Selectively Kills(选择性杀死)研究综述
Selectively Kills 选择性杀死 - Importantly, it selectively kills senescent cells upon application at higher concentrations, mainly by enhancing production of reactive oxygen species (ROS) and disturbing mitochondrial membrane potential, processes accompanied by upregulation of Bcl-2 family pro-apoptotic factors Puma and Noxa in senescent cells. [1] The action of Caffeic Acid on metabolic processes selectively kills cancer but not normal cells. [2] pseudintermedius selectively kills macrophages during abscess formation thereby antagonizing crucial host immune cell responses. [3] Herein, we show that TQ selectively kills DLBCL cells, either cell lines or primary lymphoma cells bearing resistance features to standard treatment. [4] Through high-throughput small molecule screens we identified the antibiotic Novobiocin (NVB) as a specific POLθ inhibitor that selectively kills HR-deficient tumor cells in vitro and in vivo. [5] Conclusion: PNC-27 selectively kills colon cancer stem cells by binding of this peptide to membrane H/MDM-2. [6] Results: The IL2‐R336A fusion protein selectively kills immunosuppressive Tregs that express the IL‐2 receptor while having little to no effect on cells negative for this target. [7] Inhibition of PLK1 selectively kills cancer cells and upregulates PD-L1 expression in surviving cancer cells thereby providing opportunity for ARAC targeted delivery in a positive feedback manner. [8] Cold atmospheric plasma (CAP) holds promise as a cancer-specific treatment agent that selectively kills basal-like/TN breast cancer cells. [9] We demonstrate that this therapy not only selectively kills tumours but also triggers pro-immunogenic signals from the tumour to attract immune cells. [10] We show for the first time that in vitro, TCBZ selectively kills methicillin-sensitive and methicillin-resistant Staphylococcus aureus and Staphylococcus pseudintermedius at a minimum inhibitory concentration (MIC) range of 2–4 µg/mL, and vancomycin-resistant enterococci at a MIC range of 4–8 µg/mL. [11] STATEMENT OF SIGNIFICANCE: This study describes a local injection of senolytic drug-loaded nanoparticles that selectively kills stress-induced senescent cells (SISCs) in infarcted heart. [12] Importantly, it selectively kills senescent cells upon application at higher concentrations, mainly by enhancing production of reactive oxygen species (ROS) and disturbing mitochondrial membrane potential, processes accompanied by upregulation of Bcl-2 family pro-apoptotic factors Puma and Noxa in senescent cells. [13] Previously, we showed that the BCL2 inhibitor venetoclax selectively kills acutely HIV-infected cells and reduces HIV DNA in latently infected CD4 T cells ex vivo after reactivation with anti-CD3/anti-CD28. [14] Mdr2-/- mice were also treated with fisetin, a flavonoid molecule that selectively kills senescent cells. [15] An oxo(corrolato)chromium(v) complex selectively kills leukemia cells. [16] This bacterium renders mosquitoes resistant to infection by the human parasite Plasmodium falciparum or the rodent parasite Plasmodium berghei via secretion of a lipase that selectively kills parasites at various stages. [17] When NTR-expressing larvae are treated with the prodrug metronidazole, the reaction between NTR and Mtz results in a toxic metabolite which selectively kills NTR-expressing cells. [18] Conclusion Magnetic