Serum Marker(血清标志物)研究综述
Serum Marker 血清标志物 - Bone histomorphmetry of the proximal tibia further revealed that Phlpp1 cKOLysM females exhibited elevated osteoclast numbers, but conversely had reduced levels of serum markers of bone resorption as compared to littermate controls. [1] to study the relationship of left ventricular (LV) mechanics with the level of serum markers of myocardial fibrosis in patients with epicardial obesity (EO). [2] Methods In this cohort study we evaluated the association between a serum marker of muscle damage [creatine phosphokinase (CPK)] and isometric strength of the adductor muscles of the hip in 30 professional football players (age: 26. [3] Dual X-ray absorptiometry (DEXA) is the commonly used modality for diagnosis osteoporosis; serum markers have been suggested for predicting osteoporosis and discriminate osteoporotic from healthy subjects. [4] A manual method was used to determine the full blood cell count, while Randox kit was used to estimate the serum markers of liver and kidney functions. [5] Portal vein tumor thrombosis (PVTT) is associated with aggressive tumor biology (high grade), high tumor burden (number and size of lesions), high levels of serum markers (AFP), poor liver function (deranged LFT), and poor performance status of patients. [6] Preoperative/postoperative complications (dehiscence, wound infection, bone non-union, osteomyelitis, flap failure) were monitored with clinical signs, imaging, and serum markers (CRP, WBC). [7] In Step 1, we tested whether serum markers of cholesterol catabolism were associated with brain amyloid accumulation, white matter lesions (WMLs), and brain atrophy. [8] Low testosterone (T) is a serum marker of hypogonadism. [9] However, we found clear differences in early dcSSc analysed by major ANA subset for longitudinal change in serum markers of fibrosis and in whole skin gene expression, suggesting a mechanistic basis for the distinct clinical phenotypes associated with hallmark ANAs. [10] Methods The serum markers of 160 RM-NPC patients were measured before and three weeks after the first anti-PD-1 treatment. [11] The Levels of serum marker enzymes i. [12] The use of TE with other serum markers can be helpful for the diagnosis of advanced fibrosis. [13] Materials and methods: Detailed history, sociodemographic prole and serum markers including Hb, Lipid prole, ALT, AST, FBS, hsCRP, Fasting insulin level were estimated in 200 patients of Metabolic Syndrome (NCEP ATP III) at the Department of Medicine, NRS Medical College & Hospital, Kolkata from August 2019 to August 2020. [14] NO was the only serum marker that showed significant changes in both groups. [15] Parameters related to bone health, including BMD, TBS, and serum markers of calcium homeostasis, were assessed at baseline and after one year of treatment. [16] Serum markers of myocardial injury (troponin I, NT-proBNP) were measured in both groups of patients in the preoperative period before training (point 1), at the end of exercise training session (point 2) and at days 5-7 (point 3) after CABG. [17] Urinary levels of candidate molecular markers appear to reflect SSc–CKD more than serum markers. [18] BACKGROUND This study aimed to assess the baseline levels of D-dimer, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) and monitor the natural course of these serum markers after uneventful primary total joint arthroplasty. [19] We aimed to assess patients with axial spondyloarthritis (axSpA) and inflammatory bowel disease (IBD) for disease activity and serum markers of endothelial