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Circulation. Cardiovascular quality and outcomes
Research Hotspot & Journal Scope - Inhibitors

Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.118.005404
Effect of Access to Prescribed PCSK9 Inhibitors on Cardiovascular Outcomes

Kelly D Myers · Niloofar Farboodi · Mkaya Mwamburi · William Howard · David Staszak · Samuel Gidding · Seth J Baum · Katherine Wilemon · Daniel J Rader ·

Circulation. Cardiovascular quality and outcomes - DOI: 10.1161/CIRCOUTCOMES.119.005910
PCSK9 Inhibitors Prior Authorization.

Khurram Nasir · Suveen Angraal · Salim S Virani ·


suggest another route for intervention on FD, based on the exploitation of epigenetic manipulation of cell metabolism via HDAC8 inhibitors [1].

Perils and Promises of Therapeutic Approaches for the Stem Cell Disease Fibrous Dysplasia [10.1002/sctm.18-0213]

As a class, ‘BET’ inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, especially super-enhancers, to inhibit gene transcription.

Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production [10.1038/s41598-019-46516-x]

IntroductionGlutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione.

Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer [10.1186/s13058-019-1141-0]

Therefore, the blockade of IL-1β production by using NLRP3 inflammasome inhibitors might be a novel potential strategy for the therapy and prevention of HMPV infection.

Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice [10.1371/journal.ppat.1007689]

The results showed that the antiscalant efficiency for both groups of inhibitors increases with elongation of methylene chain, but the longest compounds have a sharp drop in inhibition efficiency.

Study of various organophosphonate additives as calcium carbonate inhibitors for reverse osmosis [10.1051/E3SCONF/201910000001]

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