Reduced Sensitivity(降低灵敏度)研究综述
Reduced Sensitivity 降低灵敏度 - Notably, selective knockout of the fer gene without affecting FerT expression reduced sensitivity to metformin and hypoxia seen in SW∆Fer/FerT cells. [1] As with diamide insecticides, the G4946E mutation confers greatly reduced sensitivity to pyrrole-2-carboxamides. [2] A number of factors have been suggested to contribute to fentanyl's lethality, including rapid onset of action, in vivo potency, ligand bias, induction of muscle rigidity and reduced sensitivity to reversal by naloxone. [3] Consistent with reduced sensitivity, ZmFACS expression was significantly lower in Mo17 as compared to B73. [4] The large differences observed between the OMI and MAX-DOAS VCDs are attributed to a reduced sensitivity of the satellite product near the surface and the large aerosol loading typically present within the mixed layer of the MCMA. [5] Moreover, the selection of parasites resistant to SQ109 implicates the druggable V-type H + -ATPase for the reduced sensitivity. [6] Among gram-negative bacteria, the most frequently isolated pathogen that causes eye infections is Pseudomonas aeruginosa, which is characterized by reduced sensitivity to antibiotics and disinfectants. [7] Paternal nicotine exposure reduced sensitivity to nicotine-induced hypothermia in males, altered nicotine metabolite concentrations in males and females, and reduced serum basal corticosterone levels in females. [8] Dithianon is a multi-site fungicide and has never been object of suspects and reports of reduced sensitivity and activity. [9] As a result, only in A-like-mutated cells we detected HOXA5, HOXA10, and HOXB5 hyper-expression and p14ARF/p21/p53 pathway deregulation, leading to reduced sensitivity to the treatment with either chemotherapy or Venetoclax, as compared to non-A-like cells. [10] Comparing to nasopharyngeal swab as the standard sample type accepted for diagnosing COVID-19,3 some studies reported saliva sample as an non-invasive specimen with good diagnostic performance,4,5 while others were either having conflicting results6 or had cautioned the potential of a reduced sensitivity when used in outpatient setting with a low disease prevalence. [11] This leads to phosphorylation and degradation of HER2 in these cells, resulting in the loss of or reduced sensitivity to T-DM1. [12] However, long-term treatment with sorafenib often results in reduced sensitivity of tumor cells to the drug, leading to acquired resistance. [13] Furthermore, simulated assays with a 3-fold or 10-fold reduced sensitivity would both appear to be >95% sensitive early in the pandemic, but sensitivity would fall to 85. [14] Therefore, SA/HC/SiO2 composite films could represent a simple, economical and sustainable alternative for packaging material with reduced sensitivity to water vapor. [15] It may have a future potential to target GH/PRL sensitivity in cases where conventional hormone treatment fails because of reduced sensitivity. [16] Testing for SARS-CoV-2, using face mask filters and nasopharyngeal swabs collected from hospitalized COVID-19-patients, showed that filter samples offered reduced sensitivity (8. [17] A