dysfunction. [20] High-fat diet-fed C57BL/6J mice when treated with 28-HB (1-20 µg/day) for 6 weeks exhibited a marked decrease in aortic fat deposit and serum marker levels. [21] Individuals were assessed using lactulose breath testing, serum markers for enterocyte damage and bacterial translocation, and the Chronic Liver Disease Questionnaire (CLDQ) prior to and after completion of the treatment phase. [22] We investigated correlations between serum markers and AECOPD. [23] RESULTS The correlation (r) between Uhep/UCr and serum markers of iron status (ferritin and zinc protoporphyrin-to-heme ratio (ZnPP/H)) and iron dose was assessed. [24] Currently, the evaluation of the glycemic profile relies on serum markers (glycated hemoglobin HbA1c, glycated albumin, and fructosamine), capillary glucose blood control (self-monitoring of blood glucose), and interstitial glucose control (continue glucose monitoring). [25] Serum markers including 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor-19 (FGF-19) were validated in adults to detect bile acid diarrhea (BAD) compared to 48-hour fecal bile acid collection (48FBA). [26] All values were compared with serum markers. [27] This guideline provides recommendations for multiple dimensions of clinical management for CNS GCTs, with particular focus on diagnostic measures including serum markers, treatment algorithms including surgery, radiotherapy and chemotherapy, and under-investigated but important areas such as treatment for recurrent cases, long-term follow-up protocols and long-term sequelae. [28] We measured these serum markers in participants with obesity/overweight and prediabetes from the New Zealand arm of the PREVIEW lifestyle intervention randomised trial before and after an 8-week low energy diet (LED). [29] BACKGROUND AND OBJECTIVES Transcriptomic landscape of prostate cancer (PCa) shows multidimensional variability, potentially arising from the cell-of-origin, reflected in serum markers, and most importantly related to drug sensitivities. [30] Based on ideal body composition, PFS were computed as previously published for all subjects and compared with serum markers. [31] Changes in serum markers (CRP, D –dimer, S ferritin) will be other secondary outcomes. [32] Urinary iodine concentration (UIC), serum markers of thyroid function, aortic augmentation index, and pulse wave velocity (PWV) were compared. [33] Multiple variable analysis was performed to assess the predictability of disease activity by serum markers included in the study. [34] Changes in serum markers (CRP, D –dimer, S ferritin) will be other secondary outcomes. [35] Data were collected by a questionnaire, and blood samples of patients in terms of serum markers HCV-Ab, HBsAg and HBs-Ab were analyzed by ELISA, and positive HCV-Ab results were confirmed by Real Time-PCR. [36] Serum markers were elevated and CT scan of the abdomen showed thickening of a part of the jejunum wall with swollen lymph nodes in the mesentery, along the inferior vena cava and abdominal aorta, in the retroperitoneal space. [37] This study aimed to investigate the effect of Lactobacillus plantarum on growth traits, slaughter performance, serum markers and intestinal bacterial community of Daheng broilers. [38] These observations led to the conclusion that profiles of CRS, including its duration, severity and serum markers are correlated to the incidence and recovery of new-onset severe cytopenia, prompting clinical intervention for post-CAR-T severe cytopenia. [39] Demographics, serum markers, radiological and sampling results of these 123 patients