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10.21203/RS.3.RS-721043/V1

Remarkably, we characterized the bat/Cambodia virus as a recombinant SARS-CoV-2/RatG13 with the S1-NTD of bat-SARS-like viruses; while only bat/RatG13 with Type-I-S1-NTD established a huge pandemic outbreak.

值得注意的是，我们将蝙蝠/柬埔寨病毒定性为具有蝙蝠-SARS 样病毒 S1-NTD 的重组 SARS-CoV-2/RatG13；而只有具有 Type-I-S1-NTD 的 bat/RatG13 引起了大规模的流行病爆发。

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10.1038/s41422-021-00556-z

Sarbecoviruses (lineage B of genus Betacoronavirus) have caused two major outbreaks during the past two decades (SARS-CoV in 2003, and SARS-CoV-2 from 2019), and more SARS-like viruses are continuously found from nature reservoirs.

Sarbecoviruses（Betacoronavirus 属的 B 系）在过去 20 年中引起了两次重大爆发（2003 年的 SARS-CoV 和 2019 年的 SARS-CoV-2），并且在自然宿主中不断发现更多类似 SARS 的病毒。

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10.1038/s41392-021-00661-w

In a recent article published in Science, Rappazzo and co-authors engineered a human monoclonal antibody to bind and neutralize a broad range of SARS-like viruses.

在最近发表在《科学》杂志上的一篇文章中，Rappazzo 和合著者设计了一种人类单克隆抗体，以结合和中和广泛的 SARS 样病毒。

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10.1101/2021.03.11.434872

Sentence Chimerized RBD, NTD, and S2 spike mRNA-LNPs protect mice against epidemic, zoonotic, and pandemic SARS-like viruses.

Sentence Chimerized RBD、NTD 和 S2 刺突 mRNA-LNP 可保护小鼠免受流行病、人畜共患病和大流行性 SARS 样病毒的侵害。

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10.1126/science.abi4506

A broad defense against SARS-like viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus that has emerged as a serious human pathogen in the past 20 years.

对 SARS 样病毒的广泛防御严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 是过去 20 年中作为严重人类病原体出现的第三种冠状病毒。

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Sars Like Viruses 非典病毒

Sars Like Viruses 非典病毒

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Jul 05, 2022

Sars Like Viruses(非典病毒)研究综述

Sars Like Viruses 非典病毒 - Remarkably, we characterized the bat/Cambodia virus as a recombinant SARS-CoV-2/RatG13 with the S1-NTD of bat-SARS-like viruses; while only bat/RatG13 with Type-I-S1-NTD established a huge pandemic outbreak. ^[1] Sarbecoviruses (lineage B of genus Betacoronavirus) have caused two major outbreaks during the past two decades (SARS-CoV in 2003, and SARS-CoV-2 from 2019), and more SARS-like viruses are continuously found from nature reservoirs. ^[2] In a recent article published in Science, Rappazzo and co-authors engineered a human monoclonal antibody to bind and neutralize a broad range of SARS-like viruses. ^[3] Sentence Chimerized RBD, NTD, and S2 spike mRNA-LNPs protect mice against epidemic, zoonotic, and pandemic SARS-like viruses. ^[4] A broad defense against SARS-like viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus that has emerged as a serious human pathogen in the past 20 years. ^[5]
值得注意的是，我们将蝙蝠/柬埔寨病毒定性为具有蝙蝠-SARS 样病毒 S1-NTD 的重组 SARS-CoV-2/RatG13；而只有具有 Type-I-S1-NTD 的 bat/RatG13 引起了大规模的流行病爆发。 ^[1] Sarbecoviruses（Betacoronavirus 属的 B 系）在过去 20 年中引起了两次重大爆发（2003 年的 SARS-CoV 和 2019 年的 SARS-CoV-2），并且在自然宿主中不断发现更多类似 SARS 的病毒。 ^[2] 在最近发表在《科学》杂志上的一篇文章中，Rappazzo 和合著者设计了一种人类单克隆抗体，以结合和中和广泛的 SARS 样病毒。 ^[3] Sentence Chimerized RBD、NTD 和 S2 刺突 mRNA-LNP 可保护小鼠免受流行病、人畜共患病和大流行性 SARS 样病毒的侵害。 ^[4] 对 SARS 样病毒的广泛防御严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 是过去 20 年中作为严重人类病原体出现的第三种冠状病毒。 ^[5]