Novel Viral(新型病毒)研究综述
Novel Viral 新型病毒 - Nanoparticles consisting of viral-like particles (VLPs) derived from human papilloma virus capsid proteins L1 and L2 conjugated to a phthalocyanine-based photosensitizer, IRDye®700DX, have been developed as AU-011, a novel viral-like particle bioconjugate (VPB). [1] In this study, we developed a novel viral-specific drug delivery method. [2]由源自人乳头瘤病毒衣壳蛋白 L1 和 L2 的病毒样颗粒 (VLP) 组成的纳米颗粒与基于酞菁的光敏剂 IRDye®700DX 偶联，已开发为 AU-011，一种新型病毒样颗粒生物偶联物 (VPB) . [1] 在这项研究中，我们开发了一种新的病毒特异性药物递送方法。 [2]
severe acute respiratory 严重急性呼吸道
Severe acute respiratory coronavirus-2 (SARS-CoV-2) is a novel viral pathogen and therefore a challenge to accurately diagnose infection. [1] ABSTRACT Introduction: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged as a novel viral agent that quickly spread worldwide. [2] COVID-19 is a novel viral infection caused by severe acute respiratory syndrome (SARS) beta-coronavirus. [3] A novel viral respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-C0V-2), is responsible for a pandemic situation in the world. [4] Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a novel viral agent that can cause a life-threatening respiratory disorder named coronavirus disease 2019 (COVID‑19). [5] The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has emphasized the vulnerability of human populations to novel viral pressures, despite the vast array of epidemiological and biomedical tools now available. [6]严重急性呼吸道冠状病毒 2 (SARS-CoV-2) 是一种新型病毒病原体，因此准确诊断感染是一项挑战。 [1] 摘要 简介：严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）作为一种新型病毒剂出现，迅速在全球传播。 [2] COVID-19 是一种由严重急性呼吸综合征 (SARS) β 冠状病毒引起的新型病毒感染。 [3] 一种由严重急性呼吸综合征冠状病毒 2 (SARS-C0V-2) 引起的新型病毒性呼吸道疾病，是造成世界大流行的原因。 [4] nan [5] nan [6]
coronavirus disease 2019 2019冠状病毒病
SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). [1] Coronavirus disease 2019 (COVID-19) is novel viral disease caused by SARS-CoV-2. [2] Aims Coronavirus disease 2019 (COVID-19) is a novel viral infection threatening worldwide health as currently there exists no effective treatment strategy and vaccination programs are not publicly available yet. [3] Introduction: Coronavirus disease 2019 (COVID-19) pandemic, being a novel viral infection, has resulted in disruption of health services, including cancer patient's care and treatment. [4] Human contamination by the novel viral microbe SARS-CoV-2 outcomes in a clinical condition named Coronavirus Disease 2019 (COVID-19). [5] The coronavirus disease 2019 (COVID-19) is heterogeneous and our understanding of the biological mechanisms of host response to the novel viral infection remains limited. [6]SARS 冠状病毒 2 (SARS-CoV-2) 是一种新型病毒病原体，可导致称为 2019 年冠状病毒病 (COVID-19) 的临床疾病。 [1] 2019 年冠状病毒病 (COVID-19) 是由 SARS-CoV-2 引起的新型病毒性疾病。 [2] 目标 2019 年冠状病毒病 (COVID-19) 是一种威胁全球健康的新型病毒感染，因为目前尚无有效的治疗策略，疫苗接种计划尚未公开。 [3] nan [4] nan [5] nan [6]
Identifying Novel Viral 识别新型病毒
Our findings demonstrate the reusability of public sequencing data for surveying viral infections and identifying novel viral sequences, presenting a warning about a new threat of viral infectious disease to public health. [1] Our findings demonstrate the reusability of public sequencing data for surveying viral infections and identifying novel viral sequences, presenting a warning about a new threat of viral infectious disease to public health. [2] Virome-wide analysis is necessary for identifying novel viral etiologies. [3]我们的研究结果证明了公共测序数据在调查病毒感染和识别新病毒序列方面的可重用性，对病毒传染病对公共卫生的新威胁提出了警告。 [1] 我们的研究结果证明了公共测序数据在调查病毒感染和识别新病毒序列方面的可重用性，对病毒传染病对公共卫生的新威胁提出了警告。 [2] 病毒组范围的分析对于识别新的病毒病因是必要的。 [3]
20 Novel Viral
Based on phylogenetic topology and the availability of coding-complete genomes we estimate that at least 20 novel viral genera in seven families need to be defined, only two of them monospecific. [1] The canonical viral early and late RNA cassettes were confirmed, but analysis of splice junctions within long RNA reads revealed an additional 20 novel viral transcripts. [2]基于系统发育拓扑和编码完整基因组的可用性，我们估计需要定义七个科中至少 20 个新病毒属，其中只有两个是单特异性的。 [1] 确认了规范的病毒早期和晚期 RNA 盒，但对长 RNA 读数内的剪接点的分析揭示了另外 20 个新的病毒转录物。 [2]
Three Novel Viral
Among the sequences were three novel viral variants: BV-1 with a B. [1] We report three novel viral proteins potentially involved in regulating the host type I interferon response. [2]这些序列中有三个新的病毒变体：BV-1 和 B. [1] 我们报告了三种可能参与调节宿主 I 型干扰素反应的新型病毒蛋白。 [2]
