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Journal of Clinical Oncology
Research Hotspot & Journal Scope - Clinical


Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.502
HER2 heterogeneity as a predictor of response to neoadjuvant T-DM1 plus pertuzumab: Results from a prospective clinical trial.

Otto Metzger Filho · Giuseppe Viale · Lorenzo Trippa · Tianyu Li · Denise A. Yardley · Ingrid A. Mayer · Vandana G. Abramson · Carlos L. Arteaga · Laura Spring · Adrienne G. Waks · Michalina Janiszewska · Eileen Wrabel · Michelle Demeo · Aditya Bardia · Tari A. King · Kornelia Polyak · Eric P. Winer · Ian E. Krop ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.4_SUPPL.487
Immunoscore clinical utility to identify good prognostic colon cancer stage II patients with high-risk clinico-pathological features for whom adjuvant treatment may be avoided.

Jérôme Galon · Fabienne Hermitte · Bernhard Mlecnik · Florence Marliot · Carlo Bifulco · Alessandro Lugli · Iris D. Nagtegaal · Arndt Hartmann · Marc Van den Eynde · Michael H. A. Roehrl · Pamela S. Ohashi · Eva Zavadova · Toshihiko Torigoe · Prabhudas S. Patel · Yili Wang · Yutaka Kawakami · Francesco M. Marincola · Paolo A. Ascierto · Bernard A. Fox · Franck Pagès ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.E15084
Analytical and clinical validation of a novel amplicon-based NGS assay for evaluation of circulating tumor DNA in metastatic colorectal cancer patients.

Beili Wang · Shengchao Wu · Fei Huang · Min-Na Shen · Huiqin Jiang · Yiyi Yu · Qian Yu · Yihui Yang · Ying Zhao · Yiwen Zhou · Baishen Pan · Tianshu Liu · Wei Guo ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.520
Low-fat dietary pattern and long-term breast cancer incidence and mortality: The Women’s Health Initiative randomized clinical trial.

Rowan T. Chlebowski · Aaron K. Aragaki · Garnet L. Anderson · Kathy Pan · Marian L. Neuhouser · JoAnn E. Manson · Cynthia A. Thomson · Yasmin Mossavar-Rahmani · Dorothy S. Lane · Karen C. Johnson · Jean Wactawski-Wende · Snetselaar Linda · Thomas E. Rohan · Juhua Luo · Ana Barac · Ross L. Prentice ·

Medicine
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Journal of Clinical Oncology - DOI: 10.1200/JCO.2019.37.15_SUPPL.6602
Patient-reported outcomes from two global multicenter clinical trials of children and adults with tropomyosin receptor kinase (TRK) fusion cancer receiving larotrectinib.

Shivaani Kummar · Leo Mascarenhas · Birgit Geoerger · Brian Turpin · Michael C. Cox · Sandie Yu · Shivani Nanda · Florian Hiemeyer · Karen N. Keating · Costel Chirila · Ari Gnanasakthy · Eric Davenport · David S. Hong · Alexander Drilon ·

Medicine
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Incidence of CPE increased over the surveillance period to 1·42 cases/100,000 population, however active clinical infections remained steady since 2017 (0·45-0·60/infections/100,000 population, p=0·640), indicating an increase in screening, case ascertainment, and resolution of transmission networks.

Search and Contain: Centralised Prospective Genomic and Epidemiological Surveillance for the Identification and Control of Carbapenemase-Producing Enterobacterales Transmission [10.2139/ssrn.3498431]


There was no significant difference in basic clinical characteristics among the groups.

General anesthesia combined with epidural anesthesia maintaining appropriate anesthesia depth may protect excessive production of inflammatory cytokines and stress hormones in colon cancer patients during and after surgery [10.1097/MD.0000000000016610]


Many compounds are entering early-phase clinical trials.

Drugs in Development for Acute Kidney Injury [10.1007/s40265-019-01119-8]


We are surprised, that a respectable scientific Journal as The European Journal of Clinical Nutrition offers the sugar industry a stage to publish a obviously biased report to undermine effective public health policies and programs [9].

Comments on: “The role of dietary sugars in health: molecular composition or just calories?” [10.1038/s41430-019-0456-3]


Diagnosis was often delayed and required several clinical consultations.

The public health importance of scabies in community domiciliary care settings: an exploratory cross-sectional survey of Health Protection Teams in England [10.1017/S0950268819001274]


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