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Journal of Clinical Oncology
Research Hotspot & Journal Scope - cancers


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.5005
TOPARP-B: A phase II randomized trial of the poly(ADP)-ribose polymerase (PARP) inhibitor olaparib for metastatic castration resistant prostate cancers (mCRPC) with DNA damage repair (DDR) alterations

Joaquin Mateo · Nuria Porta · U. McGovern · Tony Elliott · Robert Jones · Isabel Syndikus · Christy Ralph · Suneil Jain · Mohini Varughese · O. Parikh · Simon J. Crabb · Susana Miranda · George Seed · Claudia Bertan · Aude Espinasse · Peter Chatfield · Diletta Bianchini · Emma Hall · Suzanne Carreira · Johann S. de Bono ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.6018
Activity and tolerability of BLU-667, a highly potent and selective RET inhibitor, in patients with advanced RET-altered thyroid cancers.

Matthew H. Taylor · Justin F. Gainor · Mimi I-Nan Hu · Viola W. Zhu · Gilberto Lopes · Sophie Leboulleux · Marcia S. Brose · Martin Schuler · Daniel W. Bowles · Dong-Wan Kim · Christina S. Baik · Elena Garralda · Chia-Chi Lin · Douglas Adkins · Debashis Sarker · Giuseppe Curigliano · Hui Zhang · Corinne Clifford · Christopher D. Turner · Vivek Subbiah ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.TPS5091
IMPACT: Immunotherapy in patients with metastatic cancers and CDK12 mutations.

Melissa Andrea Reimers · Wassim Abida · Jonathan Chou · Daniel J. George · Elisabeth I. Heath · Rana R. McKay · Russell Pachynski · Jingsong Zhang · Jae Eun Choi · Felix Y. Feng · Gina M. Neshewat · Marcin Cieslik · Stephanie Daignault-Newton · Eric J. Small · Arul M. Chinnaiyan · Ajjai Alva ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.60
Association of DNA damage response and repair genes (DDR) mutations and microsatellite instability (MSI), PD-L1 expression, tumor mutational burden (TMB) in gastroesophageal cancers.

Michael Cerniglia · Joanne Xiu · Axel F Grothey · Michael J. Pishvaian · Jimmy J. Hwang · John Marshall · Ari M. Vanderwalde · Anthony F. Shields · Heinz-Josef Lenz · Mohamed E. Salem · Philip A. Philip · Richard M. Goldberg · W. Michael Korn · Sunnie S. Kim ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.TPS179
bTMB-High Basket trial: A multicenter phase II trial of nivolumab monotherapy in patients with advanced gastrointestinal cancers with high blood tumor mutational burden (bTMB).

Yoshiaki Nakamura · Yoshito Komatsu · Ken Kato · Eiji Shinozaki · Hideaki Bando · Takeshi Kato · Tomohiro Nishina · Taito Esaki · Shogo Nomura · Gakuto Ogawa · Ayako Sugama · Miki Fukutani · Akihiro Sato · Justin I. Odegaard · Takeshi Kuwata · Kouji Matsushima · Tetsuya Nakatsura · Hiromichi Nakajima · Takayuki Yoshino ·

Medicine
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Hepatic and pancreatobiliary cancers often present at advanced stages, and currently, there are very few approved therapeutic options.

Predictive Biomarkers and Targeted Therapies in Hepatic, Pancreatic, and Biliary Cancers [10.1007/978-3-319-95228-4_40]


Germline TP53 pathogenic variants are rare but associated with a high risk of cancer; they are often identified in the context of clinically diagnosed Li–Fraumeni syndrome predisposing to a range of young onset cancers including sarcomas and breast cancer.

Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study) [10.1002/cjp2.133]


Lysine (K)‐specific demethylase 2B (KDM2B) has been testified to be an oncogene in diverse cancers, which joins in mediating the carcinogenesis of cancers.

CBP‐triggered KDM2B acetylation accelerates the carcinogenesis of colon cancer [10.1002/jcp.29196]


Colorectal cancer (CRC) is one of the most common digestive cancers leading to deaths worldwide.

Serum miR-663 expression and the diagnostic value in colorectal cancer [10.1080/21691401.2019.1628036]


5% of all gastrointestinal cancers and approximately 7% of all periampullary cancers.

Staging for Ampullary Carcinoma: Is Less Actually More? [10.1245/s10434-019-07241-x]


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