Real World Validation(真实世界验证)研究综述
Real World Validation 真实世界验证 - Background and Aims: The aims of this study were to establish a maximum standardized uptake value (SUVmax) cutoff to discriminate clinically significant prostate cancer (csPCa) from benign prostate disease (BPD) by 68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) in patients with suspected prostate cancer (PCa), and to perform a prospective real-world validation of this cutoff value. [1] The easing of mobility restrictions in June 2020 and subsequent scale-up of testing and tracing programs through September provided real-world validation of our predictions. [2] Real-world validation of the rule identified in this post hoc analysis is merited. [3] Results A 10 metabolic gene-based signature was constructed and verified as a robust and independent prognostic classifier in public and real-world validation cohorts. [4] In the process of simulation experiments and real-world validations, our proposed method is compared with the basic particle swarm optimization and A-star method in four simulation scenarios and four real-world maps, and the comparative study show that the proposed algorithm outperforms as well as particle swarm optimization and A-star algorithms in terms of path length, running time, path optimal degree, and stability. [5] For real-world validation of two biomarkers (study 2), other participants in the KCPS-II cohort who had IFG at baseline (n = 500) were selected. [6] With refined training schemes and real-world validation, these tools can be deployed to automatically measure and monitor swallowing in the clinic and community for patients across the impairment spectrum. [7] Collection of data from four subjects performing standardized clinical tasks while in wheelchairs allowed for real-world validation of the 3D simulation model. [8] Data from monitoring program samples in Mahone Bay, NS, are presented as a real-world validation of findings. [9] Further real-world validation demonstrates SNOMED-CT extraction at 3 large London hospitals with self-supervised training over ∼8. [10] The combination of these modeling techniques and real-world validation demonstrates a methodology for a cost effective means of rapidly developing and validating high performance EV powertrains, filling the literature gaps in how these modeling methodologies can be carried out in a research framework. [11] Testing and real-world validation cohorts were used to identify predictive responses for immune checkpoint therapies (ICTs) of m6AMS. [12] The aim of this study was to examine powered mobility aid access on test rigs specified in the standard to determine public transport conformance thus contributing to real-world validation of the standard, and identify the measurements of mobility aids most likely to access public transport. [13]背景和目的：本研究的目的是通过 68Ga 标记的前列腺特异性膜抗原（68Ga-PSMA -11) 对疑似前列腺癌 (PCa) 患者进行正电子发射断层扫描/计算机断层扫描 (PET/CT)，并对该临界值进行前瞻性现实世界验证。 [1] 2020 年 6 月放宽了出行限制，随后到 9 月扩大了测试和追踪计划，为我们的预测提供了现实验证。 [2] 值得对该事后分析中确定的规则进行实际验证。 [3] 结果 构建了 10 个基于代谢基因的签名，并在公共和现实世界验证队列中验证为稳健且独立的预后分类器。 [4] 在仿真实验和真实世界验证过程中，我们提出的方法在四个仿真场景和四个真实世界地图中与基本粒子群优化和 A-star 方法进行了比较，对比研究表明，该算法的性能优于在路径长度、运行时间、路径最优度、稳定性等方面进行了粒子群优化和A-star算法。 [5] 对于两种生物标志物的真实世界验证（研究 2），选择了 KCPS-II 队列中在基线时具有 IFG 的其他参与者（n = 500）。 [6] 通过完善的培训计划和真实世界的验证，可以部署这些工具来自动测量和监测诊所和社区中各种障碍患者的吞咽情况。 [7] 从四名坐在轮椅上执行标准化临床任务的受试者收集的数据允许对 3D 模拟模型进行真实世界的验证。 [8] 来自新罕布什尔州马洪湾监测项目样本的数据作为对调查结果的真实验证呈现。 [9] 进一步的真实世界验证表明，在伦敦 3 家大型医院进行 SNOMED-CT 提取，自我监督训练超过 8 次。 [10] 这些建模技术与实际验证相结合，展示了一种快速开发和验证高性能 EV 动力系统的经济有效方法，填补了如何在研究框架中执行这些建模方法的文献空白。 [11] 测试和真实世界验证队列用于确定 m6AMS 免疫检查点疗法 (ICT) 的预测反应。 [12] 本研究的目的是检查标准中指定的测试台上的电动助行器访问，以确定公共交通的一致性，从而有助于标准的实际验证，并确定最有可能进入公共交通的助行器的测量值。 [13]