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Circulation. Cardiovascular quality and outcomes
Research Hotspot & Journal Scope - Trials


Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.118.005420
Integrating Quality of Life and Survival Outcomes Cardiovascular Clinical Trials.

Jacob V Spertus · Laura A Hatfield · David J Cohen · Suzanne V Arnold · Martin Ho · Philip G Jones · Martin Leon · Bram Zuckerman · John A Spertus ·

Medicine
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Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.118.005095
Integrating Data From Randomized Controlled Trials and Observational Studies to Assess Survival in Rare Diseases

Adam Torbicki · Marisa Bacchi · Marion Delcroix · Harrison W Farber · Hossein-Ardeschir Ghofrani · Brian Hennessy · Pavel Jansa · Sanjay Mehta · Loïc Perchenet · Tomas Pulido · Daniel Rosenberg · Lewis J Rubin · B K S Sastry · Gérald Simonneau · Olivier Sitbon · Rogério Souza · Lee-Jen Wei · Richard Channick · Raymond Benza ·

Medicine
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Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/circoutcomes.119.005755
Fragility Index in Cardiovascular Randomized Controlled Trials.

Muhammad Shahzeb Khan · Rohan Kumar Ochani · Asim Shaikh · Muhammad Shariq Usman · Naser Yamani · Safi U Khan · M Hassan Murad · John Mandrola · Rami Doukky · Richard A Krasuski ·

Medicine
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This research is one of the first trials to evaluate the effectiveness of tailored nutritional counselling in treating malnutrition in outpatients with COPD.

The effectiveness of tailored dietary counselling in treating malnutrition in Vietnamese COPD outpatients: A randomised controlled trial [10.5204/thesis.eprints.135061]


However, more recent trials have demonstrated that abiraterone acetate is an option for treatment earlier in the prostate cancer paradigm.

Abiraterone acetate to treat metastatic castration-resistant prostate cancer in combination with prednisone. [10.1358/dot.2019.55.1.2914339]


Hence, there is a need for effective and reproducible neutralization protocols in chemical disinfection trials and practice.

A bioassay-based protocol for chemical neutralization of human faecal wastes treated by physico-chemical disinfection processes: A case study on benzalkonium chloride [10.1016/j.ijheh.2018.07.002]


ResultsAs a proof-of-concept, we identified examples of successes and failures of target-indication pairs in clinical trials across 875 targets and 574 disease indications to build a gold-standard data set of 6140 known clinical outcomes.

Predicting clinically promising therapeutic hypotheses using tensor factorization [10.1186/s12859-019-2664-1]


Patients with moderate to severe AD who received dupilumab treatment and achieved an Investigator's Global Assessment score of 0 or 1 or 75% improvement in Eczema Area and Severity Index scores (EASI-75) at week 16 in 2 previous dupilumab monotherapy trials (LIBERTY AD SOLO 1 and 2) were rerandomized in SOLO-CONTINUE.

Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis: A Randomized Clinical Trial. [10.1001/jamadermatol.2019.3617]


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