavanya Nagappan · Aryeh Blumenreich · Farhana Chowdhury · Namrata Vijayvergia · Efrat Dotan ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.1506
Ten-fold increase in genetic testing in pancreatic and metastatic prostate cancer with implementation of point of care (POC) testing.

Heather Symecko · Rebecca Mueller · Kelsey Spielman · Melissa Batson · Stacy Pundock · Jada G. Hamilton · Mark E. Robson · Susan M. Domchek ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.407
Dynamical changes of treatment patterns and outcomes of unresectable pancreatic cancer patients in real-life practice.

Kazuki Nagai · Takeshi Terashima · Tatsuya Yamashita · Hidenori Kido · Kotaro Hayashi · Hajime Sunagozaka · Ryotaro Nakai · Hideki Mizuno · Hikaru Hayakawa · Yoshimoto Nomura · Yoshiko Takata · Noriaki Orita · Hisashi Takabatake · Masataka Kanno · Masaki Nishitani · Hitoshi Omura · Haruhiko Shugo · Naoki Ooishi · Eishiro Mizukoshi · Shuichi Kaneko ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.344
Multicenter retrospective analysis for efficacy and safety of liposomal irinotecan (nal-IRI) plus 5-FU/leucovorin (5-FU/LV) after progression on gemcitabine-based therapy in Korean patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC): A study by Korean Cancer Study Group (KCSG).

Changhoon Yoo · Hyeon-Su Im · Kyu-pyo Kim · Do-Youn Oh · Kyung-Hun Lee · Hong Jae Chon · Joo Hoon Kim · Myoung Joo Kang · Il-Hwan Kim · Guk Jin Lee · Sung Yong Oh · Younak Choi · Hye Jin Choi · Seung Tae Kim · Joon Oh Park · Baek-Yeol Ryoo ·

Medicine
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Pancreatic beta cells produce insulin on intricate cellular assembly line, but the extent of the gut microbiota involvement was not clear.

Microbiota guides insulin trafficking in beta cells [10.1038/s41422-019-0200-5]


Patients can develop pancreatic fluid collections including acute pancreatic fluid collections, pancreatic pseudocysts, acute necrotic collections, and walled-off necrosis.

Management of severe acute pancreatitis [10.1136/bmj.l6227]


GPC1 is a cell surface membrane protein and has been reported as a poor prognostic factor in pancreatic cancer.

Abstract 4833: Antibody-drug conjugate targeting glypican-1 shows tumor growth inhibition in cholangiocarcinoma [10.1158/1538-7445.AM2019-4833]


CONCLUSIONS In conclusion, LE as a natural herbal extract was efficiently able to induce the differentiation of P19 EC cells into the clusters similar to pancreatic islets with the molecular, cellular and functional characteristics of mature β cells.

In vitro differentiation induction of embryonal carcinoma stem cells into insulin-producing cells by Cichorium intybus L. leaf extract. [10.1016/j.jep.2019.112214]


The goals of this study were to evaluate the effect of the combination of lingaliptin + metformin + lifestyle on glucose tolerance, pancreatic β-cell function and T2D incidence in patients with prediabetes.

The combination of Linagliptin, Metformin and Lifestyle Modification to prevent Type 2 Diabetes (PRELLIM). A randomized clinical trial. [10.1016/j.metabol.2019.154054]


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