comparative study between the SCDAE and a stacked convolutional autoencoder (SCAE) with different corruption levels showed that the SCDAE exhibited reduced sensitivity to stochastic disturbances with different corruption proportions, and had an enhanced ability to recognize geochemical anomalies varying in a reasonable range. [18] At the same time, it results in a much-reduced sensitivity to drifts increases the stability and reliability of the breadboard. [19] Mutants had a reduced sensitivity to auxin-mediated callus formation and inhibition of root elongation, and phenylboronic acid (PBA)-mediated inhibition of vein formation. [20] The biofilm-forming bacterium however, evolved a reduced sensitivity to the nanoparticle. [21] We conclude that malaria surveillance depending solely on RDTs needs well-integrated quality control procedures assessing the extend and impact of reduced sensitivity and specificity of RDTs on malaria control programs. [22] This paper presents a GaN HEMT outphasing power amplifier (PA), based on a class-E/ F2 topology with reduced sensitivity to variable resistive load operation, designed to provide output power control over an extended range with high efficiency. [23] Breath-hold divers (BHD) enduring apnea for more than 4 min are characterized by resistance to release of reactive oxygen species, reduced sensitivity to hypoxia, and low mitochondrial oxygen consumption in their skeletal muscles similar to northern elephant seals. [24] The response to sorafenib varies among hepatocellular carcinoma patients and many of the responders suffer from reduced sensitivity after long‐term treatment. [25] While we observed a sensitivity of roughly 77% in freeze-thawed matrices of close to ideal quality, our approach to simulate field conditions in direct carcass testing without any modification resulted in a drastically reduced sensitivity of only 12. [26] In particular, the reading behaviour of L2 German learners revealed that they were sensitive to both lexical (synonyms) and syntactic (active/passive alternation) substitutions during a second reading of the texts, while L1 exhibited only reduced sensitivity to the lexical substitutions. [27] The pathogen is controlled traditionally through the use of maize cultivars having reduced sensitivity to the disease. [28] BACKGROUND Recently, reduced sensitivity to thyroid hormone as a more common finding in the general population and its possible association with metabolic parameters has been the focus of attention. [29] Results from simulations demonstrate that the HFA-bSSFP reference image results in improved precision and reduced sensitivity to effective FA compared with conventional techniques using a PD reference image. [30] The use of at least two codes reduced sensitivity, but increased specificity. [31] Fiber addition to CEAM not only enhanced the cycles of fatigue loading but also reduced sensitivity to changes in stress level. [32] According to our findings, the frequent short-term trends of negative economic development result in a reduced sensitivity of the labour market to the changes in economic performance, manifested by a lower employment elasticity