Virion Morphogenesis(病毒体形态发生)研究综述
Virion Morphogenesis 病毒体形态发生 - In ZIKV-infected cells lipid metabolism attributed to intracellular membrane remodeling, virion morphogenesis, autophagy modulation, innate immunity and inflammation. [1] The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. [2] We employed a genetic approach to determine essential domains and amino acid residues of pUL37 and their associated functions in cellular localization and virion morphogenesis. [3] These classical scenarios give different timelines for the origin(s) of viruses and do not explain the provenance of the two key functional modules that are responsible, respectively, for viral genome replication and virion morphogenesis. [4] ABSTRACT In hepatocytes, PLIN2 is the major protein coating lipid droplets (LDs), an organelle the hepatitis C virus (HCV) hijacks for virion morphogenesis. [5] A strongly-detected sub-network of membrane proteins A17, H3, A27 and A26 represented an apparent interface of the early-forming virion envelope with structures added later during virion morphogenesis. [6] While multiple regions in the NTD and CTD are reported to play roles in virion morphogenesis and infectivity, the roles of the linker region in Gag assembly and virus particle formation remain elusive. [7] Here we present robust phylogenetic trees of NCLDVs, based on the 8 most conserved proteins responsible for virion morphogenesis and informational processes. [8] P318 has a double-stranded DNA genome of 48,045 base pairs with 3′-extended COS ends, on which 52 putative ORFs are organized into clusters responsible for the order of genome replication, virion morphogenesis, and the regulation of the lytic/lysogenic cycle. [9] For Flaviviridae members, the nonstructural proteins are essential for virion formation and thus exert a dual role in RNA replication and virion morphogenesis. [10] Coronavirus (CoV) envelope (E) protein is a small structural protein critical for virion morphogenesis and release. [11] These first cryo-EM images of the New World Orthohantavirus confirm prior EM observations that noted tubular projections of SNV at the plasma membrane during virion morphogenesis but were not confirmed. [12]在 ZIKV 感染的细胞中，脂质代谢归因于细胞内膜重塑、病毒粒子形态发生、自噬调节、先天免疫和炎症。 [1] 慢病毒 Gag 多蛋白的衣壳结构域 (CA) 在病毒粒子形态发生过程中具有两个不同的作用。 [2] 我们采用遗传方法来确定 pUL37 的基本结构域和氨基酸残基及其在细胞定位和病毒粒子形态发生中的相关功能。 [3] 这些经典场景给出了病毒起源的不同时间线，并没有解释分别负责病毒基因组复制和病毒粒子形态发生的两个关键功能模块的出处。 [4] 摘要 在肝细胞中，PLIN2 是主要的蛋白质涂层脂滴 (LDs)，是丙型肝炎病毒 (HCV) 劫持病毒粒子形态发生的细胞器。 [5] 强烈检测到的膜蛋白 A17、H3、A27 和 A26 子网络代表了早期形成的病毒粒子包膜的明显界面，其结构在病毒粒子形态发生过程中稍后添加。 [6] 虽然据报道 NTD 和 CTD 中的多个区域在病毒粒子形态发生和感染性中发挥作用，但接头区域在 Gag 组装和病毒颗粒形成中的作用仍然难以捉摸。 [7] 在这里，我们基于负责病毒体形态发生和信息过程的 8 种最保守的蛋白质，展示了 NCLDV 的强大系统发育树。 [8] P318 具有 48,045 个碱基对的双链 DNA 基因组，具有 3' 延伸的 COS 末端，其中 52 个推定的 ORF 被组织成簇，负责基因组复制的顺序、病毒粒子的形态发生和裂解/溶原循环的调节。 [9] 对于黄病毒科成员来说，非结构蛋白对于病毒粒子的形成至关重要，因此在 RNA 复制和病毒粒子形态发生中发挥双重作用。 [10] 冠状病毒 (CoV) 包膜 (E) 蛋白是一种对病毒粒子形态发生和释放至关重要的小结构蛋白。 [11] 新世界正汉坦病毒的这些第一批冷冻 EM 图像证实了先前的 EM 观察结果，即在病毒粒子形态发生过程中注意到质膜上的 SNV 管状投影，但未得到证实。 [12]