Journal of Clinical Oncology

Research Hotspot & Journal Scope - immune

Here we used multiparameter flow cytometry to examine the immune profiles of 39 tumor biopsies obtained from 31 patients with stage III-IV metastatic melanoma prior to (baseline, n = 21) or during (n = 18) single-agent anti-PD1 immunotherapy; twelve patients developed resistance to treatment.

Occasionally, thrombocytopenia can be a life threatening condition in pregnancy when is due to pregnancy-related hypertension spectrum (preeclampsia, eclampsia), HELLP syndrome, acute fatty liver of pregnancy, immune thrombocytopenic purpura (ITP), hemolytic uremic syndrome (HUS), thrombotic thrombocytopenic purpura (TTP), sepsis, malignancy or disseminated intravascular coagulapathy (DIC).

Compelling evidence has shown that blocking VEGF via monoclonal antibodies may be beneficial in that it not only inhibits tumor angiogenesis but also reduces immune suppression and promotes T cell infiltration into tumors.

Gene mutations are found in some cases, but its immune pathogenesis is largely unknown.

These data highlight a need to understand the mechanisms of immune dysfunction and to define predictors of clinical risk among DLBCL survivors.