Polyelectrolyte Complexation(聚电解质络合)研究综述
Polyelectrolyte Complexation 聚电解质络合 - Insecticide cartap hydrochloride (C) was fabricated as nanospheres by a two-step method of ionic gelification and polyelectrolyte complexation of alginate (ALG) and chitosan (CS) to undermine its adverse effects on environment. [1] The effective approaches for encapsulating copigmented anthocyanins are described, including spray/freeze-drying, emulsification, gelation, polyelectrolyte complexation, and their combinations. [2] Magnetic-pectin microspheres were obtained by ionotropic gelation followed by polyelectrolyte complexation with chitosan. [3] Polyelectrolyte complexation is driven by associative interactions between oppositely charged polyelectrolytes, resulting in formation of a macroscopic polymer dense phase and a polymer dilute phase with applications in coatings, adhesives, and purification membranes. [4] Once supra-folded, origamis can be switched back on the surface into their 2D original shape through addition of heparin, a highly charged anionic polyelectrolyte known as an efficient competitor of DNA-polyelectrolyte complexation. [5] Polyelectrolyte complexation with chitosan by electrostatic interaction stabilized the succinylated protein-curcumin complex. [6] Furthermore, some non-covalent strategies, such as polyelectrolyte complexation, have been reported for the preparation of aptamer–polymer conjugates. [7] The polyelectrolyte complexation between CHI polycation and CNF polyanion was then triggered by desalting the CHI/CNF aqueous mixture by multistep dialysis, in large excess of chitosan. [8] In particular, we focus on cyclodextrin (CD)-based pharmaceutics and polyelectrolyte complexation of growth factors to enhance their solubility, stability, and bioactivity. [9] Polyelectrolyte complexation is a technique based on interactions between polyelectrolytes of opposite charges driven by supramolecular interactions. [10] Nanoparticles (NPs) based on gellan gum (GG) and retrograded starch (RS) were rationally designed through polyelectrolyte complexation, and ionic cross-linking was exploited as an additional technological strategy to modulate the properties of nanocarriers. [11] An environmentally friendly chemical preparation based on polyelectrolyte complexation was used. [12] Polyelectrolyte complexation (PEC) allowed the glycerol-plasticised chitosan/CMC material to have a hydrophobic surface (contact angle: 90 ± 6°) similar to that of the un-plasticised chitosan/CMC/MMT material. [13] Polyelectrolyte complexation with chitosan by electrostatic interaction stabilized the succinylated protein-curcumin complex. [14] A continued interest in polyelectrolyte phase diagrams guides the study of interfacial phenomena driven by polyelectrolyte complexation. [15] Nanoparticles (NPs) based on gellan gum (GG) and chitosan (CS) blends were prepared through polyelectrolyte complexation. [16] The magnetic microrobot, with a multilayer capsule helical structure, was developed via multifunctional strategies, including microfluidic synthesis, polyelectrolyte complexation, and surface coating