Polarized Toward(两极分化)研究综述
Polarized Toward 两极分化 - The HMS fusion protein elicited a high specific IgG level and also induced a higher level of Th1, Th2, and Th17-related cytokines which were more polarized towards the Th1 and Th17 compared to individual antigens. [1] Monocytes from Western diet consumers were polarized toward a more proinflammatory phenotype. [2] The Laplacian of the electron density in a plane of the alloy indicates that Ti atoms are polarized towards the Al-atoms thereby transferring most of their valence electron density to Al (Figure 2b). [3] Under the influence of transforming growth factor beta (TGFB), GAMs are polarized toward a tumor-supportive phenotype. [4] Moreover, macrophages were polarized toward the M2 phenotypes in IS-low/SS-high patients (P < 0. [5] Results: HIV-1-infected infants had higher frequencies of cTfh cells than HEU infants up to 12 weeks of age and these cTfh cells were polarized toward the Tfh1 subset. [6] An integrated computational study of model structure 1 in the gas phase demonstrates that the Cu–Ncyanamide and Cu–Nsac coordination bonds exhibited a single bond character, polarized toward the N atom and almost purely electrostatic, with the calculated vertical total energies for the Cu–Ncyanamide and Cu–Nsac of 43. [7] She1 does so by attenuating the initiation of dynein-mediated spindle movements specifically within the mother cell, ensuring such movements are polarized toward the daughter cell. [8] Cytotoxic granules converge at the microtubule organizing center and are polarized toward the immunological synapse (IS), followed by granule exocytosis. [9] In women with endometriosis, peritoneal macrophages were polarized towards the M1 phenotype. [10] To assess whether the TAM phenotype is shaped by secreted factors produced by tumour cells, primary human monocyte-derived macrophages were polarized towards a TAM-like phenotype using tumour cell-conditioned medium. [11] Their discussion is polarized towards content concerning Steem, Steemit, witnesses, and other platforms hosted on Steem. [12] We found that macrophages from COPD subjects were polarized towards an M1 phenotype with increased S1PR1 and decreased HADC1experssion. [13] This represents a distinct directionality for the development of cytoplasmic polarity and discarding of residual body compared with that reported for vertebrates (in which the cytoplasm of the elongating spermatids is polarized toward the caudal region). [14] Lung interstitial macrophages (IMs) can be polarized towards an alternative activation phenotype in ovalbumin (OVA)-induced asthmatic mice. [15] RESULTS BMMs from HFD-fed mice were polarized towards M1, and miR-143-5p was significantly upregulated in exosomes of BMMs from HFD-fed mice. [16] Microglia are polarized toward the proinflammatory M1 phenotype and neuroprotective M2 phenotype after stroke and play an important role in the pathological process of ischemic stroke. [17] 3 Thus, the attention of the diabetes community is being repolarized towards HF as a major focus of cardiovascular prevention. [18] In conclusion, this work reveals that autophagy organelles are polarized toward the cell front during migration and that their spatial-temporal dynamics are altered in motile cancer cells that express an oncogenic Ras protein. [19] TAM are polarized towards form M1, with a pro-inflammatory phenotype and an antineoplastic activity, or M2, with an alternately activated phenotype, associated with a poor outcome in patients presenting with leukemia, lymphoma or multiple myeloma. [20] Macrophages are ubiquitous and polarized toward a protumoral phenotype. [21] A common pathophysiological pathway could involve T follicular helper (Tfh) cells, which were shown to have increased in both diseases and polarized towards the Tfh-2 subtype, enhancing IgG4-plasma cell