Virion Protein(病毒蛋白)研究综述
Virion Protein 病毒蛋白 - Although sensitive to IFN-I, novirhabdoviruses have nucleoprotein (N), matrix protein (M), and non-virion protein (NV) to interfere with host signal transduction and gene expression steps toward antiviral state establishment. [1] The p12 protein of Moloney murine leukemia virus (MMLV) is a virion protein that is critical for tethering the incoming viral DNA to host chromatin in the early stages of infection. [2] Proteomic analysis confirmed identification of virion proteins, along with low levels of assembly intermediates and host cell envelope proteins. [3] The sulfated fucans, which both lack anticoagulant activity, had similar antiviral profiles, suggesting that their activities are not only due to sulfation content or negative charge density but also due to other physicochemical factors such as the potential conformational shapes of these carbohydrates in solution and upon interaction with virion proteins. [4] In this study, we find that the half maximal inhibitory concentrations (IC50) of EOA on IHNV nucleoprotein (N), phosphoprotein (P), matrix protein (M), nonvirion protein (NV) and polymerase (L) mRNA expression is 0. [5] A small number of virion protein (VP) vaccine candidates are considered as the protective molecules in EV71 models. [6] The 11 kb viral genome encodes six proteins including nonvirion protein (NV). [7] Recent studies revealed putative genetic virulence markers of VHSV to rainbow trout highlighting the roles of the nucleoprotein, phosphoprotein and non-virion protein. [8] The long, flexible, and filamentous EBOV virion contains a central coiled nucleocapsid (NC) that comprises nucleoprotein NP and two cofactors, Virion protein (VP) 24 and VP35. [9] The most abundant rotavirion protein is VP6. [10] , GP, sGP, ssGP), nucleoproteins, virion proteins (i. [11] The virion protein (VP)1 gene sequence was amplified by reverse transcription polymerase chain reaction (RT-PCR) and sequenced. [12] Non-coding control region (NCCR) rearrangements and point mutations in virion protein (VP) 1 have been described in both JCPyV and BKPyV infections. [13] Using an existing clone of the trout-avirulent VHSV-IVb strain MI03 (pVHSVmi), eight chimeric VHSV clones were constructed in which the coding region(s) of the glycoprotein (G), non-virion protein (NV), G and NV, or G, NV and L (polymerase) genes together, were exchanged between the two clones. [14]尽管对 IFN-I 敏感，但新病毒弹状病毒具有核蛋白 (N)、基质蛋白 (M) 和非病毒粒子蛋白 (NV)，可干扰宿主信号转导和基因表达步骤，从而建立抗病毒状态。 [1] 莫洛尼鼠白血病病毒 (MMLV) 的 p12 蛋白是一种病毒体蛋白，对于在感染早期将传入的病毒 DNA 与宿主染色质联系起来至关重要。 [2] 蛋白质组学分析证实了病毒体蛋白的鉴定，以及低水平的组装中间体和宿主细胞包膜蛋白。 [3] 都缺乏抗凝活性的硫酸化海藻糖具有相似的抗病毒特性，这表明它们的活性不仅是由于硫酸盐含量或负电荷密度，而且还与其他物理化学因素有关，例如这些碳水化合物在溶液中的潜在构象形状。与病毒体蛋白的相互作用。 [4] 在本研究中，我们发现 EOA 对 IHNV 核蛋白 (N)、磷蛋白 (P)、基质蛋白 (M)、非病毒粒子蛋白 (NV) 和聚合酶 (L) mRNA 表达的半数最大抑制浓度 (IC50) 为 0。 [5] 少数病毒体蛋白 (VP) 候选疫苗被认为是 EV71 模型中的保护分子。 [6] 11kb 病毒基因组编码六种蛋白质，包括非病毒体蛋白 (NV)。 [7] 最近的研究揭示了 VHSV 对虹鳟鱼的推定遗传毒力标记，突出了核蛋白、磷蛋白和非病毒体蛋白的作用。 [8] 长而柔韧的丝状 EBOV 病毒粒子包含一个中心盘绕的核衣壳 (NC)，它包含核蛋白 NP 和两个辅助因子，病毒粒子蛋白 (VP) 24 和 VP35。 [9] 最丰富的轮状病毒蛋白是VP6。 [10] , GP, sGP, ssGP), 核蛋白, 病毒体蛋白 (i. [11] 通过逆转录聚合酶链反应（RT-PCR）扩增病毒体蛋白（VP）1基因序列并测序。 [12] 在 JCPyV 和 BKPyV 感染中都描述了病毒粒子蛋白 (VP) 1 中的非编码控制区 (NCCR) 重排和点突变。 [13] 使用鳟鱼无毒 VHSV-IVb 菌株 MI03 (pVHSVmi) 的现有克隆，构建了八个嵌合 VHSV 克隆，其中糖蛋白 (G)、非病毒蛋白 (NV)、G 和 NV 的编码区，或 G、NV 和 L（聚合酶）基因一起在两个克隆之间交换。 [14]
Phage Virion Protein 噬菌体病毒蛋白
