Subclinical Diabetic(亚临床糖尿病)研究综述
Subclinical Diabetic 亚临床糖尿病 - Objective: To estimate the diagnostic value of fibronectin type Ⅲ-domain containing protein 5 (FNDC5) in subclinical diabetic cardiomyopathy. [1] We investigated the association of GV with subclinical diabetic polyneuropathy in a large-scale sample of patients with type 2 diabetes. [2] Proper detection of subclinical diabetic neuropathy is important to prevent more complications. [3] Background Three-dimensional (3D) speckle tracking echocardiography can identify subclinical diabetic cardiomyopathy without geometric assumption and loss of speckle from out-of-plane motions. [4] High resolution sonography detected nerve changes with a good accuracy, and thus, can be a potential screening tool for detection of subclinical diabetic polyneuropathy. [5] 014°/µm) mean total birefringence of peripapillary RNFL was significantly reduced in subclinical diabetic eyes (0. [6] Present study concluded that miRNA could be regarded as a novel biomarker and plays a valuable role, alongside GLS echocardiographic assessment, for early detection of subclinical diabetic cardiomyopathy. [7] Elevated fibroblast growth factor 21(FGF21) was suggested in cross-sectional studies as an indicator of subclinical diabetic nephropathy. [8] So, that the term “Subclinical diabetic retinopathy” was suggestible to refer to a clinical state where the FAZ metrics, vascular density and perfusion density showed a particular deviation from the normal healthy parameters. [9] Purpose The aim of this study was to compare between patients with subclinical diabetic retinopathy (DR) and healthy individuals in the retinal microvascular changes including vascular density (VD), perfusion density (PD), and foveal avascular zone (FAZ) parameters by using optical coherence tomography angiography (OCTA). [10] From the present study we found that left ventricular strain and strain rate by conventional echo could reveal the presence of subclinical diabetic cardiomyopathy. [11] Conclusion: Diabetic patients with subclinical diabetic retinopathy feature a larger foveal avascular zone at the superficial capillary plexus compared with controls, as well as relative reduction of the vessel density at the deep capillary plexus. [12]目的：评估含纤连蛋白Ⅲ型结构域蛋白5（FNDC5）在亚临床糖尿病心肌病中的诊断价值。 [1] 我们在大规模 2 型糖尿病患者样本中调查了 GV 与亚临床糖尿病性多发性神经病的关系。 [2] 正确检测亚临床糖尿病神经病变对于预防更多并发症很重要。 [3] 背景 三维 (3D) 散斑跟踪超声心动图可以识别亚临床糖尿病性心肌病，而无需几何假设和平面外运动引起的散斑丢失。 [4] 高分辨率超声以良好的准确性检测到神经变化，因此可以成为检测亚临床糖尿病多发性神经病的潜在筛查工具。 [5] 014°/µm) 平均视乳头周围 RNFL 的总双折射在亚临床糖尿病患者眼中显着降低 (0. [6] 目前的研究得出结论，miRNA 可以被视为一种新的生物标志物，并与 GLS 超声心动图评估一起在亚临床糖尿病心肌病的早期检测中发挥重要作用。 [7] 横断面研究表明，成纤维细胞生长因子 21 (FGF21) 升高是亚临床糖尿病肾病的指标。 [8] 因此，“亚临床糖尿病性视网膜病变”一词可用于指代 FAZ 指标、血管密度和灌注密度与正常健康参数有特定偏差的临床状态。 [9] 目的 本研究的目的是比较亚临床糖尿病视网膜病变 (DR) 患者和健康个体的视网膜微血管变化，包括血管密度 (VD)、灌注密度 (PD) 和中心凹无血管区 (FAZ) 参数。相干断层扫描血管造影（OCTA）。 [10] 从目前的研究中我们发现，常规回波的左心室应变和应变率可以揭示亚临床糖尿病心肌病的存在。 [11] 结论：与对照组相比，患有亚临床糖尿病视网膜病变的糖尿病患者在浅表毛细血管丛处的中心凹无血管区比对照组更大，并且在深部毛细血管丛处的血管密度相对降低。 [12]
subclinical diabetic cardiomyopathy 亚临床糖尿病心肌病
Objective: To estimate the diagnostic value of fibronectin type Ⅲ-domain containing protein 5 (FNDC5) in subclinical diabetic cardiomyopathy. [1] Background Three-dimensional (3D) speckle tracking echocardiography can identify subclinical diabetic cardiomyopathy without geometric assumption and loss of speckle from out-of-plane motions. [2] Present study concluded that miRNA could be regarded as a novel biomarker and plays a valuable role, alongside GLS echocardiographic assessment, for early detection of subclinical diabetic cardiomyopathy. [3] From the present study we found that left ventricular strain and strain rate by conventional echo could reveal the presence of subclinical diabetic cardiomyopathy. [4]目的：评估含纤连蛋白Ⅲ型结构域蛋白5（FNDC5）在亚临床糖尿病心肌病中的诊断价值。 [1] 背景 三维 (3D) 散斑跟踪超声心动图可以识别亚临床糖尿病性心肌病，而无需几何假设和平面外运动引起的散斑丢失。 [2] 目前的研究得出结论，miRNA 可以被视为一种新的生物标志物，并与 GLS 超声心动图评估一起在亚临床糖尿病心肌病的早期检测中发挥重要作用。 [3] 从目前的研究中我们发现，常规回波的左心室应变和应变率可以揭示亚临床糖尿病心肌病的存在。 [4]
subclinical diabetic retinopathy
So, that the term “Subclinical diabetic retinopathy” was suggestible to refer to a clinical state where the FAZ metrics, vascular density and perfusion density showed a particular deviation from the normal healthy parameters. [1] Purpose The aim of this study was to compare between patients with subclinical diabetic retinopathy (DR) and healthy individuals in the retinal microvascular changes including vascular density (VD), perfusion density (PD), and foveal avascular zone (FAZ) parameters by using optical coherence tomography angiography (OCTA). [2] Conclusion: Diabetic patients with subclinical diabetic retinopathy feature a larger foveal avascular zone at the superficial capillary plexus compared with controls, as well as relative reduction of the vessel density at the deep capillary plexus. [3]因此，“亚临床糖尿病性视网膜病变”一词可用于指代 FAZ 指标、血管密度和灌注密度与正常健康参数有特定偏差的临床状态。 [1] 目的 本研究的目的是比较亚临床糖尿病视网膜病变 (DR) 患者和健康个体的视网膜微血管变化，包括血管密度 (VD)、灌注密度 (PD) 和中心凹无血管区 (FAZ) 参数。相干断层扫描血管造影（OCTA）。 [2] 结论：与对照组相比，患有亚临床糖尿病视网膜病变的糖尿病患者在浅表毛细血管丛处的中心凹无血管区比对照组更大，并且在深部毛细血管丛处的血管密度相对降低。 [3]
subclinical diabetic polyneuropathy 亚临床糖尿病多发性神经病
We investigated the association of GV with subclinical diabetic polyneuropathy in a large-scale sample of patients with type 2 diabetes. [1] High resolution sonography detected nerve changes with a good accuracy, and thus, can be a potential screening tool for detection of subclinical diabetic polyneuropathy. [2]我们在大规模 2 型糖尿病患者样本中调查了 GV 与亚临床糖尿病性多发性神经病的关系。 [1] 高分辨率超声以良好的准确性检测到神经变化，因此可以成为检测亚临床糖尿病多发性神经病的潜在筛查工具。 [2]