compared to its values in economies with a stable development trend. [33] RESULTS Except for PPT at both test sides at 1W and 1M, all QST values indicated a significantly reduced sensitivity (P<0. [34] In the loss-of-function rabe1c mutant, both stomatal closure and the whole plant drought stress response showed a reduced sensitivity to ABA treatment, demonstrating that RabE1c is involved in the control over transpirative water loss through the stomata. [35] Functional studies employing heterologous reconstitution model systems and patient-derived tumor cell lines establish that NTRK3G623A and NTRK3G623E mutated kinases exhibit reduced sensitivity to entrectinib and selitrectinib, as well as other NTRK inhibitors tested herein. [36] Older adults have shown reduced sensitivity to reward in decision paradigms, but there is little research relating reward and motor performance in older adults. [37] This results in a lower number of crossbridges in force-producing states, lower average force per crossbridge, and a reduced sensitivity of the contractile proteins to Ca2+, altogether impairing force output. [38] A reduced sensitivity of BN compared to SD carotid bodies was found. [39] Here we report chronic SARS-CoV-2 with reduced sensitivity to neutralising antibodies in an immune suppressed individual treated with convalescent plasma, generating whole genome ultradeep sequences over 23 time points spanning 101 days. [40] Nevertheless, current rationality-impairment models do not account for the fact that (a) equivalently irrational beliefs can be induced through adaptive social cognitive processes, reflecting social integration rather than impairment; (b) delusions are overwhelmingly socially themed; and (c) delusions show a reduced sensitivity to social context both in terms of how they are shaped and how they are communicated. [41] Background The characterisation of the peripheral immune system in the autoimmune disease systemic lupus erythematosus (SLE) at the single-cell level has been hampered by the reduced sensitivity of current whole-transcriptomic technologies. [42] Here, we show that adult flies that developed on ethanol-supplemented medium have decreased viability, reduced sensitivity to ethanol, and disrupted sleep and activity patterns. [43] Three to seven months later, reduced sensitivity was still reported by 52. [44] Whilst the global impact of hypoxia on DNA repair gene expression is likely to lead to genomic instability, tumorigenesis and reduced sensitivity to anti-cancer treatment, treatment re-sensitising might require additional approaches to a simple HIF inhibition. [45] While otolith shape proved to be a reliable phenotypic tracer in distinguishing farmed from wild and farm-associated fish, reduced sensitivity was found between individuals residing in the vicinity of tuna farms and wild ones. [46] Incorporation of a benzylamide substituent onto the aryl azide group increased the hydrophobicity of the particles and encapsulation of hydrophilic cargo but reduced sensitivity to H2S, likely due to the reduced penetration of HS- into the bilayer. [47] In addition, the osmkkk62/70 double mutant showed reduced sensitivity to Brassinosteroids (BRs). [48] The results revealed that expressions of three ABC-G transporters were involved in reduced sensitivity to multiple fungicides including fluopyram. [49] Puberty onset depends upon an increase in pulsatile GnRH/LH secretion, which in sheep is the result of reduced sensitivity to estrogen negative feedback. [50]值得注意的是，在不影响 FerT 表达的情况下选择性敲除 fer 基因会降低 SWΔFer/FerT 细胞对二甲双胍和缺氧的敏感性。 [1] 与二酰胺类杀虫剂一样，G4946E 突变大大降低了对 pyrrole-2-carboxamides 的敏感性。 [2] 许多因素已被认为有助于芬太尼的致死性，包括快速起效、体内效力、配体偏倚、肌肉僵硬的诱导和对纳洛酮逆转的敏感性降低。 [3] 与降低的敏感性一致，与 B73 相比，Mo17 中的 ZmFACS 表达显着降低。 [4] 在 OMI 和 MAX-DOAS VCD 之间观察到的巨大差异归因于地表附近卫星产品的灵敏度降低以及通常存在于 MCMA 混合层中的大气溶胶负载。 [5] 此外，对 SQ109 具有抗性的寄生虫的选择表明可药用 V 型 H + -ATP 酶会降低敏感性。 [6] 在革兰氏阴性菌中，最常见的导致眼部感染的病原体是铜绿假单胞菌，其特点是对抗生素和消毒剂的敏感性降低。 [7] 父亲尼古丁暴露降低了男性对尼古丁诱导的低温的敏感性，改变了男性和女性的尼古丁代谢物浓度，并降低了女性的血清基础皮质酮水平。 [8] Dithianon 是一种多位点杀菌剂，从未成为嫌疑人的对象，也没有报告敏感性和活性降低。 [9] 结果，仅在 A 样突变细胞中，我们检测到 HOXA5、HOXA10 和 HOXB5 高表达和 p14ARF/p21/p53 通路失调，导致对化疗或 Venetoclax 治疗的敏感性降低，与非A样细胞。 [10] 与鼻咽拭子作为诊断 COVID-19 的标准样本类型相比，3 一些研究报告说唾液样本是一种具有良好诊断性能的非侵入性样本，4,5 而另一些研究则要么有相互矛盾的结果 6，要么警告了在疾病流行率低的门诊环境中使用时敏感性降低。 [11] 这导致这些细胞中 HER2 的磷酸化和降解，导致对 T-DM1 的敏感性丧失或降低。 [12] 然而，长期使用索拉非尼治疗通常会导致肿瘤细胞对药物的敏感性降低，从而导致获得性耐药。 [13] 此外，灵敏度降低 3 倍或 10 倍的模拟检测在大流行初期的灵敏度似乎都 > 95%，但灵敏度会降至 85。 [14] 因此，SA/HC/SiO2 复合薄膜可以代表一种简单、经济和可持续的包装材料替代品，降低对水蒸气的敏感性。 [15] 在常规激素治疗因敏感性降低而失败的情况下，它可能具有未来靶向 GH/PRL 敏感性的潜力。 [16] 使用从住院 COVID-19 患者身上收集的面罩过滤器和鼻咽拭子对 SARS-CoV-2 进行测试表明，过滤器样本的敏感性降低 (8. [17] SCDAE与具有不同损坏程度的堆叠卷积自编码器（SCAE）之间的比较研究表明，SCDAE对具有不同损坏比例的随机扰动表现出降低的敏感性，并且具有增强的识别在合理范围内变化的地球化学异常的能力。 [18] 同时，它大大降低了对漂移的敏感性，增加了面包板的稳定性和可靠性。 [19] 突变体对生长素介导的愈伤组织形成和根伸长抑制以及苯硼酸 (PBA) 介导的静脉形成抑制的敏感性降低。 [20] 然而，形成生物膜的细菌对纳米颗粒的敏感性降低。 [21] 我们得出的结论是，仅依赖于 RDT 的疟疾监测需要完善的质量控制程序，以评估 RDT 敏感性和特异性降低对疟疾控制计划的范围和影响。 [22] 本文介绍了一种基于 E/F2 类拓扑的 GaN HEMT 异相功率放大器 (PA)，该拓扑对可变电阻负载操作的敏感性降低，旨在以高效率在扩展范围内提供输出功率控制。 [23] 持续呼吸暂停超过 4 分钟的屏气潜水员 (BHD) 的特点是对释放活性氧的抵抗力、对缺氧的敏感性降低以及骨骼肌中线粒体耗氧量低，类似于北象海豹。 [24] 肝细胞癌患者对索拉非尼的反应各不相同，许多反应者在长期治疗后敏感性降低。 [25] 虽然我们观察到大约 77% 的灵敏度 在接近理想质量的冻融基质中，我们的方法 在直接胴体测试中模拟现场条件，无需任何 修改导致仅的灵敏度大大降低 12. [26] 特别是，二语德语学习者的阅读行为表明，他们在第二次阅读文本时对词汇（同义词）和句法（主动/被动交替）替换都很敏感，而二语德语学习者对词汇替换的敏感度只降低了。 [27] 传统上，通过使用对疾病敏感性降低的玉米品种来控制病原体。 [28] 背景 最近，对甲状腺激素的敏感性降低作为一般人群中更常见的发现及其与代谢参数的可能关联一直是关注的焦点。 [29] 模拟结果表明，与使用 PD 参考图像的传统技术相比，HFA-bSSFP 参考图像可提高精度并降低对有效 FA 的敏感性。 [30] 使用至少两个代码降低了敏感性，但增加了特异性。 [31] 在 CEAM 中添加纤维不仅增强了疲劳载荷的循环，而且降低了对应力水平变化的敏感性。 [32] 根据我们的研究结果，经济负发展的短期趋势频繁导致劳动力市场对经济表现变化的敏感性降低，表现为就业弹性低于其在发展趋势稳定的经济体中的价值。 [33] 结果 除了在 1W 和 1M 的测试侧的 PPT 外，所有 QST 值都表明灵敏度显着降低（P<0. [34] 在功能丧失的rabe1c突变体中，气孔关闭和全株干旱胁迫响应均显示出对ABA处理的敏感性降低，这表明RabE1c参与了通过气孔的蒸腾水分流失的控制。 [35] 使用异源重建模型系统和患者来源的肿瘤细胞系的功能研究表明，NTRK3G623A 和 NTRK3G623E 突变激酶对恩曲替尼和司利曲替尼以及本文测试的其他 NTRK 抑制剂的敏感性降低。 [36] 老年人在决策范式中表现出对奖励的敏感性降低，但很少有研究涉及老年人的奖励和运动表现。 [37] 这导致产生力状态下的横桥数量减少，每个横桥的平均力降低，收缩蛋白对 Ca2+ 的敏感性降低，完全削弱了力输出。 [38] 发现与 SD 颈动脉体相比，BN 的敏感性降低。 [39] 在这里，我们报告了用恢复期血浆治疗的免疫抑制个体对中和抗体的敏感性降低的慢性 SARS-CoV-2，在 101 天的 23 个时间点产生全基因组超深序列。 [40] 然而，目前的理性损害模型并没有解释以下事实：（a）通过适应性社会认知过程可以诱发同等的非理性信念，反映社会整合而不是损害； (b) 妄想绝大多数以社会为主题； (c) 妄想表现出对社会背景的敏感性降低，无论是在它们如何形成和如何交流方面。 [41] 背景 自身免疫性疾病系统性红斑狼疮 (SLE) 外周免疫系统在单细胞水平上的表征受到当前全转录组技术敏感性降低的阻碍。 [42] 在这里，我们表明，在补充乙醇的培养基上发育的成蝇活力降低，对乙醇的敏感性降低，睡眠和活动模式被打乱。 [43] 三到七个月后，仍有 52 人报告敏感性降低。 [44] 虽然缺氧对 DNA 修复基因表达的全球影响可能导致基因组不稳定、肿瘤发生和对抗癌治疗的敏感性降低，但治疗重新敏感可能需要额外的方法来抑制简单的 HIF。 [45] 虽然耳石形状被证明是区分养殖鱼类和野生鱼类和农场相关鱼类的可靠表型示踪剂，但发现居住在金枪鱼养殖场附近的个体和野生鱼类之间的敏感性降低。 [46] 在芳基叠氮基上加入苄酰胺取代基增加了颗粒的疏水性和亲水性货物的包封，但降低了对 H2S 的敏感性，这可能是由于 HS- 进入双层的减少。 [47] 此外，osmkkk62/70 双突变体对油菜素类固醇 (BRs) 的敏感性降低。 [48] 结果表明，三种 ABC-G 转运蛋白的表达与包括氟吡菌酰胺在内的多种杀真菌剂的敏感性降低有关。 [49] 青春期开始取决于脉动 GnRH/LH 分泌的增加，这在绵羊中是对雌激素负反馈敏感性降低的结果。 [50]
