Proteins Inside(里面的蛋白质)研究综述
Proteins Inside 里面的蛋白质 - Proteins inside the living cell are exposed to a highly crowded and heterogeneous environment, which may substantially affect their properties and, consequently, their function. [1] 5 leads to the formation of stable, large and porous whey protein microparticles (PMs), resulting from the crosslinking of proteins inside the powder. [2] Funding information DST, New Delhi, India Ubiquitination is an important post-translational event responsible for half-life and turnover of proteins inside the cell. [3] Affectations in the lipid region of the plasma membrane affect the transduction of mechanical forces, and any molecule that modifies the biophysical integrity of the lipid bilayer can alter the mechanical activity of the proteins inside the membrane. [4] The small ubiquitin-like modifier (SUMO) is a post-translational modifier that can regulate the function of hundreds of proteins inside the cell. [5] To gain structural information of the proteins inside the living cells at an atomic resolution, in-cell NMR method has been developed for the past two decades. [6] Most of the computational methods used to predict protein complexes were based on the principle that proteins inside the complex have more interactions. [7] Lung surfactant (LS), a thin layer of phospholipids and proteins inside the alveolus of the lung is the first biological barrier to inhaled nanoparticles (NPs). [8] In contrast, the concentrations of proteins inside the injection region may be dramatically smaller than those outside, and the ratio of these two concentrations for proteins of different size may be much higher, by a few orders of magnitude, for smaller proteins. [9] The folding and unfolding of proteins inside a cell take place in the presence of macromolecules of various shapes and sizes. [10] By obtaining a cross section of the desired location of the neurons by FIB milling under the SEM imaging condition, it was possible to observe the proteins inside the cells as clear bright spots. [11] It is helpful to analyze each type of proteins inside the family separately and study the role of functional loops -structural features that significantly influence on biological activity. [12] Disulfide bonds play a critical role in a variety of structural and mechanistic processes associated with proteins inside the cells and in the extracellular environment. [13]活细胞内的蛋白质暴露在高度拥挤和异质的环境中，这可能会严重影响它们的特性，从而影响它们的功能。 [1] 5 导致形成稳定、大而多孔的乳清蛋白微粒 (PM)，这是由于粉末内部蛋白质的交联而产生的。 [2] 资金信息 DST，印度新德里 泛素化是一个重要的翻译后事件，负责细胞内蛋白质的半衰期和周转。 [3] 质膜脂质区域的影响会影响机械力的传递，任何改变脂质双层生物物理完整性的分子都可以改变膜内蛋白质的机械活性。 [4] 小泛素样修饰剂（SUMO）是一种翻译后修饰剂，可以调节细胞内数百种蛋白质的功能。 [5] 为了以原子分辨率获得活细胞内蛋白质的结构信息，细胞内核磁共振方法已经发展了二十年。 [6] 大多数用于预测蛋白质复合物的计算方法都是基于复合物中的蛋白质具有更多相互作用的原理。 [7] 肺表面活性剂 (LS) 是肺泡内的一层薄薄的磷脂和蛋白质，是吸入纳米颗粒 (NPs) 的第一个生物屏障。 [8] 相比之下，注射区域内的蛋白质浓度可能比外部的要小得多，对于较小的蛋白质，不同大小的蛋白质的这两种浓度的比率可能要高出几个数量级。 [9] 细胞内蛋白质的折叠和展开是在各种形状和大小的大分子存在的情况下发生的。 [10] 通过在 SEM 成像条件下通过 FIB 铣削获得神经元所需位置的横截面，可以将细胞内的蛋白质观察为清晰的亮点。 [11] 分别分析家族中每种类型的蛋白质并研究功能环的作用 - 对生物活性有显着影响的结构特征是有帮助的。 [12] 二硫键在与细胞内和细胞外环境中的蛋白质相关的各种结构和机械过程中起关键作用。 [13]
Recombination Proteins Inside 内部重组蛋白
The damage may contain long stretches of single-stranded DNAs (ssDNAs), which lead to aggregate formation of a ssDNA binding protein, RPA, and a RecA homolog, Rad51, as well as other recombination proteins inside of the nuclei. [1] The damage may contain long stretches of single-stranded DNAs (ssDNAs), which lead to aggregate formation of a ssDNA binding protein, RPA, and a RecA homolog, Rad51, as well as other recombination proteins inside of the nuclei, but not that of a meiosis-specific Dmc1. [2]损伤可能包含长链单链 DNA (ssDNA)，这会导致 ssDNA 结合蛋白 RPA 和 RecA 同源物 Rad51 以及细胞核内的其他重组蛋白的聚集形成。 [1] 损伤可能包含长长的单链 DNA (ssDNA)，导致 ssDNA 结合蛋白 RPA 和 RecA 同源物 Rad51 以及细胞核内的其他重组蛋白聚集形成，但不是减数分裂特异性 Dmc1。 [2]
proteins inside cell 细胞内的蛋白质
In addition, spatially-resolved maps of lipids and proteins inside cells and three dimensional reconstructions of lipids at the initial and final steps of adipocyte differentiation are reported, too. [1] New biodegradable nanoparticles shuttle proteins inside cells and enable robust gene editing. [2] To fully understand the functions and physical properties of proteins inside cells, it is indispensable to obtain explicit structural data or determine three-dimensional (3D) structures of proteins in cells. [3]此外，还报道了细胞内脂质和蛋白质的空间分辨图以及脂肪细胞分化的初始和最后步骤中脂质的三维重建。 [1] 新的可生物降解纳米粒子在细胞内穿梭蛋白质并实现稳健的基因编辑。 [2] 要充分了解细胞内蛋白质的功能和物理性质，必须获得明确的结构数据或确定细胞内蛋白质的三维（3D）结构。 [3]
proteins inside living 生活中的蛋白质
This probe exhibits high quantum yields and improved solubility, offering a new opportunity for imaging intracellular His6-tagged proteins inside living cells with better contrast. [1] Fluorescent proteins (FPs) have revolutionized cell biology by allowing genetic tagging of specific proteins inside living cells. [2]该探针表现出高量子产率和更高的溶解度，为以更好的对比度对活细胞内的细胞内 His6 标记蛋白进行成像提供了新的机会。 [1] 荧光蛋白 (FP) 通过允许对活细胞内的特定蛋白质进行基因标记，彻底改变了细胞生物学。 [2]
proteins inside exosome 外泌体内的蛋白质
RNaseA and neutralizing antibodies treatment studies suggest the presence of viral RNA/proteins inside exosomes. [1] These results indicate that the loading of antigen proteins inside exosomes helps in efficient antigen presentation. [2]RNaseA 和中和抗体治疗研究表明外泌体内存在病毒 RNA/蛋白质。 [1] 这些结果表明，外泌体中抗原蛋白的负载有助于有效的抗原呈递。 [2]