Scale Clinical(规模临床)研究综述Scale Clinical 规模临床 - Importantly, carbon quantum dots have been suggested to yield a lower chance of inducing bacterial resistance than antibiotics, making carbon quantum dots attractive for large scale clinical use.  Several large-scale clinical studies in different patient populations have shown that patients with advanced liver disease maintain a risk for developing HCC even when the original instigator, the virus, is eliminated by DAAs.  A large‐scale clinical validation is warranted in resource‐limited countries.  To provide further scientific evidence for the health-promoting effects of polyamines, large-scale clinical studies involving multiple groups are expected in the future.  However, a large‐scale clinical trial showed that some patients with IM still had negative plasma EBV DNA findings.  A further definitive large-scale clinical trial is necessary.  Finally, large-scale clinical and genetically informed studies, preferably linked with registry data and electronic health records, may clarify specific etiological mechanisms involved, leading to trials of interventions targeting these mechanisms.  This is a preliminary study which needs to be further confirmed by large-scale clinical studies.  Allopurinol, the first-line treatment, demonstrates low response rate (< 40%), defined as serum urate (sUA) lowering effect below 6 mg/dL, in multiple large-scale clinical trials.  In the absence of large-scale clinical trials, the management of women with VWD during pregnancy is guided by expert consensus guidelines.  This finding provides a basis for large-scale clinical trials with dexmedetomidine.  BACKGROUND Over the past 2 decades, a growing number of large-scale clinical trials have helped expand the toolkit for emergency management of acute ischemic stroke.  Preclinical studies provide support for an antiinflammatory role of albumin, but confirmatory large-scale clinical trials are lacking.  Colorectal cancer (CRC) is a leading cause of cancer-related death, and the prevalence of CRC in young adults is on the rise, making this a largescale clinical concern.  Conclusions The results of this study will provide the feasibility of a large-scale clinical trial to establish high-quality clinical evidence of CMT for COPD.  Increasing discovery of abnormal alterations in N-linked glycans associated with many diseases leads to greater demands for rapid and efficient N-glycosylation profiling in large-scale clinical samples.  The efficacy of IL17 inhibitor (IL17i) in inflammatory arthritis (IA) including ankylosing spondylitis (AS) and psoriatic arthritis (PsA) has been ascertained in largescale clinical trials, while safety, especially infections, should be further addressed and paid more attention to by clinicians in longterm administration.  Previous experience from the experimental use of Flamigel® in two large-scale clinical studies on affected skin has proven sufficiently positive for the addition of a new product in the Flamigel® family (now commercially available in the UK as Flamigel RT®, Flen Health UK).  However, further investigation is yet needed to fully explain the cellular mechanisms of action of GTCs on human health and to elucidate the effect of encapsulation on their bioefficacy using well-designed, systematic, long-term, and large-scale clinical interventions.  The purpose of this study was to develop an automated patient-specific and organ-based image quality (IQ) assessment tool for dual energy (DE) computed tomography (CT) images for large scale clinical analysis.  However, standardization of the test methods and large-scale clinical validation are necessary before these tests can be applied in a clinical setting.  To the best of our knowledge, no large-scale clinical trials designed to test and improve gait and balance kinematics in patients with severe COPD are presently underway.  Nevertheless, because of the small number of trials included in the present study, further large-scale clinical studies are warranted to support our findings.  