hyperthermia using DCIONs selectively kills Y79 cells at 0. [19] A cell permeable peptide harboring the L126-Y133 sequence inhibited PCNA function in cancer cells and selectively kills cancer cells and xenograft tumors. [20] Background: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively kills tumor cells in cancer patients. [21] We show that appropriate linkage of the kis gene to a single, fully complementary, target site for an oncogenic human microRNA enables the construction of a synthetic toxin-antitoxin pair that selectively kills cancer cells overexpressing that particular microRNA. [22] Finally, we also discuss possible implications for improving health-span and life-span, as Azithromycin is an anti-aging drug that behaves as a senolytic, which selectively kills and removes senescent fibroblasts. [23] As AMPs are positively charged molecules that recognize negatively charged molecules exposed on the cell surface of pathogens during infection, Parvy et al hypothesized that the AMP selectively kills tumor cells while sparing normal cells by using a similar mechanism. [24] We concluded that mHDM2 represents a novel and unique therapeutic target, and targeting mHDM2 using PNC-27 selectively kills AML cells, including LSCs, with minimal off-target hematopoietic toxicity. [25] Immunoproteasome inhibition selectively kills human monocytes. [26] SIGNIFICANCE: This study identifies PMPCB as critical to mitochondrial homeostasis and a synthetic lethal candidate that selectively kills highly resistant EpCAM+ HCC tumors by inactivating the Wnt/β-catenin signaling pathway. [27] Recently, NFX was identified as a potent inhibitor of aldehyde dehydrogenase (ALDH)1 that selectively kills ALDHhigh cancer-initiating cells. [28] Clindamycin (CL) is an antibiotic that selectively kills anaerobic bacteria, and accordingly Bacteroidetes are completely eradicated from CL-treated mouse intestines. [29] Recently, a new class of non-platinum-based halogenated molecules (called FMD compounds) was discovered that selectively kills cancer cells. [30] Using genetic and chemical approaches, we showed that hyperactivation of the protease selectively kills cancer cells, independently of p53 status, by selective degradation of its respiratory chain protein substrates and disrupts mitochondrial structure and function, while it does not affect non-malignant cells. [31] Mechanistically, EF24 selectively kills SCs by inducing SC apoptosis in a reactive oxygen species (ROS) production independent manner but associated with an increase in the proteasome degradation of the Bcl-2 anti-apoptotic protein family proteins known to play an important role in protecting SCs from apoptosis. [32] We have previously shown that Alisertib (MLN8237), an Aurora A kinase inhibitor, potently and selectively kills HPV-positive cervical cancer cells. [33] Background: Boron neutron capture therapy (BNCT) selectively kills tumor cells while sparing adjacent normal cells. [34] The peptidyl-prolyl isomerase inhibitor Cyclosporine A (CsA) selectively kills EGFR+ or HER2+ breast cancer cells in vitro by activating caspase-dependent apoptotic pathways. [35] We show that appropriate linkage of the kis gene to a single, fully complementary, target site for an oncogenic human microRNA enables the construction of a synthetic toxin-antitoxin pair that selectively kills cancer cells overexpressing