polarization [7, 8]. [22] Furthermore, by comparing the spike-triggered average membrane potentials, we found that dMSNs depolarized towards the spike threshold significantly faster than iMSNs did. [23] A mixed-methods approach revealed that participants' opinions were polarized towards the two display configurations, regardless of the spatial distribution of collaboration. [24] Recent studies revealed that macrophages are polarized towards the M2 phenotype in an ovalbumin (OVA)-induced asthmatic model. [25] Although skin lesions tended to be polarized toward the M2 phenotype by anti-TNF-a therapy, some triggering factors, such as paradoxical side-effects of anti-TNF-a therapy, might have induced marked inflammatory responses by M1 macrophages that subsequently overcame anti-inflammatory responses by M2 macrophages in our case. [26] Our studies demonstrate that there is an overall lower number of macrophage populations in the caruncle of cows with RET placenta and these are polarized towards M2 phenotype. [27] Macrophages were polarized toward a pro-regenerative phenotype, and the material facilitated adipose soft tissue defect repair in a rabbit model. [28] Th cell differentiation was polarized toward the upregulation of regulatory T cells (Tregs) and the downregulation of Th17 in PIAS3-treated mice. [29] The Arg I/iNOS ratio and TIMP1/MMP12 ratio were significantly decreased in LPS- or LPS+IFNγ-treated PAM and IM, suggesting that cells were polarized towards M1 macrophages under LPS or LPS+IFNγ stimulation. [30] Bimolecular fluorescence complementation and deep mutational scanning reveal that TAPBPR recognition is polarized toward the α2 domain of the peptide-binding groove, and depends on the formation of a conserved MHC-I disulfide epitope in the α2 domain. [31] Macrophages can be polarized towards the anti- (M2), leading to the production of immunosuppressive factors IL-10 and ARG1 or via iNOS stimulation, pro-(M1) inflammatory subtype. [32] Certain CD4+T cell subsets, especially those polarized toward the T helper (Th) subsets Th1 andTh17, have been shown to be major drivers of inflammation in patients with RA. [33] First of all, we prove that when the initial network opinions are polarized towards one side of the state space, node biases will drive the opinion evolution to the corresponding interval boundaries. [34] Macrophages can be polarized towards either a classically activated pro-inflammatory (M1) state, or alternatively towards an activated anti-inflammatory (M2) state. [35] HPV-positive TC-1 and C3 tumors of immunized mice are heavily infiltrated with activated immune cells and HPV16-specific T cells and are polarized towards a proinflammatory, cytotoxic and less immune-suppressive contexture. [36] While responses in allergics were polarized towards IL-5 production and associated with low IFNγ production, ENA responses were not polarized. [37] Conclusion TAMs were polarized towards an M2-like phenotype and CD8+ T cells density decreased in metastatic lesion of PBRM1 protein expression-negative ccRCC. [38] Here, we observed that iron‐load macrophages were polarized toward a proinflammatory macrophage phenotype. [39] Flow cytometric analyses of lung-recovered cells further revealed that pulmonary macrophages (MΦ) were polarized toward an M1-like phenotype (CD80+CD64+CD11b+Ly6G-) during the onset of disease and prior to host death, which correlated with the significant loss of CD31+CD45- ECs and M2-like (CD206+CD64+CD11b+Ly6G-) cells. [40] Macrophages co-cultured with versican-deficient mesothelioma cells were polarized towards M1 anti-tumor phenotype and demonstrated increased tumor cell phagocytic capacity, compared to macrophages co-cultured with control tumor cells. [41] The majority of macrophages were polarized towards wound healing and tumor promotion M2-type. [42] Analysis