The large-scale clinical trials carried out in recent years have demonstrated the beneficial effect of these compounds not only on glycemic control, but also on the progression of heart failure in patients with diabetes mellitus.  The approach was implemented in various algorithmic setups, and it was validated on data from a small-scale clinical trial with continuous glucose monitoring.  Ischemia detected using a very low-dose exercise-first MPI protocol in a large-scale clinical cohort and under real-life routine conditions is a highly significant predictor for the subsequent reporting of coronary stenosis, although this prediction is enhanced by other variables.  The repeated failures of large-scale clinical trials evaluating the efficacy of well-established cardioprotective therapies in HFpEF highlight the need for a paradigm shift in our approach to its treatment.  Such host–microbe interactions in the systemic circulation of patients with severe pneumonia warrant further large-scale clinical and mechanistic investigations.  In recent years, there has been a surge in the application of AI to research in cardiovascular medicine, which is largely driven by the availability of large-scale clinical and multi-omics datasets.  Finerenone, a second nonsteroidal MR blocker for which large-scale clinical trials have been completed [7, 8], showed a lower risk of CKD progression and cardiovascular events than placebo in patients with CKD and type 2 diabetes (Table 1).  Large-scale clinical studies can now be rationally designed to provide a bench-to-bedside translation of the multifactorial bacterial mechanisms within the host respiratory tract, to diminish the incidence and severity of viral infections and the concomitant complications.  Expect outcomes To our knowledge, this is the first large scale clinical trial to evaluate the impacts of TCM syndrome differentiation on the progression and therapeutic outcome of HF patients and explore the diagnostic value of TCM Tongue Diagnosis in HF patients.  In the next step, we plan to observe chronological changes, and have already started large-scale clinical trials in this regard.  In the near future, large-scale clinical trials will be initiated to further explore this issue.  Despite the emergence of promising therapeutic approaches in preclinical studies, the failure of large-scale clinical trials leaves clinicians without effective treatments for acute spinal cord injury (SCI).  Well-designed and large-scale clinical trials are needed to help define the role of aspirin as a protective pharmaceutical for UIAs.  These consensus recommendations for functional communication, swallowing, cough and related conditions set the stage nicely for largescale clinical trials aimed at rigorously testing the efficacy of the proposed strategies, as well as understanding clinical and neurobiological factors linked to individual differences in clinical outcomes.  A large-scale clinical cohort and single-cell RNA-seq technology were used to identify the molecular characteristics of inflamed or noninflamed tumors.  Combinations with other systemic or local treatments are perceived as the most promising opportunities in HCC and some are already under evaluation in large-scale clinical trials.  Our findings provide a rationale to investigate the use of statins among patients with COVID-19 in large scale clinical trials.  Currently, the lack of large-scale clinical studies limits our understanding of PACC.  Small-scale clinical studies performed in recent years have shown improvements in the major pathological remission rate after neoadjuvant therapy, suggesting that it will soon become an important part of NSCLC treatment.  Currently, there are no adequately powered large-scale clinical trials to evaluate the effectiveness and dissemination potential of behavioral pain management for adults with SCD.  