Identified Novel Viral
Coronavirus disease of 2019 (COVID-19) is an extremely communicable disease characterized by the serious acute respiratory influenza virus 2, a recently identified novel viral disease (SARS-CoV-2). [1] We identified novel viral integrations in both genomes. [2]2019 年冠状病毒病 (COVID-19) 是一种传染性极强的疾病，其特征是严重的急性呼吸道流感病毒 2，这是一种最近发现的新型病毒性疾病 (SARS-CoV-2)。 [1] 我们在两个基因组中发现了新的病毒整合。 [2]
Developing Novel Viral
Furthermore, future perspectives are discussed for further developing novel viral nanocarriers or improving existing viral vectors. [1] miR‑217 and miR‑543 may be potential therapeutic targets for developing novel viral myocarditis treatments in the future. [2]nan [1] miR‑217 和 miR‑543 可能是未来开发新型病毒性心肌炎治疗的潜在治疗靶点。 [2]
Putative Novel Viral 推定的新型病毒
A total of seven viruses, including six putative novel viral entities, were identified. [1] Ninety-two mycoviruses were identified: 62 new mycoviral species constituting putative novel viral genera and families. [2]共鉴定出七种病毒，包括六种推定的新型病毒实体。 [1] 鉴定出 92 种真菌病毒：62 种新的真菌病毒，构成推定的新型病毒属和科。 [2]
novel viral infection 新型病毒感染
Aims Coronavirus disease 2019 (COVID-19) is a novel viral infection threatening worldwide health as currently there exists no effective treatment strategy and vaccination programs are not publicly available yet. [1] COVID-19 is a novel viral infection caused by severe acute respiratory syndrome (SARS) beta-coronavirus. [2] This novel viral infection demonstrated unique features that include prothrombotic clinical presentations. [3] Introduction: Coronavirus disease 2019 (COVID-19) pandemic, being a novel viral infection, has resulted in disruption of health services, including cancer patient's care and treatment. [4] COVID-19 is a novel viral infection that primarily affects the lungs and runs the gamut from a mild, self-limiting, febrile illness to respiratory failure and death. [5] The emergence of novel viral infections of zoonotic origin and mutations of existing human pathogenic viruses represent a serious concern for public health. [6] Development of antiviral agents is crucial to combat both existing and novel viral infections. [7] Emergency departments (EDs) are the point of entry for infectious diseases, making it necessary to reevaluate current practices and make adjustments to decrease transmission when presented with a novel viral infection. [8] The coronavirus disease 2019 (COVID-19) is heterogeneous and our understanding of the biological mechanisms of host response to the novel viral infection remains limited. [9] CoVID-19 is a novel viral infection with now well-established clinical radiological findings. [10] Social distancing is an effective measure to mitigate the spread of novel viral infections in the absence of antiviral agents and insufficient vaccine supplies. [11] Regardless of whether these neurological symptoms are direct or indirect casual infection relationship, this novel viral infection has a relevant impact on the neuroimmune system that requires a neurologist’s careful assessment. [12] COVID-19 is a multisystem Novel viral infection with protean manifestations and variable degrees of clinical presentation. [13]目标 2019 年冠状病毒病 (COVID-19) 是一种威胁全球健康的新型病毒感染，因为目前尚无有效的治疗策略，疫苗接种计划尚未公开。 [1] COVID-19 是一种由严重急性呼吸综合征 (SARS) β 冠状病毒引起的新型病毒感染。 [2] 这种新型病毒感染表现出独特的特征，包括血栓形成前的临床表现。 [3] nan [4] COVID-19 是一种新型病毒感染，主要影响肺部，范围从轻度、自限性、发热性疾病到呼吸衰竭和死亡。 [5] 人畜共患起源的新型病毒感染的出现和现有人类致病病毒的突变代表了对公共卫生的严重关注。 [6] 抗病毒药物的开发对于对抗现有和新型病毒感染至关重要。 [7] 急诊科 (ED) 是传染病的切入点，因此有必要重新评估当前的做法并进行调整以在出现新型病毒感染时减少传播。 [8] nan [9] nan [10] nan [11] nan [12] nan [13]
novel viral variant 新型病毒变体
