Journal of Clinical Oncology

Research Hotspot & Journal Scope - adjuvant

Given the low‐quality evidence observed in this scoping review for adjuvant treatments, the implication for practice is that current management guidelines be followed.

L-theanine is an amino acid naturally found in green tea (Camellia sinensis) and some other plant extracts, and recent clinical studies have proposed promising adjuvant effects of L-theanine for the negative impact of anxiety and psychological stress on health.

A total of 184 patients (HER2 33%, TNBC 27%), with a mean follow-up time of 4 years, treated with neoadjuvant systemic therapy (92% anthracycline-taxane based) were analyzed revealing 43 events (38 recurrences, 28 deaths).

CONCLUSION The intranasal influenza vaccine adjuvanted with LTh(αK) is generally safe and could provide systemic and local antibody responses.

▶ Bemerkenswert ist, mit welcher Schnelligkeit sich die Dreifachkombination ohne direkten Vergleich zu dem derzeit gängigen Standard Gemcitabin/Capecitabin als Therapie der ersten Wahl in der adjuvanten Situation durchgesetzt hat.