Our overarching goal is to make the implementation of domain-specific testing more feasible for large-scale clinical trials on stroke recovery.  Large-scale clinical trials are needed to validate these claims.  Nevertheless, large-scale clinical trials and evaluation of long-term effects are necessary in further studies.  In the recent 10 years, high dose intravenous injection of vitamin C, the first line antioxidant of human, has received more and more attention in the field of critical care, its beneficial effect has been demonstrated by several small scale clinical trial and animal studies, but the effect of high dose vitamin C on sepsis in a larger trial seems warranted in further study.  Some evidence has been gathered in favor of its use, but data from large scale clinical trials are expected to give more insight into the matter .  In two 10 000-scale clinical trials, the vaccines were effective in 95% and 70.  Replication studies with more diverse samples and different criterion measures are still needed before large-scale clinical application of this scale. 
重要的是，碳量子点被认为比抗生素产生细菌耐药性的机会更低，这使得碳量子点对大规模临床应用具有吸引力。  在不同患者人群中进行的几项大规模临床研究表明，即使最初的煽动者病毒被 DAA 消除，晚期肝病患者仍存在发生 HCC 的风险。  在资源有限的国家需要进行大规模的临床验证。  为了为多胺的健康促进作用提供进一步的科学证据，预计未来将进行涉及多个群体的大规模临床研究。  然而，一项大规模临床试验表明，一些 IM 患者的血浆 EBV DNA 检测结果仍为阴性。  需要进一步确定的大规模临床试验。  最后，大规模临床和遗传信息研究，最好与登记数据和电子健康记录相关联，可以阐明所涉及的具体病因机制，从而针对这些机制进行干预试验。  这是一项初步研究，需要通过大规模临床研究进一步证实。  别嘌醇作为一线治疗药物，在多项大规模临床试验中显示出低反应率（< 40%），定义为血清尿酸（sUA）降低效果低于 6 mg/dL。  在缺乏大规模临床试验的情况下，妊娠期 VWD 女性的管理以专家共识指南为指导。  这一发现为右美托咪定的大规模临床试验提供了基础。  背景 在过去的 20 年中，越来越多的大规模临床试验帮助扩展了急性缺血性卒中应急管理的工具包。  临床前研究为白蛋白的抗炎作用提供了支持，但缺乏确证性的大规模临床试验。  结直肠癌 (CRC) 是癌症相关死亡的主要原因，并且在年轻人中 CRC 的患病率正在上升，这使其成为一个大规模的临床问题。  结论 本研究结果将为建立 CMT 治疗 COPD 的高质量临床证据提供大规模临床试验的可行性。  越来越多的发现与许多疾病相关的 N-连接聚糖异常改变导致对大规模临床样本中快速有效的 N-糖基化分析的更大需求。  IL17抑制剂（IL17i）对包括强直性脊柱炎（AS）和银屑病关节炎（PsA）在内的炎症性关节炎（IA）的疗效已在大规模临床试验中得到证实，而安全性，尤其是感染，应进一步解决和重视。临床医生长期用药。  Flamigel® 先前在受影响皮肤的两项大规模临床研究中的实验性使用经验已证明，对于在 Flamigel® 系列中添加新产品（现已在英国以 Flamigel RT® 的形式在英国市售，Flen Health UK 有足够的积极性） ）。  然而，还需要进一步的研究来充分解释 GTCs 对人类健康的细胞作用机制，并通过精心设计、系统、长期和大规模的临床干预来阐明封装对其生物功效的影响。  本研究的目的是为用于大规模临床分析的双能 (DE) 计算机断层扫描 (CT) 图像开发一种自动的患者特异性和基于器官的图像质量 (IQ) 评估工具。  然而，在将这些测试应用于临床环境之前，测试方法的标准化和大规模的临床验证是必要的。  据我们所知，目前还没有大规模临床试验旨在测试和改善重度 COPD 患者的步态和平衡运动学。  然而，由于本研究中包含的试验数量较少，因此需要进一步的大规模临床研究来支持我们的研究结果。  近年来进行的大规模临床试验表明，这些化合物不仅对血糖控制有益，而且对糖尿病患者心力衰竭的进展也有益处。  该方法在各种算法设置中实施，并通过连续血糖监测的小规模临床试验数据进行了验证。  在大规模临床队列和现实生活常规条件下，使用极低剂量运动优先 MPI 方案检测到的缺血是随后报告冠状动脉狭窄的非常重要的预测因子，尽管其他变量增强了这种预测。  评估成熟的心脏保护疗法对 HFpEF 疗效的大规模临床试验屡次失败，这凸显了我们治疗方法的范式转变的必要性。  重症肺炎患者体循环中的这种宿主-微生物相互作用需要进一步的大规模临床和机制研究。  近年来，人工智能在心血管医学研究中的应用激增，这在很大程度上是由大规模临床和多组学数据集的可用性推动的。  Finerenone 是另一种已完成大规模临床试验的非甾体 MR 阻滞剂 [7, 8]，在 CKD 和 2 型糖尿病患者中，CKD 进展和心血管事件的风险低于安慰剂（表 1）。  现在可以合理地设计大规模临床研究，以提供宿主呼吸道内多因素细菌机制的从实验室到床边的转化，以减少病毒感染和伴随并发症的发生率和严重程度。  预期结果 据我们所知，这是首个评估中医辨证论治对心衰患者病情进展和疗效影响的大规模临床试验，探讨中医舌诊对心衰患者的诊断价值。  下一步，我们计划观察时间的变化，并且已经开始了这方面的大规模临床试验。  在不久的将来，将启动大规模的临床试验来进一步探索这个问题。  尽管在临床前研究中出现了有希望的治疗方法，但大规模临床试验的失败使临床医生无法有效治疗急性脊髓损伤 (SCI)。  需要精心设计的大规模临床试验来帮助确定阿司匹林作为 UIA 保护药物的作用。  这些关于功能性交流、吞咽、咳嗽和相关疾病的共识建议为大规模临床试验奠定了良好的基础，旨在严格测试所提出策略的有效性，并了解与临床结果中个体差异相关的临床和神经生物学因素。  使用大规模临床队列和单细胞 RNA-seq 技术来识别发炎或非发炎肿瘤的分子特征。  与其他全身或局部治疗的组合被认为是 HCC 最有希望的机会，其中一些已经在大规模临床试验中进行评估。  我们的研究结果为在大规模临床试验中调查 COVID-19 患者中他汀类药物的使用提供了依据。  目前，缺乏大规模的临床研究限制了我们对 PACC 的理解。  近年来进行的小规模临床研究表明，新辅助治疗后主要病理缓解率有所改善，表明其将很快成为NSCLC治疗的重要组成部分。  目前，没有足够强大的大规模临床试验来评估行为疼痛管理对 SCD 成人的有效性和传播潜力。  我们的首要目标是使特定领域测试的实施对于中风恢复的大规模临床试验更加可行。  需要大规模的临床试验来验证这些说法。  然而，在进一步的研究中，还需要进行大规模的临床试验和长期效果评估。  近10年来，大剂量静脉注射维生素C作为人体的一线抗氧化剂，在重症监护领域越来越受到重视，多项小规模临床试验和动物研究证实了其有益效果，但在更大的试验中，高剂量维生素 C 对败血症的影响似乎需要进一步研究。  已经收集了一些支持其使用的证据，但预计来自大规模临床试验的数据将对此事提供更深入的了解。  在两项 10 000 人规模的临床试验中，疫苗在 95% 和 70 人中有效。  在该量表的大规模临床应用之前，仍需要对更多样化的样本和不同的标准测量进行复制研究。  Importantly, carbon quantum dots have been suggested to yield a lower chance of inducing bacterial resistance than antibiotics, making carbon quantum dots attractive for large scale clinical use.  