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Circulation. Cardiovascular quality and outcomes
Research Hotspot & Journal Scope - Inhibitors


Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.118.005404
Effect of Access to Prescribed PCSK9 Inhibitors on Cardiovascular Outcomes

Kelly D Myers · Niloofar Farboodi · Mkaya Mwamburi · William Howard · David Staszak · Samuel Gidding · Seth J Baum · Katherine Wilemon · Daniel J Rader ·

Medicine
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Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.119.005910
PCSK9 Inhibitors Prior Authorization.

Khurram Nasir · Suveen Angraal · Salim S Virani ·

Medicine
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Several potent and selective small-molecule inhibitors targeting CBP BrD have been reported, but thus far small-molecule inhibitors targeting BrD outside of the BrD and extraterminal domain (BET) family are especially lacking.

Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening [10.1038/s41401-019-0256-2]


We determined whether 3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A (HMG‐CoA) reductase inhibitors—statins, commonly prescribed to patients at risk of heart failure (HF)—can de‐differentiate myofibroblasts, alter cellular bioenergetics, and impact the human ventricular fibroblasts (hVFs) in HF patients.

Impact of statins on cellular respiration and de‐differentiation of myofibroblasts in human failing hearts [10.1002/ehf2.12509]


Patients taking SGLT-2 inhibitors were excluded because of the potential effect on circulating acetoacetate levels.

Prognostic value of biomarkers of impaired metabolism in heart failure patients with reduced ejection fraction [10.1016/j.ijcha.2019.100441]


Background/aim Tumour necrosis factor inhibitors and anti-interleukin-6 (anti-IL-6) therapies are increasingly being used in Takayasu’s arteritis (TA) patients who are unresponsive to corticosteroids ± conventional immunosuppressive agents.

Anti-interleukin-6 (tocilizumab) therapy in Takayasu’s arteritis: a real life experience [10.3906/sag-1906-39]


Compounds covered include glycine site agonists, glycine and system A-type transporter inhibitors, d-amino acid oxidase inhibitors, memantine and nicotinic alpha-7 acetylcholine receptor agonists.

N-methyl-d-aspartate-type glutamate receptor modulators and related medications for the enhancement of auditory system plasticity in schizophrenia [10.1016/j.schres.2018.02.003]


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