that particular microRNA. [36] If undesired DNA from the carrier integrates into the cell DNA, as occasionally occurs, the action of the suicide gene selectively kills the affected cells. [37] 457 A small-molecule inhibitor selectively kills mycobacteria by targeting a pathway that a countering enzyme makes vulnerable. [38] PLK1 inhibition selectively kills cancer cells because cancer cells utterly depend on the mitotic functions of PLK1 overexpression. [39] 77, which means it was toxic to cancer cells but safe for Vero cell lines, and its selectively kills cancer cells rather than Vero cell lines. [40] Korormicin is an antibiotic produced by some pseudoalteromonads which selectively kills Gram-negative bacteria that express the Na+-pumping NADH:quinone oxidoreductase (Na+-NQR. [41] We have previously shown that TPEN selectively kills colon cancer cells based on its ability to chelate copper, which is highly enriched in colon cancer cells. [42]重要的是，它在较高浓度下选择性地杀死衰老细胞，主要是通过增强活性氧 (ROS) 的产生和干扰线粒体膜电位，这些过程伴随着衰老细胞中 Bcl-2 家族促凋亡因子 Puma 和 Noxa 的上调。 [1] 咖啡酸对代谢过程的作用选择性地杀死癌症而不是正常细胞。 [2] pseudintermedius 在脓肿形成过程中选择性地杀死巨噬细胞，从而拮抗关键的宿主免疫细胞反应。 [3] 在此，我们显示 TQ 选择性地杀死 DLBCL 细胞，无论是细胞系还是对标准治疗具有抗性特征的原发性淋巴瘤细胞。 [4] 通过高通量小分子筛选，我们将抗生素 Novobiocin (NVB) 鉴定为一种特异性 POLθ 抑制剂，可在体外和体内选择性地杀死 HR 缺陷型肿瘤细胞。 [5] 结论：PNC-27 通过该肽与膜 H/MDM-2 的结合选择性地杀死结肠癌干细胞。 [6] 结果：IL2-R336A 融合蛋白选择性地杀死表达 IL-2 受体的免疫抑制性 Treg，而对该靶点呈阴性的细胞几乎没有影响。 [7] 抑制 PLK1 选择性地杀死癌细胞并上调存活癌细胞中 PD-L1 的表达，从而为 ARAC 以正反馈方式靶向递送提供机会。 [8] 冷大气等离子体 (CAP) 有望作为一种癌症特异性治疗剂，选择性地杀死基底样/TN 乳腺癌细胞。 [9] 我们证明，这种疗法不仅可以选择性地杀死肿瘤，还可以触发来自肿瘤的促免疫信号以吸引免疫细胞。 [10] 我们首次在体外显示，TCBZ 在 2–4 µg/mL 的最小抑制浓度 (MIC) 范围内选择性杀死对甲氧西林敏感和耐甲氧西林的金黄色葡萄球菌和假中间葡萄球菌，在 MIC 范围内选择性杀死耐万古霉素的肠球菌范围为 4–8 µg/mL。 [11] 意义声明：本研究描述了局部注射 senolytic 载药纳米粒子，该纳米粒子选择性地杀死梗塞心脏中的应激诱导的衰老细胞 (SISC)。 [12] 重要的是，它在较高浓度下选择性地杀死衰老细胞，主要是通过增强活性氧 (ROS) 的产生和干扰线粒体膜电位，这些过程伴随着衰老细胞中 Bcl-2 家族促凋亡因子 Puma 和 Noxa 的上调。 [13] 以前，我们发现 BCL2 抑制剂 venetoclax 在用抗 CD3/抗 CD28 重新激活后，可以选择性地杀死急性 HIV 感染的细胞并减少潜伏感染的 CD4 T 细胞中的 HIV DNA。 [14] Mdr2-/- 小鼠也接受了非瑟酮治疗，这是一种选择性杀死衰老细胞的类黄酮分子。 [15] 氧代（corrolato）铬（v）复合物选择性地杀死白血病细胞。 [16] 这种细菌通过分泌一种在不同阶段选择性地杀死寄生虫的脂肪酶，使蚊子能够抵抗人类寄生虫恶性疟原虫或啮齿动物寄生虫伯氏疟原虫的感染。 [17] nan [18] nan [19] nan [20] nan [21] nan [22] nan [23] nan [24] nan [25] nan [26] nan [27] nan [28] nan [29] nan [30] nan [31] nan [32] nan [33] nan [34] nan [35] nan [36] nan [37] nan [38] nan [39] nan [40] nan [41] nan [42]
27 Selectively Kills
Conclusion: PNC-27 selectively kills colon cancer stem cells by binding of this peptide to membrane H/MDM-2. [1] We concluded that mHDM2 represents a novel and unique therapeutic target, and targeting mHDM2 using PNC-27 selectively kills AML cells, including LSCs, with minimal off-target hematopoietic toxicity. [2]结论：PNC-27 通过该肽与膜 H/MDM-2 的结合选择性地杀死结肠癌干细胞。 [1] nan [2]
Inhibition Selectively Kills
Immunoproteasome inhibition selectively kills human monocytes. [1] PLK1 inhibition selectively kills cancer cells because cancer cells utterly depend on the mitotic functions of PLK1 overexpression. [2]selectively kills cancer