The purpose of this study was to develop an automated patient-specific and organ-based image quality (IQ) assessment tool for dual energy (DE) computed tomography (CT) images for large scale clinical analysis.  Expect outcomes To our knowledge, this is the first large scale clinical trial to evaluate the impacts of TCM syndrome differentiation on the progression and therapeutic outcome of HF patients and explore the diagnostic value of TCM Tongue Diagnosis in HF patients.  Our findings provide a rationale to investigate the use of statins among patients with COVID-19 in large scale clinical trials.  Some evidence has been gathered in favor of its use, but data from large scale clinical trials are expected to give more insight into the matter .  However, pre-clinical and clinical trials are largely required to confirm its safety and efficacy before large scale clinical application.  However, the evidence is inadequate and future large scale clinical are required.  Results In this paper, we present VINYL, a highly accurate and fully automated system for the functional annotation and prioritization of genetic variants in large scale clinical studies.  Large scale clinical trials are needed to further find out about the different strains, formulations, prefer- red delivery method and doses of marijuana required for effective treatment.  Our strategy demonstrates an easy-to-use proteomic analysis on immune cells with the potential to discover novel subtype-specific protein biomarkers from limited clinical samples in future large scale clinical studies.  This is the first case of high-grade hemangiopericytoma successfully managed with these newly approve tyrosine kinase inhibitors, a large scale clinical research on the targeted therapy of this tumor would be necessary to further understanding the pharmaceutical mechanisms of Anlotinib Hydrochloride on the tumor suppression of CNS hemangiopericytoma.  While large scale clinical trials are lacking, current clinical evidence has demonstrated significant efficacy in achieving durable PVI without ablation related adverse events.  METABOLyx represents the first large scale clinical trial of an immunomodulatory biologic in combination with a standardized lifestyle intervention.  CONCLUSIONS DLA is an efficient method to enrich CTCs, although the modest success rate of culturing CTCs precludes large scale clinical application.  Further large scale clinical trials are required to verify potential anti-cancer effects of n-3 fatty acids.  This model will allow precise dosing recommendations without the need of large scale clinical trials.  LIMITATIONS Further large scale clinical studies are needed to assess the most effective management of twelfth rib syndrome.  Nevertheless, due to their superb safety profiles, palm oil tocotrienols are still considered ideal candidates for future large scale clinical trials to prove their efficacy to treat or prevent cancers in humans.  While JAK inhibitors have not been shown to significantly increase the risk of non-melanoma skin cancer (NMSC) in large scale clinical trials, NMSC is one of the most concerning possible adverse events, and there have been several reported cases of aggressive squamous cell carcinomas, especially in our already immunosuppressed patient populations.  Based on the results from multiple large scale clinical outcome trials, this class of LDL-C lowering agents has been recommended as appropriate second-line agents, or as an alternative therapy in cases of significant statin intolerance, for patients with established ASCVD and suboptimal LDL levels.  Alternative methods, specifically magnetic resonance imaging, provide high cost and practical challenges in large scale clinical application.  Once refined, large scale clinical trials to thoroughly interrogate pharmacotherapy alone and in combination with other strategies will be required.  More recently, PCSK9 monoclonal antibodies have been reported to reduce cardiovascular event rates in large scale clinical trials. 
