Salt Sensitive Hypertensive(盐敏感性高血压)研究综述
Salt Sensitive Hypertensive 盐敏感性高血压 - From Guyton’s natriuretic curve, we can infer that salt-sensitive hypertensive patients who consume too much salt do not excrete salt during the daytime and are forced to excrete salt at night, resulting in increased urine production and nocturia. [1] In conclusion, in salt-sensitive hypertensive patients plasma MBG concentration correlates with 24-h diastolic blood pressure and dietary sodium restriction reduces plasma MBG levels. [2] A close association exists between low DNA methylation at CEBP-binding sites and increased AGT expression in salt-sensitive hypertensive rats. [3] Given the important role of the brain-heart-kidney axis in blood pressure control, we hypothesized that QSYQ may contribute to blood pressure regulation and kidney protection in Dahl salt-sensitive hypertensive rats. [4] Objective — To investigate the effects of angiotensin 1-7 (Ang1-7) on plasma membrane ATPase isoform 1 (PMCA1) in salt-sensitive hypertensive rats. [5] Chronopharmacotherapy comprises an important approach to control arterial hypertension through personalised correction of blood pressure but requires a further proof of efficacy in salt-sensitive hypertensive patients. [6]从Guyton的利尿钠曲线可以推断，盐分敏感型高血压患者吃盐过多，白天不排盐，晚上被迫排盐，导致尿量增多，夜尿增多。 [1] 总之，在盐敏感性高血压患者中，血浆 MBG 浓度与 24 小时舒张压相关，并且饮食钠限制降低了血浆 MBG 水平。 [2] CEBP 结合位点的低 DNA 甲基化与盐敏感性高血压大鼠中 AGT 表达增加之间存在密切关联。 [3] 鉴于脑-心-肾轴在血压控制中的重要作用，我们假设 QSYQ 可能有助于 Dahl 盐敏感性高血压大鼠的血压调节和肾脏保护。 [4] 目的——研究血管紧张素 1-7 (Ang1-7) 对盐敏感性高血压大鼠质膜 ATPase 异构体 1 (PMCA1) 的影响。 [5] 计时药物疗法是通过个体化矫正血压来控制动脉高血压的重要方法，但需要进一步证明对盐敏感的高血压患者的疗效。 [6]