Testicular Teratoma(睾丸畸胎瘤)研究综述
Testicular Teratoma 睾丸畸胎瘤 - Testicular teratomas are described in horses, cats, dogs, wild boars, bulls, and humans. [1] In the present study, it was revealed that ML-IAP was expressed at high levels in testicular teratoma. [2] We describe a case of testicular teratoma with metastasis to the right ventricle. [3] Regarding the current World Health Organization (WHO) criteria, testicular teratomas are divided into prepubertal and post-pubertal subtypes based on patients’ age. [4] MOLF-Chr19 mouse model of testicular teratomas and a NANOS2 reporter allele, we report that the developmental phenotypes required for tumorigenesis, including failure to enter mitotic arrest, retention of pluripotency and delayed sex-specific differentiation, were exclusive to a subpopulation of germ cells failing to express NANOS2. [5] Testicular teratomas are derived from embryonic tissue within gonads and tend to exhibit locally invasive and chemo resistant behavior. [6] Although most testicular teratomas are benign, some immature cases include malignant transformation or the mixed type with yolk sac tumor and, occasionally, it is challenging to rule out malignancy. [7] Constantly improving ultrasound technologies facilitate prenatal detection of various fetal diseases, including low-incidence disorders that are typically diagnosed postnatally, such as testicular teratoma. [8] In this report, we are presenting a of testicular teratoma in an unilateral abdominal cryptorchid horse. [9] Mediastinal germ cell tumor, testicular teratoma, and radioulnar synostosis have been noted in 3 cases but not in this case. [10] A testicular teratoma is composed of mature embryonic tissue derived from at least 2 of the 3 germinal layers. [11] We present a case of a testicular teratoma with acoustic streaming. [12] Only 2–6% of testicular teratomas are pure teratomas. [13]睾丸畸胎瘤见于马、猫、狗、野猪、公牛和人类。 [1] 在本研究中，揭示了 ML-IAP 在睾丸畸胎瘤中高水平表达。 [2] 我们描述了一个睾丸畸胎瘤转移到右心室的病例。 [3] 根据目前世界卫生组织（WHO）的标准，睾丸畸胎瘤根据患者的年龄分为青春期前和青春期后的亚型。 [4] MOLF-Chr19 睾丸畸胎瘤小鼠模型和 NANOS2 报告等位基因，我们报告肿瘤发生所需的发育表型，包括未能进入有丝分裂停滞、多能性保留和延迟的性别特异性分化，是生殖细胞亚群失败的独有特征表达 NANOS2。 [5] 睾丸畸胎瘤来源于性腺内的胚胎组织，往往表现出局部侵袭性和化学抗性行为。 [6] 尽管大多数睾丸畸胎瘤是良性的，但一些未成熟的病例包括恶变或与卵黄囊肿瘤混合型，有时很难排除恶性肿瘤。 [7] 不断改进的超声技术有助于产前检测各种胎儿疾病，包括通常在产后诊断的低发病率疾病，例如睾丸畸胎瘤。 [8] 在本报告中，我们介绍了单侧腹部隐睾马的睾丸畸胎瘤。 [9] 纵隔生殖细胞瘤、睾丸畸胎瘤和尺桡骨关节突在 3 例中出现，但在本例中未发现。 [10] 睾丸畸胎瘤由来自 3 个生发层中的至少 2 个的成熟胚胎组织组成。 [11] 我们提出了一个带有声流的睾丸畸胎瘤病例。 [12] 只有 2-6% 的睾丸畸胎瘤是纯畸胎瘤。 [13]
Pure Testicular Teratoma 纯睾丸畸胎瘤
Following radical orchiectomy, surveillance and primary retroperitoneal lymph node dissection (RPLND) are acceptable options for the management of early stage pure testicular teratoma in adult patients; however, there is no uniform consensus. [1] In their study, ‘‘Retroperitoneal Lymph Node Dissection vs Surveillance for Adult Early-Stage Pure Testicular Teratoma: A Nationwide Analysis,’’ Ali et al. [2] We present the case of a 32 year old male patient diagnosed with a pure testicular teratoma in clinical stage I and a right renal cyst Bosniak IIF, as part of treatment he received chemotherapy, during which, radiological changes were observed at the level of renal cyst suggesting metastatic tumor. [3] In this study, we investigated clinical, morphological, and molecular criteria for distinguishing prepubertal-type teratoma from postpubertal-type teratoma in a prospective series of pure testicular teratomas. [4]根治性睾丸切除术后，监测和原发性腹膜后淋巴结清扫术 (RPLND) 是治疗成人早期纯睾丸畸胎瘤的可接受选择；但是，没有统一的共识。 [1] 在他们的研究中，“成人早期纯睾丸畸胎瘤的腹膜后淋巴结清扫与监测：全国性分析”，Ali 等人。 [2] 我们介绍了一名 32 岁男性患者的病例，在临床 I 期诊断为纯睾丸畸胎瘤和右侧肾囊肿 Bosniak IIF，作为治疗的一部分，他接受了化疗，在此期间，在肾囊肿水平观察到放射学变化提示转移瘤。 [3] 在这项研究中，我们在一系列前瞻性纯睾丸畸胎瘤中研究了区分青春期前型畸胎瘤和青春期后型畸胎瘤的临床、形态学和分子标准。 [4]