重要的是，碳量子点被认为比抗生素产生细菌耐药性的机会更低，这使得碳量子点对大规模临床应用具有吸引力。  本研究的目的是为用于大规模临床分析的双能 (DE) 计算机断层扫描 (CT) 图像开发一种自动的患者特异性和基于器官的图像质量 (IQ) 评估工具。  预期结果 据我们所知，这是首个评估中医辨证论治对心衰患者病情进展和疗效影响的大规模临床试验，探讨中医舌诊对心衰患者的诊断价值。  我们的研究结果为在大规模临床试验中调查 COVID-19 患者中他汀类药物的使用提供了依据。  已经收集了一些支持其使用的证据，但预计来自大规模临床试验的数据将对此事提供更深入的了解。  然而，在大规模临床应用之前，很大程度上需要进行临床前和临床试验以确认其安全性和有效性。  nan  nan  nan  nan  这是首例用这些新批准的酪氨酸激酶抑制剂成功治疗的高级别血管外皮细胞瘤，需要对该肿瘤的靶向治疗进行大规模临床研究，以进一步了解盐酸安罗替尼抑制中枢神经系统肿瘤的药物机制血管外皮细胞瘤。  nan  nan  nan  nan  nan  nan  nan  nan  根据多项大规模临床结果试验的结果，已推荐此类降低 LDL-C 的药物作为合适的二线药物，或作为他汀类药物严重不耐受的替代疗法，用于已确诊的 ASCVD 和次优 LDL 患者水平。  nan  nan  nan  This study may contribute to a better understanding of the differences in effectiveness of OLP topical treatments and guide future larger scale clinical trials.  Future larger scale clinical trials and prospective studies are needed to clarify the role of KDs in the treatment of HGG.  Larger scale clinical studies are needed to accumulate further data and make clinical comparisons with the ICC ESU.  This pilot study is intended to support future larger scale clinical trials investigating this target.  Future larger scale clinical studies are warranted to more systematically investigate the effects of commensal microbes and patient risk factors on the colonization and transmission of C.  These neurophysiological changes associated with the positive effects of post-stroke MST on motor outcomes delineate a path for a larger scale clinical trial.  A larger scale clinical trial with follow-up at extended time points is needed to more fully examine the efficacy of this novel programme.  Retinal microvasculature changes worth further investigation in larger scale clinical trials. 
这项研究可能有助于更好地了解 OLP 局部治疗的有效性差异，并指导未来更大规模的临床试验。  需要未来更大规模的临床试验和前瞻性研究来阐明 KD 在 HGG 治疗中的作用。  nan  nan  nan  nan  nan  nan  In the recent 10 years, high dose intravenous injection of vitamin C, the first line antioxidant of human, has received more and more attention in the field of critical care, its beneficial effect has been demonstrated by several small scale clinical trial and animal studies, but the effect of high dose vitamin C on sepsis in a larger trial seems warranted in further study.  The purpose of this small scale clinical study was to validate the usability of MEMS accelerometer based bedsensor for detection of AFib. 
近10年来，大剂量静脉注射维生素C作为人体的一线抗氧化剂，在重症监护领域越来越受到重视，多项小规模临床试验和动物研究证实了其有益效果，但在更大的试验中，高剂量维生素 C 对败血症的影响似乎需要进一步研究。  nan  However, a large‐scale clinical trial showed that some patients with IM still had negative plasma EBV DNA findings.  A further definitive large-scale clinical trial is necessary.  Allopurinol, the first-line treatment, demonstrates low response rate (< 40%), defined as serum urate (sUA) lowering effect below 6 mg/dL, in multiple large-scale clinical trials.  In the absence of large-scale clinical trials, the management of women with VWD during pregnancy is guided by expert consensus guidelines.  This finding provides a basis for large-scale clinical trials with dexmedetomidine.  BACKGROUND Over the past 2 decades, a growing number of large-scale clinical trials have helped expand the toolkit for emergency management of acute ischemic stroke.  Preclinical studies provide support for an antiinflammatory role of albumin, but confirmatory large-scale clinical trials are lacking.