The poor annotation of phage virion protein (PVP) is the bottleneck of many areas of viral research, such as viral phylogenetic analysis, viral host identification and antibacterial drug design. [1] The phage virion protein (PVP), a type of bacteriophage structural protein, is an essential material of the infectious viral particles and is responsible for multiple biological functions. [2] We have tested the method on four more datasets, namely the iAMP-2L dataset classifying antimicrobial peptides from non-antimicrobial peptides [5]; the tumor homing peptides dataset (TumorHPD); the HemoPI including hemolytic, non-hemolytic and semi-hemolytic peptides and the phage virion proteins. [3] Phage virion proteins (PVP) are essential materials of bacteriophage, which participate in a series of biological processes. [4] The improved method is applied to protein classification at the functional level, including identifying antimicrobial peptides, screening tumor homing peptides, and detecting hemolytic peptides and phage virion proteins. [5]噬菌体病毒体蛋白 (PVP) 的不良注释是病毒研究许多领域的瓶颈，例如病毒系统发育分析、病毒宿主鉴定和抗菌药物设计。 [1] 噬菌体病毒体蛋白（PVP）是一种噬菌体结构蛋白，是感染性病毒颗粒的重要物质，具有多种生物学功能。 [2] 我们已经在另外四个数据集上测试了该方法，即从非抗菌肽中分类抗菌肽的 iAMP-2L 数据集 [5]；肿瘤归巢肽数据集（TumorHPD）； HemoPI包括溶血、非溶血和半溶血肽和噬菌体病毒粒子蛋白。 [3] 噬菌体病毒体蛋白（PVP）是噬菌体的重要物质，参与一系列生物过程。 [4] 改进后的方法应用于功能水平的蛋白质分类，包括抗菌肽的鉴定、肿瘤归巢肽的筛选、溶血肽和噬菌体病毒体蛋白的检测。 [5]
Multifunctional Virion Protein
Ebolaviruses are non-segmented, negative-sense RNA viruses (NNSVs) within the order Mononegavirales that possess the multifunctional virion protein 35 (VP35), a major determinant of virulence and pathogenesis that is indispensable for viral replication and host innate immune evasion. [1] The multifunctional virion protein 35 (VP35) of ebolaviruses is a critical determinant of virulence and pathogenesis indispensable for viral replication and host innate immune evasion. [2]埃博拉病毒是单负链病毒目中的非分段负义 RNA 病毒 (NNSV)，具有多功能病毒粒子蛋白 35 (VP35)，这是病毒复制和宿主先天免疫逃避必不可少的毒力和发病机制的主要决定因素。 [1] 埃博拉病毒的多功能病毒体蛋白 35 (VP35) 是病毒复制和宿主先天免疫逃避必不可少的毒力和发病机制的关键决定因素。 [2]
Tagged Virion Protein
Using these predictive algorithms, lytic and non-lytic nuclei had the same levels of green fluorescent protein (GFP)-tagged virion proteins but lytic nuclei enriched the virion proteins faster, and collapsed more extensively upon laser-rupture than non-lytic nuclei, revealing impaired mechanical properties of lytic nuclei. [1] Phenotypic prediction and live-cell imaging revealed a faster enrichment of GFP-tagged virion proteins in lytic compared to nonlytic infected nuclei, and distinct mechanics of lytic and nonlytic nuclei upon laser-induced ruptures. [2]使用这些预测算法，裂解和非裂解核具有相同水平的绿色荧光蛋白 (GFP) 标记的病毒体蛋白，但裂解核更快地富集病毒体蛋白，并且在激光破裂时比非裂解核更广泛地塌陷，揭示溶解核的机械性能受损。 [1] 表型预测和活细胞成像显示，与非裂解性感染细胞核相比，裂解液中 GFP 标记的病毒体蛋白的富集速度更快，并且激光诱导破裂时裂解和非裂解性细胞核的不同机制。 [2]
Bacteriophage Virion Protein
In real applications, the function of the bacteriophage virion proteins is the main area of interest. [1] Bacteriophage virion proteins (BVPs) are bacterial viruses that have a great impact on different biological functions of bacteria. [2]在实际应用中，噬菌体病毒体蛋白的功能是主要关注领域。 [1] 噬菌体病毒体蛋白（BVPs）是对细菌的不同生物学功能有很大影响的细菌病毒。 [2]
virion protein 35
Ebolaviruses are non-segmented, negative-sense RNA viruses (NNSVs) within the order Mononegavirales that possess the multifunctional virion protein 35 (VP35), a major determinant of virulence and pathogenesis that is indispensable for viral replication and host innate immune evasion. [1] The multifunctional virion protein 35 (VP35) of ebolaviruses is a critical determinant of virulence and pathogenesis indispensable for viral replication and host innate immune evasion. [2]埃博拉病毒是单负链病毒目中的非分段负义 RNA 病毒 (NNSV)，具有多功能病毒粒子蛋白 35 (VP35)，这是病毒复制和宿主先天免疫逃避必不可少的毒力和发病机制的主要决定因素。 [1] 埃博拉病毒的多功能病毒体蛋白 35 (VP35) 是病毒复制和宿主先天免疫逃避必不可少的毒力和发病机制的关键决定因素。 [2]
virion protein icp5 病毒蛋白Icp5
In addition, the work reveals that the virion protein ICP5 (VP5) interacts with the dynein cofactor dynactin, while the UL37 protein interacts with the dynein intermediate chain (DIC). [1] In addition, the work reveals that the virion protein ICP5 (VP5) interacts with the dynein cofactor dynactin, while the UL37 protein interacts with the dynein intermediate chain (DIC). [2]此外，这项工作揭示了病毒粒子蛋白 ICP5 (VP5) 与动力蛋白辅因子 dynactin 相互作用，而 UL37 蛋白与动力蛋白中间链 (DIC) 相互作用。 [1] 此外，这项工作揭示了病毒粒子蛋白 ICP5 (VP5) 与动力蛋白辅因子 dynactin 相互作用，而 UL37 蛋白与动力蛋白中间链 (DIC) 相互作用。 [2]