Last updated on 2022-01-26

Circulation. Cardiovascular quality and outcomes
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Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.118.005420

Integrating Quality of Life and Survival Outcomes Cardiovascular Clinical Trials.

Jacob V Spertus · Laura A Hatfield · David J Cohen · Suzanne V Arnold · Martin Ho · Philip G Jones · Martin Leon · Bram Zuckerman · John A Spertus ·

Medicine
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Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.118.005095

Integrating Data From Randomized Controlled Trials and Observational Studies to Assess Survival in Rare Diseases

Adam Torbicki · Marisa Bacchi · Marion Delcroix · Harrison W Farber · Hossein-Ardeschir Ghofrani · Brian Hennessy · Pavel Jansa · Sanjay Mehta · Loïc Perchenet · Tomas Pulido · Daniel Rosenberg · Lewis J Rubin · B K S Sastry · Gérald Simonneau · Olivier Sitbon · Rogério Souza · Lee-Jen Wei · Richard Channick · Raymond Benza ·

Medicine
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Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/circoutcomes.119.005755

Fragility Index in Cardiovascular Randomized Controlled Trials.

Muhammad Shahzeb Khan · Rohan Kumar Ochani · Asim Shaikh · Muhammad Shariq Usman · Naser Yamani · Safi U Khan · M Hassan Murad · John Mandrola · Rami Doukky · Richard A Krasuski ·

Medicine
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This research is one of the first trials to evaluate the effectiveness of tailored nutritional counselling in treating malnutrition in outpatients with COPD.

However, more recent trials have demonstrated that abiraterone acetate is an option for treatment earlier in the prostate cancer paradigm.

Hence, there is a need for effective and reproducible neutralization protocols in chemical disinfection trials and practice.

ResultsAs a proof-of-concept, we identified examples of successes and failures of target-indication pairs in clinical trials across 875 targets and 574 disease indications to build a gold-standard data set of 6140 known clinical outcomes.

Patients with moderate to severe AD who received dupilumab treatment and achieved an Investigator's Global Assessment score of 0 or 1 or 75% improvement in Eczema Area and Severity Index scores (EASI-75) at week 16 in 2 previous dupilumab monotherapy trials (LIBERTY AD SOLO 1 and 2) were rerandomized in SOLO-CONTINUE.

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