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Journal of Clinical Oncology
Research Hotspot & Journal Scope - immune


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.9017
Spatial and temporal heterogeneity of PD-L1 and its impact on benefit from immune checkpoint blockade in non-small cell lung cancer (NSCLC).

Lingzhi Hong · Seyedeh Dibaj · Marcelo Vailati Negrao · Alexandre Reuben · Emily Roarty · Waree Rinsurongkawong · Jeffrey A. Lewis · Don Lynn Gibbons · Boris Sepesi · Vassiliki A Papadimitrakopoulou · Bonnie S. Glisson · George R. Blumenschein · Phillip Andrew Futreal · Ignacio Ivan Wistuba · Jack A. Roth · Stephen G. Swisher · John Victor Heymach · George R. Simon · Jiun-Kae Jack Lee · Jianjun Zhang ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.4116
Immune checkpoint inhibitors (ICIs) in gastrointestinal (GI) cancer: Immune-related adverse events (IRAEs) and efficacy.

Satya Das · Kristen Keon Ciombor · Sigurdis Haraldsdottir · Yoanna S Pumpalova · Ibrahim Halil Sahin · Yu Shyr · Shih-Kai Chu · Emily Pei-Ying Lin · Chih-Yuan Hsu · Laura W. Goff · Dana Backlund Cardin · Mehmet Asim Bilen · Jordan Berlin · Christina Wu ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.7_SUPPL.551
Alterations in DNA damage repair (DDR) genes and outcomes to systemic therapy in 225 immune-oncology (IO) versus tyrosine kinase inhibitor (TKI) treated metastatic clear cell renal cell carcinoma (mccRCC) patients (pts).

Yasser Ged · Joshua Chaim · Andrea Knezevic · Maria I. Carlo · Ashley Foster · Darren R. Feldman · Min Yuen Teo · Nadeem Riaz · Chung-Han Lee · Sujata Patil · Timothy A. Chan · A. Ari Hakimi · Robert J. Motzer · Martin H. Voss ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.2587
Real-world outcomes of underrepresented patient populations treated with immune checkpoint inhibitors (ICIs): African American descent, poor ECOG performance status, and chronic viral infections.

Neil J. Shah · Matthew Blackburn · Michael R. Cook · Anas Belouali · Michael Serzan · William J Kelly · Athanasios Bikas · Chul Kim · Subha Madhavan · Stephen V. Liu · Michael B. Atkins ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.E16079
Characterization of tumor mutational burden (TMB), PD-L1, and DNA repair genes to assess correlation with immune checkpoint inhibitors (ICIs) response in metastatic renal cell carcinoma (mRCC).

Matthew Labriola · Jason Zhu · Rajan T. Gupta · Shannon McCall · Jennifer Jackson · James R. White · Elizabeth Weingartner · Eric Kong · Peter Simone · Eniko Papp · Kelly Gerding · John K. Simmons · Daniel J. George · Tian Zhang ·

Medicine
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Samples from 30 patients were available for immune analysis.

Multicenter phase I trial of a DNA vaccine encoding the androgen receptor ligand binding domain (pTVG-AR, MVI-118) in patients with metastatic prostate cancer [10.1093/annonc/mdz248.032]


Large studies have shown childhood-onset autoimmune diabetes is 4 times more common in DS than in the general population, and has an intermediate HLA association (6).

Trisomy 21 is a cause of permanent neonatal diabetes that is autoimmune but not HLA associated [10.1530/ey.16.2.6]


The patient's autoantibody profile was consistent with a drug-induced autoimmune process and renal histology revealed focal necrotizing crescentic GN.

Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis. [10.4103/1319-2442.252915]


A possible explanation is that corticosteroids, even if taken for a short time, led to a transient lowering of immune function and contributed to negative outcome.

Concomitant cerebral aspergillosis and mucormycosis in an immunocompetent woman treated with corticosteroids [10.1007/s13365-019-00804-4]


The iron-chelating peptide of Grifola frondosa still maintained its immune enhancing activity after in vitro gastrointestinal digestion.

A peptide-Fe(II) complex from Grifola frondosa protein hydrolysates and its immunomodulatory activity [10.1016/j.fbio.2019.100459]


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