Showed Reduced Sensitivity
In addition, the osmkkk62/70 double mutant showed reduced sensitivity to Brassinosteroids (BRs). [1] Results Application of TTFields using cyclic repetition significantly decreased proliferation of human glioma and ovarian cancer cells, whereas cells treated using continuous, long-duration application of TTFields showed reduced sensitivity to TTFields. [2] A DSP3 loss-of-function mutant showed reduced sensitivity to salt treatment. [3] In contrast, individuals with overweight or obese BMI (≥25) did not show stronger delay-discounting, but individuals with BMI ≥ 25, and especially females, showed reduced sensitivity to sunk-costs (where their decisions were less sensitive to irrecoverable investments of effort) and less deliberation when presented with difficult offers. [4] Moreover, while monocytic leukemias (AML-M4/M5) showed reduced sensitivity to venetoclax, they were sensitive to trametinib and showed increased expression of MEK1. [5] Compared to the TMAs, the preoperative biopsies showed reduced sensitivity (0. [6] All analogs additionally showed reduced sensitivity to serum. [7] 1%) showed reduced sensitivity to RSA. [8] We observed that MCF7 and T47D BC-derived cells stably over-expressing ETV7 showed reduced sensitivity to the chemotherapeutic drug 5-fluorouracil and to radiotherapy, accompanied by an adaptive proliferative behavior observed in different culture conditions. [9] Utilizing digit abduction score assay by injecting toxins into the leg muscle, we found that Syt1 mutant mice showed similar sensitivity as the wild type mice, whereas Syt2 mutant mice showed reduced sensitivity to BoNT/B, DC, and G, demonstrating that Syt2 is the dominant receptor at skeletal neuromuscular junctions. [10] Lettuce plants pre-treated with 20 μg/mL Bent-DDA showed reduced sensitivity to 2,4-D including an increment on chlorophyll content and biomass compared with non-treated plants. [11] In this study, we established two radioresistant NPC cell lines, HONE1-IR and CNE2-IR, and found that both cell lines showed reduced sensitivity to cisplatin. [12] Accessions B20, B2, and S11 and B49, B51, and S59 showed reduced sensitivity to glyphosate and flumioxazin, respectively. [13]此外，osmkkk62/70 双突变体对油菜素类固醇 (BRs) 的敏感性降低。 [1] 结果使用循环重复应用 TTFields 显着降低了人类神经胶质瘤和卵巢癌细胞的增殖，而使用连续、长期应用 TTFields 处理的细胞对 TTFields 的敏感性降低。 [2] nan [3] nan [4] nan [5] nan [6] nan [7] nan [8] nan [9] nan [10] nan [11] nan [12] nan [13]
Significantly Reduced Sensitivity
