Retinoic Acid Induced(维甲酸诱导)研究综述
Retinoic Acid Induced 维甲酸诱导 - Further, the combined effects of loss modulus and retinoic acid-induced chemical stimulation on neuronal differentiation were investigated. [1] Our findings suggest JADE2 as a novel myeloid player involved in retinoic acid-induced differentiation. [2] The effects of WPH on osteoporosis were evaluated using a model of retinoic acid-induced osteoporosis rat. [3] In this review, the effects of PRRs from the Toll-like (TLRs), the retinoic acid-induced gene I (RIG-I)-like receptors (RLRs) and the NOD-like (NLRs) families, and the activation of these signaling pathways in regulating the production of ROS and/or oxidative stress are summarized. [4] We investigated the effect of exogenous glycosaminoglycans with well-defined structures on the all-trans-retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells, which is an ideal model culture system for studying neural differentiation. [5] Using the mouse P19 embryonal carcinoma cell model, Suppressor of Fused (SUFU), a negative regulator of the Hedgehog pathway, was investigated during retinoic acid-induced neural differentiation. [6] CPI-455 treatment or KDM5A knockout could greatly sensitize NB4 cells to all-trans retinoic acid-induced differentiation. [7] Re-expression of α-N-catenin enhanced the sensitivity to retinoic acid-induced cell growth arrest and downregulated key cell survival pathways in both cell lines. [8] Furthermore, we demonstrated that retinoic acid-induced protein 14 (RAI14) is a target of miR-34b via TargetScan and immunofluorescence assays. [9] Results Compared with the virus infection group, the IFN-β pretreatment virus infection group had an upregulated level of pro-inflammatory cytokine expression, which was inhibited by isorhamnetin significantly via the retinoic acid-induced gene I (RIG-I)/c-Jun N-terminal kinase (JNK) signaling pathway. [10] Our mechanistic studies indicated that m6A of HIV-1 RNA escaped retinoic acid-induced gene I (RIG-I)-mediated RNA sensing and activation of the transcription factors IRF3 and IRF7 that drive IFN-I gene expression. [11] Regions that change their activity upon retinoic acid-induced differentiation are more prevalent at distal intergenic regions when compared to constitutively active enhancers. [12] Retinoic acid-induced 2 (RAI2) has been shown to be a putative suppressor of the early hematogenous dissemination of tumor cells to the bone marrow in breast cancer. [13] Moreover, EC19 reduced cellular metastasis in a transwell invasion assay due to overexpression of E-cadherin, retinoic acid-induced 2 (RAI2) and Werner (WRN) genes. [14] However, under retinoic acid-induced differentiation, the accumulation of autophagosomes and lysosomes is impaired in p53 KO mESCs, indicating a critical role of p53 in the regulation of autophagy upon differentiation. [15] FOXC1 is up-regulated in retinoic acid-induced differentiation of F9 Embryonal Carcinoma (EC) cells; furthermore, FOXC1 specifically inhibits the core pluripotency factor Nanog by binding to the proximal promoter. [16] We show here that expression of the DEAD boxcontaining RNA helicases DDX5 and DDX17 is abundant throughout retinoic acid-induced neural differentiation of the human pluripotent stem cell (hPSC) line NTERA2, and is mostly localized within the nucleus. [17] Exposure to RF-EMF remarkably decreased the total length of neurite and the number of branch points in neural stem cells-derived neurons and retinoic acid-induced Neuro-2A cells. [18] Additionally, upregulated transcriptions of spermatogenic differentiation marker C-KIT and meiotic marker SYCP3 were detected in these cells after retinoic acid-induced differentiation. [19] Photographs of the mice's skin, biochemical analysis of the pro-inflammatory cytokines in the skin as well as histopathological examination, depicted that the optimized formulation promoted an obvious alleviation of the all-trans retinoic acid-induced photosensitivity, which was further potentiated by the addition of 6% titanium dioxide, compared to the