Circulation. Cardiovascular quality and outcomes

Research Hotspot & Journal Scope - Trials

Methods: Electronic databases were searched for eligible trials updated on November 2018.

Methods and Results: Our analysis included 10 785 black women enrolled in the Women’s Health Initiative Observational Study and Clinical Trials cohort.

endoscopes in transsphenoidal surgery reach opposite conclusions in their systematic reviews [2, 12]? Or why awake surgery enthusiasts reach different conclusions in systematic reviews on the impact of awake surgery than others [4, 14]? Or is this why radiotherapy usually reduces recurrence rates in atypical meningioma if studies are done by radiation oncologists [18, 20–22] but not necessarily if the studies are done by neurosurgeons [7, 13, 15, 17]? Is also our interpretation of the evidence different because we belong to different herds or genealogies where perhaps heretics are sanctioned and only accepted facts prevail? Does this make us read the scientific literature like the devil reads the bible? Is this why most vascular neurosurgeons refuse to believe results from the Aruba trial [16] or the Scottish AVM cohort study [1]? Or is this why many spine surgeons still like to fuse degenerative lumbar spines despite the negative trials [5, 6] (under the motto: screw the evidence)? The present study is an important reminder that not only traditional conflicts of interest matter, but our background, herd, or subspecialty might affect scientific results significantly.

Panjabi and Iskander suggest that the trials included in the NMA violated the similarity and consistency of assumptions in NMAs, leading to biased treatment effects.

However, in landmark head-to-head comparison trials, the thiazide-like diuretic chlorthalidone has been shown to be superior to ACE-I and CCB in decreasing left ventricle mass and preventing heart failure in hypertensive patients.