Temporally Programmed(临时编程)研究综述
Temporally Programmed 临时编程 - Until now, synthetic efforts have majorly contributed to fundamental strategies; however, temporally programmed functions are rarely explored. [1] To address this dilemma, genetic engineering of a body temperature‐responsive and matrix metalloproteinase (MMP)‐cleavable conjugate of interferon alpha (IFNα) and elastin‐like polypeptide (ELP) is reported with spatiotemporally programmed two‐step release kinetics for tumor therapy. [2] An efficacious temporally programmed combination therapy of extended half-life interleukin 2 (eIL2), tumor targeting antibody, and interferon (IFN) α was recently reported; however, tumor-ablative efficacy was associated with significant toxicity. [3] We also discuss key challenges and opportunities for translation of temporally programmed treatment schedules to the clinic, including alignment of immunological timescales in preclinical models and humans, and the use of current and emerging biomarkers. [4]到目前为止，综合努力对基本战略做出了重大贡献；然而，很少探索时间编程的功能。 [1] 为了解决这一难题，报道了一种具有体温响应性和基质金属蛋白酶 (MMP) 可切割的干扰素 α (IFNα) 和弹性蛋白样多肽 (ELP) 偶联物的基因工程，该偶联物具有时空编程的两步释放动力学，用于肿瘤治疗。 [2] 最近报道了延长半衰期白细胞介素 2 (eIL2)、肿瘤靶向抗体和干扰素 (IFN) α 的有效时间程序化联合疗法；然而，肿瘤消融功效与显着毒性相关。 [3] 我们还讨论了将时间编程的治疗计划转化为临床的关键挑战和机遇，包括临床前模型和人类中免疫学时间尺度的对齐，以及当前和新兴生物标志物的使用。 [4]