Regulating P27kip1(调节 P27kip1)研究综述
Regulating P27kip1 调节 P27kip1 - Therefore, RCC1 could up‐regulate the expression level of PD‐L1 by regulating p27kip1/CDK4 pathway and decrease the resistance to ICIs. [1] Furthermore, western blot analysis demonstrated that the effects of ZNF692 were mediated by upregulating cyclin D1, cyclin-dependent kinase 2 (CDK2) and matrix metalloproteinase-9 (MMP-9) and by downregulating p27Kip1 through the phosphoinositide 3-kinase/AKT signaling pathway. [2]因此，RCC1可通过调节p27kip1/CDK4通路上调PD-L1的表达水平，降低对ICIs的耐药性。 [1] 此外，蛋白质印迹分析表明，ZNF692 的作用是通过上调细胞周期蛋白 D1、细胞周期蛋白依赖性激酶 2 (CDK2) 和基质金属蛋白酶 9 (MMP-9) 以及通过磷酸肌醇 3-激酶/AKT 信号通路下调 p27Kip1 来介导的. [2]
regulating p27kip1 expression 调节 P27kip1 表达
Our study not only identified miRNA‐221 as a pivotal factor conferring the acquired resistance of HER2‐positive breast cancer cells to lapatinib through negatively regulating p27kip1 expression, but also suggested Src inhibition as a potential strategy to overcome lapatinib resistance. [1] Chromatin immunoprecipitation analysis revealed that GATA3 directly binds to p27kip1 promoter and could maintain the quiescent state of cochlear SCs by regulating p27kip1 expression. [2]我们的研究不仅将 miRNA-221 确定为通过负调节 p27kip1 表达使 HER2 阳性乳腺癌细胞对拉帕替尼产生获得性耐药的关键因素，而且还表明 Src 抑制是克服拉帕替尼耐药的潜在策略。 [1] 染色质免疫沉淀分析显示，GATA3 直接与 p27kip1 启动子结合，可以通过调节 p27kip1 的表达来维持耳蜗 SCs 的静止状态。 [2]