of tumor composition by flow cytometry showed that tumor‐associated macrophages (TAMs) were decreased, more polarized toward an M1‐like phenotype, and had reduced PD‐L1 expression. [43] This work is about checking the weigh to feach of these forces in this set of stories, to stop in some more polarized towards one of the two. [44] Bimolecular fluorescence complementation and deep mutational scanning reveal that TAPBPR recognition is polarized towards one side of the peptide-binding groove, and depends on the formation of a conserved MHC-I disulfide epitope in the α2 domain. [45] The Mulliken population and NBO analysis indicated that for both ligands (TBP and DBPP) the electronic charge is more polarized towards the oxygen atom of P = O group. [46] Analysis of tumor composition by flow cytometry showed that tumor associated macrophages were decreased, more polarized toward an M1-like phenotype, and had attenuated PD-L1 expression. [47] Tumors of SC1-treated mice have brisk immune cell infiltrates and are polarized towards a Th1 type signature. [48] Furthermore, by comparing the spike-triggered average membrane potentials, we found that dMSNs depolarized towards the spike threshold significantly faster than iMSNs did. [49] (2019) shows how actin waves on the ventral membrane of Dictyostelium cells propagate by de novo nucleation of oblique filaments that are polarized toward the ventral membrane without a preference to the wave direction. [50]HMS 融合蛋白引发了高特异性 IgG 水平，还诱导了更高水平的 Th1、Th2 和 Th17 相关细胞因子，与单个抗原相比，这些细胞因子更偏向 Th1 和 Th17。 [1] 来自西方饮食消费者的单核细胞趋向于更促炎的表型。 [2] 合金平面中电子密度的拉普拉斯算子表明 Ti 原子向 Al 原子极化，从而将它们的大部分价电子密度转移到 Al（图 2b）。 [3] 在转化生长因子 β (TGFB) 的影响下，GAM 被极化为支持肿瘤的表型。 [4] 此外，巨噬细胞在 IS-low/SS-high 患者中向 M2 表型极化（P < 0. [5] 结果：HIV-1 感染婴儿的 cTfh 细胞频率高于 12 周大的 HEU 婴儿，并且这些 cTfh 细胞向 Tfh1 亚群极化。 [6] 气相中模型结构 1 的综合计算研究表明，Cu-Ncyanamide 和 Cu-Nsac 配位键表现出单键特性，向 N 原子极化并且几乎是纯静电的，计算出的 Cu-氨基氰和 Cu-Nsac 为 43。 [7] She1 通过减弱动力蛋白介导的纺锤体运动的启动来实现这一点，特别是在母细胞内，确保这些运动向子细胞极化。 [8] 细胞毒性颗粒会聚在微管组织中心并极化向免疫突触 (IS)，然后是颗粒胞吐作用。 [9] 在患有子宫内膜异位症的女性中，腹腔巨噬细胞向 M1 表型极化。 [10] 为了评估 TAM 表型是否由肿瘤细胞产生的分泌因子形成，使用肿瘤细胞条件培养基将原代人单核细胞衍生的巨噬细胞极化为 TAM 样表型。 [11] 他们的讨论偏向于有关 Steem、Steemit、证人以及 Steem 上托管的其他平台的内容。 [12] 我们发现 COPD 受试者的巨噬细胞极化为 M1 表型，S1PR1 增加，HADC1 表达减少。 [13] 与脊椎动物报告的情况相比，这代表了细胞质极性发展和丢弃残留体的明显方向性（其中伸长的精子细胞的细胞质被极化向尾部区域）。 [14] 在卵清蛋白 (OVA) 诱导的哮喘小鼠中，肺间质巨噬细胞 (IM) 可以极化为另一种激活表型。 [15] 结果 来自 HFD 喂养小鼠的 BMM 向 M1 极化，并且 miR-143-5p 在来自 HFD 喂养小鼠的 BMM 外泌体中显着上调。 [16] 小胶质细胞在卒中后向促炎性 M1 表型和神经保护性 M2 表型极化，在缺血性卒中的病理过程中起重要作用。 [17] 3 因此，糖尿病社区的注意力正在重新转向将 HF 作为心血管预防的主要焦点。 [18] 总之，这项工作揭示了自噬细胞器在迁移过程中向细胞前沿极化，并且它们的时空动力学在表达致癌 Ras 蛋白的运动癌细胞中发生了改变。 [19] TAM 偏向于 M1 型，具有促炎表型和抗肿瘤活性，或 M2 型，具有交替激活的表型，与白血病、淋巴瘤或多发性骨髓瘤患者的不良预后相关。 [20] 巨噬细胞无处不在，并且两极分化为前肿瘤表型。 [21] 一个常见的病理生理途径可能涉及 T 滤泡辅助 (Tfh) 细胞，这些细胞在两种疾病中均显示增加，并极化为 Tfh-2 亚型，从而增强 IgG4 浆细胞极化 [7, 8]。 [22] 此外，通过比较尖峰触发的平均膜电位，我们发现 dMSN 向尖峰阈值去极化的速度明显快于 iMSN。 [23] 混合方法方法表明，无论协作的空间分布如何，参与者的意见都偏向于两种显示配置。 [24] 最近的研究表明，在卵清蛋白 (OVA) 诱导的哮喘模型中，巨噬细胞向 M2 表型极化。 [25] 尽管通过抗 TNF-a 治疗，皮肤损伤倾向于向 M2 表型极化，但一些触发因素，例如抗 TNF-a 治疗的反常副作用，可能已引起 M1 巨噬细胞显着的炎症反应，随后克服了抗 TNF-a 治疗。 -在我们的案例中，M2 巨噬细胞的炎症反应。 [26] 我们的研究表明，具有 RET 胎盘的奶牛肉瘤中的巨噬细胞总体数量较少，并且这些都向 M2 表型极化。 [27] 巨噬细胞被极化为促再生表型，并且该材料促进了兔模型中的脂肪软组织缺损修复。 [28] 在 PIAS3 处理的小鼠中，Th 细胞分化倾向于调节性 T 细胞 (Tregs) 的上调和 Th17 的下调。 [29] 在 LPS 或 LPS+IFNγ 处理的 PAM 和 IM 中，Arg I/iNOS 比率和 TIMP1/MMP12 比率显着降低，表明细胞在 LPS 或 LPS+IFNγ 刺激下向 M1 巨噬细胞极化。 [30] 双分子荧光互补和深度突变扫描表明 TAPBPR 识别是向肽结合沟的 α2 结构域极化的，并且取决于在 α2 结构域中形成保守的 MHC-I 二硫键表位。 [31] 巨噬细胞可以向抗 (M2) 极化，导致产生免疫抑制因子 IL-10 和 ARG1 或通过 iNOS 刺激，促 (M1) 炎症亚型。 [32] 某些 CD4+T 细胞亚群，尤其是偏向 T 辅助 (Th) 亚群 Th1 和 Th17 的那些，已被证明是 RA 患者炎症的主要驱动因素。 [33] 首先，我们证明当初始网络意见向状态空间的一侧极化时，节点偏差将推动意见演化到相应的区间边界。 [34] 巨噬细胞可以极化为经典激活的促炎 (M1) 状态，或者极化为激活的抗炎 (M2) 状态。 [35] 免疫小鼠的 HPV 阳性 TC-1 和 C3 肿瘤被激活的免疫细胞和 HPV16 特异性 T 细胞大量浸润，并极化为促炎、细胞毒性和免疫抑制较少的环境。 [36] 虽然过敏反应偏向于 IL-5 的产生并与低 IFNγ 产生相关，但 ENA 反应没有两极分化。 [37] 结论 PBRM1蛋白表达阴性ccRCC转移病灶中TAMs偏向M2样表型，CD8+ T细胞密度降低。 [38]