with magnetic nanoparticles. [17] Herein, we investigate if polyelectrolyte complexation-induced APS ultrafiltration membranes can be the basis for different types of nanofiltration membranes. [18] The role of polyelectrolyte–solvent interactions, among other non-Coulomb interactions, in dictating the thermodynamics and kinetics of polyelectrolyte complexation is prominent yet sparingly studi. [19] We present the simultaneous synthesis of a hollow fiber membrane with a selective layer created by means of polyelectrolyte complexation (PEC), to be used as a membrane in forward osmosis. [20] Finally, microparticles were formed by a polyelectrolyte complexation and gelation. [21] Two types of nanocarriers were prepared using interpolyelectrolyte complexation between these polymers. [22] Previously, we developed high-payload amorphous nanoparticle complex (or nanoplex) of CUR and chitosan (CHI) capable of CUR solubility enhancement by drug-polyelectrolyte complexation. [23] Polyelectrolyte complex (PEC) hydrogels composed of sodium carboxymethyl cellulose and chitosan reinforced with halloysite nanotubes (HNTs) and graphene oxide (GO) were prepared by polyelectrolyte complexation under acidic environment. [24] Polyelectrolyte complexation, the combination of anionically and cationically charged polymers through ionic interactions, can be used to form hydrogel networks. [25] In this study, four nanoparticles formulations (F1 to F4) comprised of varying ratios of alginate, Pluronic F-68 and calcium chloride with a constant amount of insulin and chitosan as a coating material were prepared using polyelectrolyte complexation and ionotropic gelation methods to protect insulin against enzymatic degradation. [26] In the current study, carboxymethyl cellulose/N-2-hydroxylpropyl trimethyl ammonium chloride chitosan (CMC/HACC) composite fibers were fabricated by polyelectrolyte complexation (PEC) and freeze drying coupled method in both pure water and NaCl solution. [27] They can be formed through several supramolecular pathways, ranging from phase inversion in alkaline solutions, to the ionic crosslinking of chitosan with multivalent anions, to polyelectrolyte or surfactant/polyelectrolyte complexation. [28] MATERIALS AND METHODS Nanoparticles were prepared using polyelectrolyte complexation from chitosan and dextran sulfate. [29] Polyelectrolyte complexation (PEC) is an associative phase separation process initiated by mixing of two kinds of oppositely charged polyelectrolyte solutions. [30] However the wet adhesion was dominated by polyelectrolyte complexation, and the presence of hydrazone linkages had little influence on wet adhesion. [31] Reported here is a new class of PICsomes (vesicles formed by polyelectrolyte complexation) in which the anionic/neutral diblock copolymer is replaced by an anionic, reversible, supramolecular polyelectrolyte based on metal-ligand coordination. [32] Polyelectrolyte complexation between oppositely charged polyelectrolytes forms coacervates in dilute solutions and thin films in concentrated solutions. [33] Baroplastics with tacky properties were generated