were collected to construct a nomogram using multivariate analysis. [40] Serum markers for energy metabolism and proteins were evaluated and liver enzymes were measured. [41] Serum markers of bone turnover were determined using enzyme-linked immunosorbent assay (ELISA). [42] CONCLUSION A more reliable and specific signature of miRNAs is expected with forthcoming studies in samples from HCM patients and correlation of miRNAs with CMR and serum markers of fibrosis may implicate novel diagnostic and therapeutic pathways. [43] METHODS We performed a prospective study comparing 68 CHA patients, angioedema without hives, with 63 CSU patients, with hives and angioedema, from whom we collected demographic and clinical data, as well as blood and serum markers. [44] Objective: The purpose of this study was to compare the performance of serum marker – based indices and portal vein diameter assessed by ultrasound in patients of portal hypertension due to liver cirrhosis in prediction of large esophageal varices, graded on endoscopy. [45] To date, there has been no specific test or serum marker to measure and determine the severity of BD, and diagnosis remains based on clinical findings. [46] We aimed to study the possible association of stress hyperglycemia in COVID-19 critically ill patients with prognosis, artificial nutrition, circulating osteocalcin, and other serum markers of inflammation and compare them with non-COVID-19 patients. [47] The in vivo application of PG pre-activated implant significantly increased the percentage of CD4 + and CD8 + cells, while decreasing the percentage of Gr1 + , CD25 + , CD11b + , Foxp3 + cells, and arginase-1 activity in the spleen of LPS-treated animals, as well as all serum markers tested, allowing survival and rescuing the severity of sepsis phenotype. [48] At present, alpha fetoprotein (AFP) is mainly used as a serum marker of primary Hepatocellular carcinoma. [49] AIM To clarify the efficacy of effective CPAP therapy on NAFLD of OSA patients by serum markers and transient elastography (TE) using FibroScan® (Echosens, Paris, France). [50]胫骨近端的骨组织形态学进一步显示，与同窝对照相比，Phlpp1 cKOLysM 雌性雌性破骨细胞数量增加，但相反，骨吸收血清标志物水平降低。 [1] 研究心外膜肥胖（EO）患者左心室（LV）力学与心肌纤维化血清标志物水平的关系。 [2] 方法 在这项队列研究中，我们评估了 30 名职业足球运动员（年龄：26. [3] 双X线骨密度仪（DEXA）是诊断骨质疏松症的常用方法；血清标志物已被建议用于预测骨质疏松症并将骨质疏松症与健康受试者区分开来。 [4] 全血细胞计数采用人工方法测定，肝肾功能血清标志物测定采用Randox试剂盒。 [5] 门静脉肿瘤血栓形成 (PVTT) 与侵袭性肿瘤生物学（高级别）、高肿瘤负荷（病变的数量和大小）、高水平的血清标志物 (AFP)、肝功能差（异常 LFT）和较差的体能状态相关的患者。 [6] 通过临床体征、影像学和血清标志物（CRP、WBC）监测术前/术后并发症（裂开、伤口感染、骨不愈合、骨髓炎、皮瓣失败）。 [7] 在第 1 步中，我们测试了胆固醇分解代谢的血清标志物是否与脑淀粉样蛋白积累、白质病变 (WML) 和脑萎缩相关。 [8] 低睾酮 (T) 是性腺机能减退的血清标志物。 [9] 然而，我们发现主要 ANA 子集分析的早期 dcSSc 在纤维化血清标志物和整个皮肤基因表达的纵向变化方面存在明显差异，这表明与标志性 ANA 相关的不同临床表型的机制基础。 [10] 方法 对 160 例 RM-NPC 患者在首次抗 PD-1 治疗前后 3 周进行血清标志物检测。 [11] 血清标志酶水平 i． [12] TE 与其他血清标志物的使用有助于诊断晚期纤维化。 [13] 材医学，NRS 医学院和医院，加尔各答，2019 年 8 月至 2020 年 8 月。 [14] NO是两组中唯一显示出显着变化的血清标志物。 [15] 在基线和治疗一年后评估与骨骼健康相关的参数，包括 BMD、TBS 和钙稳态血清标志物。 [16] 在训练前（第 1 点）、运动训练结束时（第 2 点）和第 5-7 天（第 5-7 天）测量两组患者的心肌损伤血清标志物（肌钙蛋白 I、NT-proBNP） 3) CABG 后。 [17] 候选分子标志物的尿液水平似乎比血清标志物更能反映 SSc-CKD。 [18] 背景 本研究旨在评估 D-二聚体、C-反应蛋白 (CRP) 和红细胞沉降率 (ESR) 的基线水平，并监测这些血清标志物在顺利初次全关节置换术后的自然过程。 [19] 我们旨在评估患有中轴型脊柱关节炎 (axSpA) 和炎症性肠病 (IBD) 的患者的疾病活动性和内皮功能障碍的血清标志物。 [20] 用 28-HB（1-20 µg/天）处理 6 周的高脂肪饮食喂养的 C57BL/6J 小鼠表现出主动脉脂肪沉积和血清标志物水平的显着降低。 [21] 在治疗阶段完成之前和之后，使用乳果糖呼气测试、肠细胞损伤和细菌易位的血清标志物以及慢性肝病问卷 (CLDQ) 对个体进行评估。 [22] 我们调查了血清标志物与 AECOPD 之间的相关性。 [23] 结果 评估了 Uhep/UCr 与铁状态血清标志物（铁蛋白和锌原卟啉与血红素的比率 (ZnPP/H)）和铁剂量之间的相关性 (r)。 [24] 目前，血糖谱的评估依赖于血清标志物（糖化血红蛋白 HbA1c、糖化白蛋白和果糖胺）、毛细血管血糖控制（血糖的自我监测）和间质血糖控制（持续血糖监测）。 [25] 与 48 小时粪便胆汁酸收集相比，在成人中验证了包括 7α-羟基-4-cholesten-3-one (C4) 和成纤维细胞生长因子-19 (FGF-19) 在内的血清标志物检测胆汁酸腹泻 (BAD)。 48FBA)。 [26] 所有值均与血清标志物进行比较。 [27] 本指南为 CNS GCT 的多方面临床管理提供了建议，特别关注包括血清标志物在内的诊断措施，包括手术、放疗和化疗在内的治疗算法，以及研究不足但重要的领域，如复发病例的治疗、长期后续方案和长期后遗症。 [28] 我们在为期 8 周的低能量饮食 (LED) 之前和之后测量了来自 PREVIEW 生活方式干预随机试验新西兰分部的肥胖/超重和糖尿病前期参与者的这些血清标志物。 [29] 背景和目标 前列腺癌 (PCa) 的转录组学表现出多维变异性，可能源自细胞来源，反映在血清标志物上，最重要的是与药物敏感性有关。 [30] 基于理想的身体成分，按先前公布的所有受试者的 PFS 计算并与血清标志物进行比较。 [31] 血清标志物（CRP、D-二聚体、S 铁蛋白）的变化将是其他次要结果。 [32] 比较尿碘浓度（UIC）、甲状腺功能血清标志物、主动脉增强指数和脉搏波速度（PWV）。 [33] 进行多变量分析以评估研究中包括的血清标志物对疾病活动的可预测性。 [34] 血清标志物（CRP、D-二聚体、S 铁蛋白）的变化将是其他次要结果。 [35] 通过问卷调查收集数据，并通过ELISA分析患者血液样本中血清标志物HCV-Ab、HBsAg和HBs-Ab，并通过Real Time-PCR确认HCV-Ab阳性结果。 [36] 血清标志物升高，腹部 CT 扫描显示部分空肠壁增厚，肠系膜、下腔静脉和腹主动脉沿腹膜后间隙淋巴结肿大。 [37] 本研究旨在探讨植物乳杆菌对大横肉鸡生长性状、屠宰性能、血清标志物和肠道细菌群落的影响。 [38] 这些观察得出的结论是，CRS 的特征，包括其持续时间、严重程度和血清标志物与新发严重血细胞减少症的发生率和恢复相关，促使临床干预 CAR-T 后严重血细胞减少症。 [39] 收集这 123 名患者的人口统计学、血清标志物、放射学和采样结果，使用多变量分析构建列线图。 [40] 评估了能量代谢和蛋白质的血清标志物，并测量了肝酶。 [41] 使用酶联免疫吸附试验（ELISA）测定骨转换的血清标志物。 [42] 结论 随着即将对来自 HCM 患者的样本进行的研究，预计 miRNA 的更可靠和特异性特征，并且 miRNA 与 CMR 和纤维化血清标志物的相关性可能暗示新的诊断和治疗途径。 [43] 方法 我们进行了一项前瞻性研究，比较了 68 名 CHA 患者（无荨麻疹的血管性水肿）和 63 名患有荨麻疹和血管性水肿的 CSU 患者，我们从中收集了人口统计学和临床数据，以及血液和血清标志物。 [44] 目的：本研究的目的是比较基于血清标志物的指标和超声评估的门静脉直径在肝硬化门静脉高压患者中预测食管大静脉曲张（内镜分级）的性能。 [45] 迄今为止，还没有特定的测试或血清标志物来测量和确定 BD 的严重程度，诊断仍然基于临床发现。 [46] 我们旨在研究 COVID-19 重症患者的应激性高血糖与预后、人工营养、循环骨钙素和其他炎症血清标志物的可能关联，并将其与非 COVID-19 患者进行比较。 [47] PG预活化植入物的体内应用显着增加了LPS脾脏中CD4 + 和CD8 + 细胞的百分比，同时降低了Gr1 + 、CD25 + 、CD11b + 、Foxp3 + 细胞和精氨酸酶-1活性的百分比- 治疗的动物，以及测试的所有血清标志物，允许存活并挽救败血症表型的严重性。 [48] 目前，甲胎蛋白（AFP）主要用作原发性肝细胞癌的血清标志物。 [49] 目的通过血清标志物和使用 FibroScan® (Echosens, Paris, France) 的瞬时弹性成像 (TE) 阐明有效 CPAP 治疗对 OSA 患者 NAFLD 的疗效。 [50]
magnetic resonance imaging
Methods In a prospective cohort study, we compared responses to a single bout of resistance exercise by serum markers of muscle damage and quantitative muscle magnetic resonance imaging (MRI) in patients (n=12) and age- and gender-matched healthy controls (n=12). [1] This study aimed to determine if serum markers of neural origin are related to i) presence and severity of SCI, and ii) magnetic resonance imaging (MRI) parameters in the very acute post-injury phase. [2] In this review, we discuss current knowledge around the use of non-invasive methods to assess liver disease, such as abdominal ultrasound, controlled attenuation parameter, transient elastography, magnetic resonance imaging, and indices based on serum markers of liver injury. [3]方法 在一项前瞻性队列研究中，我们通过肌肉损伤的血清标志物和定量肌肉磁共振成像 (MRI) 在患者 (n=12) 和年龄和性别匹配的健康对照 (n= 12）。 [1] 本研究旨在确定神经起源的血清标志物是否与 i) SCI 的存在和严重程度以及 ii) 非常急性损伤后阶段的磁共振成像 (MRI) 参数有关。 [2] nan [3]
glomerular filtration rate
The objective of this study was to assess serum cystatin C (sCys C) levels in patients with urothelial carcinoma and to explore its clinical value as a serum marker of glomerular filtration rate (GFR). [1] As cystatin C is not subject to muscular conditions and is a sensitive serum marker in preclinical renal disease, we aimed to investigate the association between estimated glomerular filtration rate (eGFR) based on cystatin C and muscle strength in the Chinese population. [2] Serum indices based on creatinine and cystatin C, including creatinine/cystatin C ratio (Cr/CysC), ratio and difference of estimated glomerular filtration rate (eGFR) based on cystatin C and creatinine (eGFRcys/eGFRcre and eGFRDiff), and serum creatinine × eGFRcys, are recently identified serum markers for sarcopenia. [3]本研究的目的是评估尿路上皮癌患者的血清胱抑素 C (sCys C) 水平，并探讨其作为肾小球滤过率 (GFR) 血清标志物的临床价值。 [1] 由于胱抑素 C 不受肌肉状况的影响，并且是临床前肾病的敏感血清标志物，我们旨在研究基于胱抑素 C 的估计肾小球滤过率 (eGFR) 与中国人群肌肉力量之间的关联。 [2] nan [3]