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Endocrine Pathology
Research Hotspot & Journal Scope - BRAF


Endocrine Pathology - DOI: 10.1007/s12022-019-09585-2
A Systematic Review and Meta-Analysis of the Diagnostic Performance of BRAF V600E Immunohistochemistry in Thyroid Histopathology

Ranjit Singarayer · Ozgur Mete · Laure Perrier · Lehana Thabane · Sylvia L. Asa · Stan Van Uum · Shereen Ezzat · David P. Goldstein · Anna M. Sawka ·

Medicine
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Endocrine Pathology - DOI: 10.1007/s12022-019-09596-z
Testing for BRAF (V600E) Mutation in Thyroid Nodules with Fine-Needle Aspiration (FNA) Read as Suspicious for Malignancy (Bethesda V, Thy4, TIR4): a Systematic Review and Meta-analysis

Pierpaolo Trimboli · Lorenzo Scappaticcio · Giorgio Treglia · Leo Guidobaldi · Massimo Bongiovanni · Luca Giovanella ·

Medicine
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Endocrine Pathology - DOI: 10.1007/s12022-019-09591-4
The Role of BRAF V600E in Reducing AUS/FLUS Diagnosis in Thyroid Fine Needle Aspiration

Lei Yin · Yi Tang · Shanshan Yu · Chenglong Wang · Ming Xiao · Yalan Wang · Shu Jun Liu · Lu Gao · Keli Huang · Ling Jin ·

Medicine
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In zebrafish oocytes, extensive ooplasmic streaming leads to the segregation of ooplasm from yolk granules along the animal-vegetal axis of the oocyte.

Bulk Actin Dynamics Drive Phase Segregation in Zebrafish Oocytes [10.1016/j.cell.2019.04.030]


In contrast to metastatic melanoma, BRAF inhibition alone or in combination with mitogen-activated protein kinase kinase (MEK) inhibitors has shown little utility in the treatment of BRAF V600E-mutant mCRC.

Binimetinib, encorafenib and cetuximab (BEACON Trial) combination therapy for patients with BRAF V600E-mutant metastatic colorectal cancer. [10.1358/dot.2019.55.11.3035584]


The analysis of larval zebrafish locomotor behavior has emerged as a powerful indicator of perturbations in the nervous system and is used in many fields of research, including neuroscience, toxicology and drug discovery.

Emergence of consistent intra-individual locomotor patterns during zebrafish development [10.1038/s41598-019-49614-y]


In conclusion, the zebrafish cardiac pacemaker has a limited temperature acclimation ability compared with known effects for other fishes and involves two pacemaking mechanisms, one of which was independent of temperature.

Membrane and calcium clock mechanisms contribute variably as a function of temperature to setting cardiac pacemaker rate in zebrafish Danio rerio. [10.1111/jfb.14126]


The adult zebrafish heart provides a powerful model in cardiac regeneration research.

Intrathoracic Injection for the Study of Adult Zebrafish Heart. [10.3791/59724]


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