by a mild assembly process based on polyelectrolyte complexation and compaction. [34] In these techniques, mixing is achieved on a time commensurate with the time scales of hydrophobic polymer precipitation or polyelectrolyte complexation, thus enabling the controlled fabrication of nanoparticles and nanocomplexes, respectively. [35] Self-coacervation of a cationic polyelectrolyte (polyamidoamine-epichlorohydrin, PAE-Cl) occurs in broader conditions when its original counter anion (Cl- ) is exchanged by bis(trifluoromethane-sulphonyl)imide anion (TFSI- ), as a result of TFSI- counter anions association instead of polyelectrolyte complexation. [36] Polyelectrolyte complexation is a versatile platform for the design of self-assembled materials. [37] Using kinetic models of amphiphilic block copolymer micelles in polyelectrolyte complexation-driven micelles, we derive an analytical expression for dissociation relaxation rates as a function of solvent temperature, salt concentration, and the length of the charged polymer blocks. [38] 75 M, complex coacervate core micelles (C3M) with a PNIPAM corona were formed as a result of interpolyelectrolyte complexation. [39] BACKGROUND In this study, four nanoparticle formulations (F1 to F4) comprising varying ratios of alginate, Pluronic F-68 and calcium chloride with a constant amount of insulin and chitosan as a coating material were prepared using polyelectrolyte complexation and ionotropic gelation methods to protect insulin against enzymatic degradation. [40] Numerous methods, such as, chemical crosslinking, photo crosslinking, graft polymerization, hydrophobic interaction, polyelectrolyte complexation and electrodeposition have been employed to prepare polysaccharide and protein hydrogels. [41] Methods: Insulin (Ins) was incorporated into the MMA/IA nanogels (NGs) using the polyelectrolyte complexation (PEC) method to form Ins/NGs-PEC. [42] The liquid mixture of CMCS and alginate solutions formed a gel by polyelectrolyte complexation after addition of d-glucono-δ-lactone (GDL), which slowly hydrolyzed and donated protons. [43]通过离子凝胶化和藻酸盐（ALG）和壳聚糖（CS）的聚电解质络合两步法，将杀虫剂杀虫剂cartap盐酸盐（C）制成纳米球，以消除其对环境的不利影响。 [1] 描述了包封共色素花青素的有效方法，包括喷雾/冷冻干燥、乳化、凝胶化、聚电解质络合及其组合。 [2] 磁性果胶微球是通过离子凝胶化然后聚电解质与壳聚糖络合获得的。 [3] 聚电解质络合是由带相反电荷的聚电解质之间的缔合相互作用驱动的，导致形成宏观聚合物密相和聚合物稀相，可应用于涂料、粘合剂和净化膜。 [4] 一旦超折叠，折纸可以通过添加肝素在表面上转换回它们的 2D 原始形状，肝素是一种高电荷阴离子聚电解质，被称为 DNA-聚电解质络合的有效竞争者。 [5] 聚电解质通过静电相互作用与壳聚糖络合稳定了琥珀酰化的蛋白质-姜黄素复合物。 [6] 此外，已经报道了一些非共价策略，例如聚电解质络合，用于制备适体-聚合物缀合物。 [7] CHI 聚阳离子和 CNF 聚阴离子之间的聚电解质络合随后通过多步透析使 CHI/CNF 水性混合物脱盐而触发，其中壳聚糖大量过量。 [8] 特别是，我们专注于基于环糊精 (CD) 的药物和生长因子的聚电解质络合，以提高它们的溶解度、稳定性和生物活性。 [9] 聚电解质络合是一种基于由超分子相互作用驱动的相反电荷聚电解质之间相互作用的技术。 [10] 基于结冷胶（GG）和回生淀粉（RS）的纳米颗粒（NPs）通过聚电解质络合合理设计，离子交联被用作调节纳米载体性质的附加技术策略。 [11] 使用基于聚电解质络合的环保化学制剂。 [12] 聚电解质络合 (PEC) 使甘油增塑壳聚糖/CMC 材料具有与未增塑壳聚糖/CMC/MMT 材料相似的疏水表面（接触角：90 ± 6°）。 [13] 聚电解质通过静电相互作用与壳聚糖络合稳定了琥珀酰化的蛋白质-姜黄素复合物。 [14] 对聚电解质相图的持续兴趣引导着对由聚电解质络合驱动的界面现象的研究。 [15] 通过聚电解质络合制备基于结冷胶 (GG) 和壳聚糖 (CS) 混合物的纳米颗粒 (NPs)。 [16] 具有多层胶囊螺旋结构的磁性微型机器人是通过多功能策略开发的，包括微流体合成、聚电解质络合和磁性纳米粒子表面涂层。 [17] 在此，我们研究了聚电解质络合诱导的 APS 超滤膜是否可以作为不同类型纳滤膜的基础。 [18] 聚电解质-溶剂相互作用以及其他非库仑相互作用在决定聚电解质络合的热力学和动力学方面的作用是突出的，但研究很少。 [19] 我们提出了中空纤维膜的同时合成，该膜具有通过聚电解质络合 (PEC) 创建的选择性层，用作正向渗透中的膜。 [20] 最后，通过聚电解质络合和凝胶化形成微粒。 [21] 使用这些聚合物之间的聚电解质间络合制备两种类型的纳米载体。 [22] 此前，我们开发了 CUR 和壳聚糖 (CHI) 的高负载无定形纳米粒子复合物（或 nanoplex），能够通过药物-聚电解质络合提高 CUR 溶解度。 [23] 在酸性环境下通过聚电解质络合制备了由羧甲基纤维素钠和壳聚糖组成的聚电解质络合物（PEC）水凝胶，该水凝胶由埃洛石纳米管（HNTs）和氧化石墨烯（GO）增强。 [24] 聚电解质络合，即阴离子和阳离子带电聚合物通过离子相互作用的结合，可用于形成水凝胶网络。 [25] 在这项研究中，使用聚电解质络合和离子凝胶法制备了四种纳米颗粒制剂（F1 至 F4），由不同比例的藻酸盐、Pluronic F-68 和氯化钙以及恒定量的胰岛素和壳聚糖作为涂层材料组成，以保护胰岛素抗酶降解。 [26] 本研究采用聚电解质络合（PEC）和冷冻干燥耦合法在纯水和NaCl溶液中制备羧甲基纤维素/N-2-羟丙基三甲基氯化铵壳聚糖（CMC/HACC）复合纤维。 [27] 它们可以通过几种超分子途径形成，范围从碱性溶液中的相转化，到壳聚糖与多价阴离子的离子交联，再到聚电解质或表面活性剂/聚电解质络合。 [28] 材料和方法 使用壳聚糖和硫酸葡聚糖的聚电解质络合制备纳米颗粒。 [29] 聚电解质络合 (PEC) 是由两种带相反电荷的聚电解质溶液混合引发的缔合相分离过程。 [30] 然而，湿附着力以聚电解质络合为主，腙键的存在对湿附着力影响不大。 [31] 这里报道了一类新的 PICsomes（由聚电解质络合形成的囊泡），其中阴离子/中性二嵌段共聚物被基于金属-配体配位的阴离子、可逆、超分子聚电解质取代。 [32] 带相反电荷的聚电解质之间的聚电解质络合在稀溶液中形成凝聚层，在浓溶液中形成薄膜。 [33] 具有粘性的 Baroplastics 是通过基于聚电解质络合和压实的温和组装过程产生的。 [34] 在这些技术中，混合是在与疏水聚合物沉淀或聚电解质络合的时间尺度相称的时间实现的，从而能够分别控制纳米颗粒和纳米复合物的制造。 [35] 阳离子聚电解质（聚酰胺胺-环氧氯丙烷，PAE-Cl）的自凝聚在更广泛的条件下发生，因为 TFSI 导致其原始抗衡阴离子 (Cl-) 被双（三氟甲烷-磺酰）亚胺阴离子 (TFSI-) 交换- 反阴离子缔合而不是聚电解质络合。 [36] 聚电解质络合是设计自组装材料的多功能平台。 [37] 使用聚电解质络合驱动胶束中两亲嵌段共聚物胶束的动力学模型，我们推导出解离松弛率作为溶剂温度、盐浓度和带电聚合物块长度的函数的解析表达式。 [38] 由于聚电解质间络合，形成了具有 PNIPAM 电晕的 75 M 复合凝聚核心胶束 (C3M)。 [39] 背景 在这项研究中，使用聚电解质络合和离子凝胶法制备了四种纳米颗粒制剂（F1 至 F4），包括不同比例的藻酸盐、Pluronic F-68 和氯化钙，并以恒定量的胰岛素和壳聚糖作为涂层材料，以保护胰岛素。抗酶降解。 [40] 许多方法，例如化学交联、光交联、接枝聚合、疏水相互作用、聚电解质络合和电沉积已被用于制备多糖和蛋白质水凝胶。 [41] 方法：使用聚电解质络合 (PEC) 方法将胰岛素 (Ins) 掺入 MMA/IA 纳米凝胶 (NGs) 中以形成 Ins/NGs-PEC。 [42] CMCS和海藻酸盐溶液的液体混合物在加入d-葡萄糖酸-δ-内酯（GDL）后通过聚电解质络合形成凝胶，GDL缓慢水解并提供质子。 [43]
Interfacial Polyelectrolyte Complexation
Inspired by muscle architectures, double network hydrogels with hierarchically aligned structures were fabricated, where cross-linked cellulose nanofiber (CNF)/chitosan hydrogel threads obtained by interfacial polyelectrolyte complexation spinning were collected in alignment as the first network, while isotropic poly(acrylamide-co-acrylic acid) (PAM-AA) served as the second network. [1] Herein, chromatin-inspired supramolecular fibers formed through the interfacial polyelectrolyte complexation (IPC) process by DNA and histone proteins for encapsulation and in situ differentiation of murine brain-derived neural stem cells (NSCs) are reported. [2]受肌肉结构的启发，制备了具有分层排列结构的双网络水凝胶，其中通过界面聚电解质络合纺丝获得的交联纤维素纳米纤维（CNF）/壳聚糖水凝胶线作为第一个网络排列，而各向同性聚（丙烯酰胺-co -丙烯酸）（PAM-AA）作为第二个网络。 [1] 本文报道了由 DNA 和组蛋白通过界面聚电解质络合 (IPC) 过程形成的染色质启发的超分子纤维，用于小鼠脑源性神经干细胞 (NSC) 的封装和原位分化。 [2]
polyelectrolyte complexation method
Nanogels were prepared in aqueous media without the use of any organic solvent via a simple polyelectrolyte complexation method between aminated pullulan and fucoidan followed by covalent crosslinking with genipin. [1] Nanoplexes were formulated by the self‐assembling amphiphile polyelectrolyte complexation method and characterized. [2] Chitosan coated PLGA nanoparticles (CsPNP) were prepared by polyelectrolyte complexation method and it was further conjugated with Folic acid. [3]通过胺化支链淀粉和岩藻依聚糖之间的简单聚电解质络合方法，然后与京尼平共价交联，在不使用任何有机溶剂的水性介质中制备纳米凝胶。 [1] 通过自组装两亲聚电解质络合方法制备纳米复合物并进行表征。 [2] 采用聚电解质络合法制备壳聚糖包覆的PLGA纳米粒子（CsPNP），并进一步与叶酸共轭。 [3]