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Journal of Clinical Oncology
Research Hotspot & Journal Scope - immune


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.9017
Spatial and temporal heterogeneity of PD-L1 and its impact on benefit from immune checkpoint blockade in non-small cell lung cancer (NSCLC).

Lingzhi Hong · Seyedeh Dibaj · Marcelo Vailati Negrao · Alexandre Reuben · Emily Roarty · Waree Rinsurongkawong · Jeffrey A. Lewis · Don Lynn Gibbons · Boris Sepesi · Vassiliki A Papadimitrakopoulou · Bonnie S. Glisson · George R. Blumenschein · Phillip Andrew Futreal · Ignacio Ivan Wistuba · Jack A. Roth · Stephen G. Swisher · John Victor Heymach · George R. Simon · Jiun-Kae Jack Lee · Jianjun Zhang ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.4116
Immune checkpoint inhibitors (ICIs) in gastrointestinal (GI) cancer: Immune-related adverse events (IRAEs) and efficacy.

Satya Das · Kristen Keon Ciombor · Sigurdis Haraldsdottir · Yoanna S Pumpalova · Ibrahim Halil Sahin · Yu Shyr · Shih-Kai Chu · Emily Pei-Ying Lin · Chih-Yuan Hsu · Laura W. Goff · Dana Backlund Cardin · Mehmet Asim Bilen · Jordan Berlin · Christina Wu ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.7_SUPPL.551
Alterations in DNA damage repair (DDR) genes and outcomes to systemic therapy in 225 immune-oncology (IO) versus tyrosine kinase inhibitor (TKI) treated metastatic clear cell renal cell carcinoma (mccRCC) patients (pts).

Yasser Ged · Joshua Chaim · Andrea Knezevic · Maria I. Carlo · Ashley Foster · Darren R. Feldman · Min Yuen Teo · Nadeem Riaz · Chung-Han Lee · Sujata Patil · Timothy A. Chan · A. Ari Hakimi · Robert J. Motzer · Martin H. Voss ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.2587
Real-world outcomes of underrepresented patient populations treated with immune checkpoint inhibitors (ICIs): African American descent, poor ECOG performance status, and chronic viral infections.

Neil J. Shah · Matthew Blackburn · Michael R. Cook · Anas Belouali · Michael Serzan · William J Kelly · Athanasios Bikas · Chul Kim · Subha Madhavan · Stephen V. Liu · Michael B. Atkins ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.E16079
Characterization of tumor mutational burden (TMB), PD-L1, and DNA repair genes to assess correlation with immune checkpoint inhibitors (ICIs) response in metastatic renal cell carcinoma (mRCC).

Matthew Labriola · Jason Zhu · Rajan T. Gupta · Shannon McCall · Jennifer Jackson · James R. White · Elizabeth Weingartner · Eric Kong · Peter Simone · Eniko Papp · Kelly Gerding · John K. Simmons · Daniel J. George · Tian Zhang ·

Medicine
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Here we used multiparameter flow cytometry to examine the immune profiles of 39 tumor biopsies obtained from 31 patients with stage III-IV metastatic melanoma prior to (baseline, n = 21) or during (n = 18) single-agent anti-PD1 immunotherapy; twelve patients developed resistance to treatment.

Abstract A154: Flow cytometric analysis of immune responses in the melanoma tissue biopsies before or during anti-PD1 immunotherapy [10.1158/2326-6074.CRICIMTEATIAACR18-A154]


Occasionally, thrombocytopenia can be a life threatening condition in pregnancy when is due to pregnancy-related hypertension spectrum (preeclampsia, eclampsia), HELLP syndrome, acute fatty liver of pregnancy, immune thrombocytopenic purpura (ITP), hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), sepsis, malignancy or disseminated intravascular coagulapathy (DIC).

Pseudothrombocytopenia in Obstetric Patients: Case Reports [10.5336/jcog.2019-71754]


Compelling evidence has shown that blocking VEGF via monoclonal antibodies may be beneficial in that it not only inhibits tumor angiogenesis but also reduces immune suppression and promotes T cell infiltration into tumors.

Utilizing VEGF165b mutant as an effective immunization adjunct to augment antitumor immune response. [10.1016/j.vaccine.2019.02.055]


Gene mutations are found in some cases, but its immune pathogenesis is largely unknown.

Neutrophil exosomes enhance the skin autoinflammation in generalized pustular psoriasis via activating keratinocytes [10.1096/fj.201802090RR]


These data highlight a need to understand the mechanisms of immune dysfunction and to define predictors of clinical risk among DLBCL survivors.

INTERNATIONAL PROGNOSTIC SCORE FOR EARLY STAGE CHRONIC LYMPHOCYTIC LEUKEMIA (IPS‐A) [10.1002/hon.51_2629]


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