Potential Antitubercular(潜在的抗结核药)研究综述
Potential Antitubercular 潜在的抗结核药 - Finally, the chapter will cover the future directions for overcoming the current challenges in the discovery and synthesis of potential antitubercular peptides for use as peptide drugs. [1] The chorismate mutase (CM) is considered as an attractive target for the identification of potential antitubercular agents due to its absence in animals but not in bacteria. [2] The performance of different modules of the proposed method has been investigated by considering two different series of bioactive compounds: (1) convulsant and anticonvulsant barbiturates and (2) nucleoside analogues with their activities against HIV and a data set of 3779 potential antitubercular compounds. [3] In addition, compound 7 was discovered to display potential antitubercular activity for the first time. [4] Thus, our study identifies numerous potential antitubercular drug targets and provides a comprehensive picture of the complexity of M. [5] This work provides key insights into the structure, binding mechanisms, and degradation of β-lactams by LdtMt3, which may be useful for the development of additional β-lactams with potential antitubercular activity. [6]最后，本章将介绍克服目前在发现和合成用作肽药物的潜在抗结核肽方面面临的挑战的未来方向。 [1] 分支酸变位酶 (CM) 被认为是识别潜在抗结核药物的有吸引力的目标，因为它在动物中不存在，但在细菌中不存在。 [2] 通过考虑两个不同系列的生物活性化合物，研究了所提出方法的不同模块的性能：（1）惊厥和抗惊厥巴比妥类药物和（2）具有抗 HIV 活性的核苷类似物和 3779 种潜在抗结核化合物的数据集。 [3] 此外，化合物 7 首次被发现具有潜在的抗结核活性。 [4] 因此，我们的研究确定了许多潜在的抗结核药物靶点，并全面了解了结核分枝杆菌的复杂性。 [5] 这项工作为 LdtMt3 对 β-内酰胺的结构、结合机制和降解提供了重要见解，这可能有助于开发具有潜在抗结核活性的其他 β-内酰胺。 [6]
potential antitubercular activity 潜在的抗结核活性
In addition, compound 7 was discovered to display potential antitubercular activity for the first time. [1] This work provides key insights into the structure, binding mechanisms, and degradation of β-lactams by LdtMt3, which may be useful for the development of additional β-lactams with potential antitubercular activity. [2]此外，化合物 7 首次被发现具有潜在的抗结核活性。 [1] 这项工作为 LdtMt3 对 β-内酰胺的结构、结合机制和降解提供了重要见解，这可能有助于开发具有潜在抗结核活性的其他 β-内酰胺。 [2]