RESULTS Except for PPT at both test sides at 1W and 1M, all QST values indicated a significantly reduced sensitivity (P<0. [1] Simulation of the constructed control system showed a significantly reduced sensitivity of the calorific value to the composition of raw materials, and also revealed a low sensitivity of the control quality from the deviations of the time constants of the control object caused by disturbances in the chemical composition of the waste. [2] A total of 18, 11 and 14 of the 25 locations exhibited significantly reduced sensitivity (P. [3] Importantly, we find significantly reduced sensitivity to SSH20 in Cav-1-silenced tumors compared to Cav-1-expressing tumors in vivo. [4] However, nonlinear elastic-plastic analysis shows significantly reduced sensitivity to flaw shape. [5] Here, we show that cells lacking the G protein component Gβ, the Ras guanine nucleotide exchange factor GefA, phosphatase and tensin homolog (PTEN), phospholipase C (PLC), inositol 1,4,5-trisphosphate (IP3) receptor-like protein A (IplA), polyphosphate kinase 1 (Ppk1), or the TOR complex 2 component PiaA have significantly reduced sensitivity to polyphosphate-induced proliferation inhibition. [6] When we combine these with other nonlocal observations, we obtain several constraints on H 0 with significantly reduced sensitivity to early universe physics. [7] Intriguingly, depletion of PTPRK significantly reduced sensitivity to the anti‐cancer drug oxaliplatin and was accompanied by up‐regulation of phosphorylation of Bad, a downstream target of AKT. [8] Besides the possibility of realizing elliptic responses having the maximum number of transmission zeroes, a higher ${Q}$ -factor as well as a significantly reduced sensitivity to manufacturing imperfections is the main benefit making these structures especially suitable for the practical realization of very narrowband millimeter-wave filters. [9]结果 除了在 1W 和 1M 的测试侧的 PPT 外，所有 QST 值都表明灵敏度显着降低（P<0. [1] 所构建的控制系统的模拟显示热值对原材料成分的敏感性显着降低，并且还揭示了控制质量对化学成分扰动引起的控制对象时间常数偏差的低敏感性的废物。 [2] nan [3] nan [4] nan [5] nan [6] nan [7] nan [8] nan [9]
Exhibit Reduced Sensitivity
Functional studies employing heterologous reconstitution model systems and patient-derived tumor cell lines establish that NTRK3G623A and NTRK3G623E mutated kinases exhibit reduced sensitivity to entrectinib and selitrectinib, as well as other NTRK inhibitors tested herein. [1] The hop3-1 mutant exhibits reduced sensitivity to JA derivatives in root growth assays and downregulation of different JA-responsive genes in response to methyl jasmonate, further revealing the relevance of HOP3 in the JA pathway. [2] Then, we examine the extent to which individuals who demonstrate compromised mentalizing, such as those with schizophrenia or autism, may exhibit reduced sensitivity to rejection (e. [3] ARAF mutations may serve as a general resistance mechanism for RAF dimer inhibitors as the mutants exhibit reduced sensitivity to a panel of type II RAF inhibitors. [4] The linewidth is orders of magnitudes smaller than that of the cavity as well as the inhomogeneous gain broadening and exhibits reduced sensitivity to cavity frequency noise. [5] Furthermore, Arabidopsis lines expressing the bccrh1 gene exhibit reduced sensitivity to B. [6]使用异源重建模型系统和患者来源的肿瘤细胞系的功能研究表明，NTRK3G623A 和 NTRK3G623E 突变激酶对恩曲替尼和司利曲替尼以及本文测试的其他 NTRK 抑制剂的敏感性降低。 [1] hop3-1 突变体在根生长试验中表现出对 JA 衍生物的敏感性降低，并下调了不同 JA 响应基因对茉莉酸甲酯的反应，进一步揭示了 HOP3 在 JA 途径中的相关性。 [2] nan [3] nan [4] nan [5] nan [6]