The action of Caffeic Acid on metabolic processes selectively kills cancer but not normal cells. [1] Inhibition of PLK1 selectively kills cancer cells and upregulates PD-L1 expression in surviving cancer cells thereby providing opportunity for ARAC targeted delivery in a positive feedback manner. [2] A cell permeable peptide harboring the L126-Y133 sequence inhibited PCNA function in cancer cells and selectively kills cancer cells and xenograft tumors. [3] We show that appropriate linkage of the kis gene to a single, fully complementary, target site for an oncogenic human microRNA enables the construction of a synthetic toxin-antitoxin pair that selectively kills cancer cells overexpressing that particular microRNA. [4] Recently, a new class of non-platinum-based halogenated molecules (called FMD compounds) was discovered that selectively kills cancer cells. [5] Using genetic and chemical approaches, we showed that hyperactivation of the protease selectively kills cancer cells, independently of p53 status, by selective degradation of its respiratory chain protein substrates and disrupts mitochondrial structure and function, while it does not affect non-malignant cells. [6] We show that appropriate linkage of the kis gene to a single, fully complementary, target site for an oncogenic human microRNA enables the construction of a synthetic toxin-antitoxin pair that selectively kills cancer cells overexpressing that particular microRNA. [7] PLK1 inhibition selectively kills cancer cells because cancer cells utterly depend on the mitotic functions of PLK1 overexpression. [8] 77, which means it was toxic to cancer cells but safe for Vero cell lines, and its selectively kills cancer cells rather than Vero cell lines. [9]咖啡酸对代谢过程的作用选择性地杀死癌症而不是正常细胞。 [1] 抑制 PLK1 选择性地杀死癌细胞并上调存活癌细胞中 PD-L1 的表达，从而为 ARAC 以正反馈方式靶向递送提供机会。 [2] nan [3] nan [4] nan [5] nan [6] nan [7] nan [8] nan [9]
selectively kills tumor
Background: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively kills tumor cells in cancer patients. [1] As AMPs are positively charged molecules that recognize negatively charged molecules exposed on the cell surface of pathogens during infection, Parvy et al hypothesized that the AMP selectively kills tumor cells while sparing normal cells by using a similar mechanism. [2] Background: Boron neutron capture therapy (BNCT) selectively kills tumor cells while sparing adjacent normal cells. [3]selectively kills senescent
Importantly, it selectively kills senescent cells upon application at higher concentrations, mainly by enhancing production of reactive oxygen species (ROS) and disturbing mitochondrial membrane potential, processes accompanied by upregulation of Bcl-2 family pro-apoptotic factors Puma and Noxa in senescent cells. [1] Importantly, it selectively kills senescent cells upon application at higher concentrations, mainly by enhancing production of reactive oxygen species (ROS) and disturbing mitochondrial membrane potential, processes accompanied by upregulation of Bcl-2 family pro-apoptotic factors Puma and Noxa in senescent cells. [2] Mdr2-/- mice were also treated with fisetin, a flavonoid molecule that selectively kills senescent cells. [3]重要的是，它在较高浓度下选择性地杀死衰老细胞，主要是通过增强活性氧 (ROS) 的产生和干扰线粒体膜电位，这些过程伴随着衰老细胞中 Bcl-2 家族促凋亡因子 Puma 和 Noxa 的上调。 [1] 重要的是，它在较高浓度下选择性地杀死衰老细胞，主要是通过增强活性氧 (ROS) 的产生和干扰线粒体膜电位，这些过程伴随着衰老细胞中 Bcl-2 家族促凋亡因子 Puma 和 Noxa 的上调。 [2] Mdr2-/- 小鼠也接受了非瑟酮治疗，这是一种选择性杀死衰老细胞的类黄酮分子。 [3]
selectively kills colon
Conclusion: PNC-27 selectively kills colon cancer stem cells by binding of this peptide to membrane H/MDM-2. [1] We have previously shown that TPEN selectively kills colon cancer cells based on its ability to chelate copper, which is highly enriched in colon cancer cells. [2]结论：PNC-27 通过该肽与膜 H/MDM-2 的结合选择性地杀死结肠癌干细胞。 [1] nan [2]