marketed product. [20] From the results, it can be postulated that retinoic acid-induced stimulation of ovarian maturation at least in part mediates ecdysteroids in the mud crabs. [21] In this study, INCENP was highly expressed by NB cells and its expression decreased following retinoic acid-induced NB differentiation. [22] The objective of this study was to determine whether the hyaluronic acid (HA) concentration in amniotic fluid (AF) in the retinoic acid-induced model of MMC is different from that in normal controls and whether these differences could have an impact on the viscosity of AF. [23] As a proof-of-principle that a gene product with altered properties can be produced by these fusions, we characterized the ZNF451-BAG2 fusion which generates a truncated BAG2-protein capable of inhibiting retinoic acid-induced differentiation. [24] When GC hydrogel is applied prenatally to retinoic acid-induced fetal MMC in the rat model, without suture or glue, epidermal ingrowth and neovascularization were significantly increased by hydrogels, compared to the nontreatment group. [25] DESIGN AND METHODS The integrin α4β7 blockade by VDZ was evaluated on human primary memory CD4 T (MEMT) cells and retinoic acid-induced gut-homing α4β7MEMT cells (α4β7MEMT) in vitro. [26] Besides that, the cellular morphology and expression of differentiation markers were investigated to determine the effect of rhein on retinoic acid-induced neuronal cell differentiation. [27] In the present study, we identified the retinoic acid-induced gene I (RIG-I) like receptors (RLRs)/mitochondrial antiviral signaling (MAVS) pathway as a target of SWCNT-induced oxidative stress in small airway epithelial cells (SAEC) that contribute to significantly enhanced influenza viral titers. [28] Expression of the retinoic acid-induced protein 3 (RAI3) has been suggested to predict clinical outcome in a variety of malignancies. [29] METHODS In vivo studies were conducted in retinoic acid-induced SB defects in fetuses of Sprague-Dawley rats. [30] Retinoic acid-induced 14 (RAI14) is involved in the development of different tumor types, however, its expression and biological function in breast cancer are yet unknown. [31] Retinoic acid-induced activation of retinoic acid receptor response element (RARE)-tk-luciferase is dependent on exogenous expression of retinoic acid receptor alpha (RARa)/RXRa heterodimer in MDA-MB 231 but not in MCF7 and KAIMRC1 cell lines. [32] This process required RARα, a nuclear retinoic acid receptor that doubles as a cytoplasmic retinoic acid-induced postsynaptic regulator of protein synthesis. [33]此外，还研究了损耗模量和视黄酸诱导的化学刺激对神经元分化的综合影响。 [1] 我们的研究结果表明，JADE2 是一种参与视黄酸诱导分化的新型髓系细胞因子。 [2] 使用维甲酸诱导的骨质疏松大鼠模型评估 WPH 对骨质疏松症的影响。 [3] 在这篇综述中，来自 Toll 样 (TLRs)、维甲酸诱导基因 I (RIG-I) 样受体 (RLRs) 和 NOD 样 (NLRs) 家族的 PRR 的影响，以及这些家族的激活总结了调节 ROS 和/或氧化应激产生的信号通路。 [4] 我们研究了具有明确结构的外源性糖胺聚糖对全反式维甲酸诱导的 P19 胚胎癌细胞神经分化的影响，这是研究神经分化的理想模型培养系统。 [5] 使用小鼠 P19 胚胎癌细胞模型，在视黄酸诱导的神经分化过程中研究了 Hedgehog 通路的负调节因子 Fused 抑制子 (SUFU)。 [6] CPI-455 处理或 KDM5A 敲除可以极大地使 NB4 细胞对全反式维甲酸诱导的分化敏感。 [7] α-N-连环蛋白的重新表达增强了对视黄酸诱导的细胞生长停滞的敏感性并下调了两种细胞系中的关键细胞存活途径。 [8] 此外，我们通过 TargetScan 和免疫荧光测定证明视黄酸诱导的蛋白 14 (RAI14) 是 miR-34b 的靶标。 [9] 结果 与病毒感染组相比，IFN-β预处理病毒感染组促炎细胞因子表达水平上调，异鼠李素通过视黄酸诱导基因I（RIG-I）/c-Jun N显着抑制促炎细胞因子表达。 -末端激酶（JNK）信号通路。 [10] 我们的机制研究表明，HIV-1 RNA 的 m6A 逃逸了视黄酸诱导的基因 I (RIG-I) 介导的 RNA 传感和驱动 IFN-I 基因表达的转录因子 IRF3 和 IRF7 的激活。 [11] 与组成型活性增强剂相比，在视黄酸诱导分化时改变其活性的区域在远端基因间区域更为普遍。 [12] 维甲酸诱导的 2 (RAI2) 已被证明是乳腺癌中肿瘤细胞向骨髓的早期血行播散的推定抑制因子。 [13] 此外，由于 E-钙粘蛋白、视黄酸诱导的 2 (RAI2) 和 Werner (WRN) 基因的过表达，EC19 在 transwell 侵袭试验中减少了细胞转移。 [14] 然而，在视黄酸诱导的分化下，p53 KO mESCs 中自噬体和溶酶体的积累受损，表明 p53 在分化时自噬调节中的关键作用。 [15] FOXC1 在视黄酸诱导的 F9 胚胎癌细胞 (EC) 细胞分化中上调；此外，FOXC1 通过与近端启动子结合，特异性抑制核心多能因子 Nanog。 [16] 我们在这里展示了含有 RNA 解旋酶 DDX5 和 DDX17 的 DEAD box 的表达在整个维甲酸诱导的人类多能干细胞 (hPSC) 系 NTERA2 的神经分化中是丰富的，并且主要位于细胞核内。 [17] 暴露于 RF-EMF 显着降低了神经干细胞衍生的神经元和视黄酸诱导的 Neuro-2A 细胞中神经突的总长度和分支点的数量。 [18] 此外，在视黄酸诱导分化后，在这些细胞中检测到生精分化标志物 C-KIT 和减数分裂标志物 SYCP3 的上调转录。 [19] nan [20] nan [21] nan [22] nan [23] nan [24] nan [25] nan [26] nan [27] nan [28] nan [29] nan [30] nan [31] nan [32] nan [33]