Popart Trial(波帕特审判)研究综述
Popart Trial 波帕特审判 - Methods Using an individual-based model, we simulated the PopART intervention and standard care with antiretroviral therapy (ART) provided according to national guidelines for the 21 trial communities in Zambia and South Africa (for all individuals aged >14 years), with model parameters and primary cost data collected during the PopART trial and from published sources. [1] Outcomes ranged from no impact on HIV incidence in the South African TasP trial (likely due to suboptimal linkage to care), no impact on HIV incidence in Uganda and Kenya (likely due to the minimal differences in treatment efforts between the intervention and control communities), a 31%-38% reduction in HIV incidence in Botswana, with its statistical significance depending on the statistical analysis used to a 31% reduction in the PopART trial but only in the group with the less intensive treatment intervention. [2]方法 使用基于个体的模型，我们使用模型参数模拟了根据国家指南为赞比亚和南非的 21 个试验社区（适用于所有年龄 >14 岁的个体）提供的抗逆转录病毒疗法 (ART) 的 PopART 干预和标准护理在 PopART 试验期间和从已发布的来源收集的主要成本数据。 [1] 结果的范围从对南非 TasP 试验中的 HIV 发病率没有影响（可能是由于与护理的联系不理想），对乌干达和肯尼亚的 HIV 发病率没有影响（可能是由于干预和控制社区之间的治疗工作差异很小） ，博茨瓦纳的 HIV 发病率降低了 31%-38%，其统计学意义取决于用于 PopART 试验降低 31% 的统计分析，但仅限于治疗干预强度较低的组。 [2]