To the extent that luck plays a role in favoring the emergence of novel viral variants with an evolutionary advantage, targeting these low-probability random events might allow us to tip the balance of fortune away from these advantageous variants and prevent them from being established in the population. [1] ‘The nature and duration of immunity in these cohorts will be critical to understand as the COVID-19 pandemic progresses, particularly with respect to the efficacy of vaccination strategies -single-dose, multipledoses, vaccine combinations – and in relation to novel viral variants of concern. [2] Background: Oncological patients have a higher risk of prolonged SARS-CoV-2 shedding, which, in turn, can lead to evolutionary mutations and emergence of novel viral variants. [3] ‘The nature and duration of immunity in these cohorts will be critical to understand as the COVID-19 pandemic progresses, particularly with respect to the efficacy of vaccination strategies – single-dose, multiple-doses, vaccine combinations and in relation to novel viral variants of concern. [4] Genomic surveillance can lead to early identification of novel viral variants and inform pandemic response. [5] Hospitalized patients with a compromised immune system may be a potential source of novel viral variants, which calls for monitoring viral evolution by genome sequencing in clinical settings. [6] Surveillance on the HIV molecular variability, risk of drug resistance transmission and evolution of novel viral variants among blood donors remains an understudied aspect of hemovigilance. [7] The failure of public health measures to contain the spread of the disease in many countries has given rise to novel viral variants with increased transmissibility. [8] Among the sequences were three novel viral variants: BV-1 with a B. [9] We discovered novel viral variants strongly associated with viral load and HBeAg status. [10] The findings reported in this paper highlight the importance of continuously monitoring the RVA strains circulating in paediatric age in order to detect novel viral variants able to spread in the general population. [11]在某种程度上，运气在促进具有进化优势的新型病毒变体的出现方面发挥了作用，针对这些低概率随机事件可能会让我们摆脱这些有利变体的命运平衡，并阻止它们在人口。 [1] “随着 COVID-19 大流行的发展，这些群体中免疫的性质和持续时间对于理解这一点至关重要，特别是在疫苗接种策略的有效性方面——单剂量、多剂量、疫苗组合——以及与新型病毒变体有关关心。 [2] 背景：肿瘤患者的 SARS-CoV-2 长期脱落风险更高，这反过来又会导致进化突变和新病毒变体的出现。 [3] “随着 COVID-19 大流行的发展，这些人群中免疫的性质和持续时间对于理解这一点至关重要，特别是在疫苗接种策略的有效性方面——单剂量、多剂量、疫苗组合以及与新型病毒变体有关关注。 [4] nan [5] nan [6] nan [7] nan [8] 这些序列中有三个新的病毒变体：BV-1 和 B. [9] 我们发现了与病毒载量和 HBeAg 状态密切相关的新型病毒变体。 [10] 本文报告的研究结果强调了持续监测儿科流行的 RVA 毒株以检测能够在普通人群中传播的新型病毒变体的重要性。 [11]
novel viral pathogen 新型病毒病原体
Severe acute respiratory coronavirus-2 (SARS-CoV-2) is a novel viral pathogen and therefore a challenge to accurately diagnose infection. [1] SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical disease called coronavirus disease 2019 (COVID-19). [2] Additionally, we emphasized the potential of applying the quantitative microbial risk assessment to guide drinking water treatment to mitigate the viral exposure risks, especially when the unregulated novel viral pathogens are of concern. [3] Background To develop an effective vaccine against a novel viral pathogen, it is important to understand the longitudinal antibody responses against its first infection. [4] In the current absence of a vaccine, herd immunity remains the only way to stabilise human population reaction to the novel viral pathogen. [5] This study provides the first insight into the ecology and micro-evolutionary dynamics of this novel viral pathogen in the captive exotic squirrel population under artificial ecological conditions (zoos and animal husbandry) and co-housing of different squirrel species. [6] Michigan's experience holds sobering lessons for those who wish to understand how immunologically naïve populations encounter novel viral pathogens. [7] Obesity and related inflammation, and yet paradoxical suppression of the innate immune response within the pulmonary compartment are important determinants in the host response to a novel viral pathogen(21). [8] In this study we report the development of a novel viral pathogen immunosensor technology based on the electrochemical modulation of the optical signal from a surface plasmon wave interacting with a redox dye reporter. [9] ABSTRACT To counteract the serious health threat posed by known and novel viral pathogens, drugs that target a variety of viruses through a common mechanism have attracted recent attention due to their potential in treating (re)emerging infections, for which direct-acting antivirals are not available. [10]严重急性呼吸道冠状病毒 2 (SARS-CoV-2) 是一种新型病毒病原体，因此准确诊断感染是一项挑战。 [1] SARS 冠状病毒 2 (SARS-CoV-2) 是一种新型病毒病原体，可导致称为 2019 年冠状病毒病 (COVID-19) 的临床疾病。 [2] nan [3] 背景 为了开发针对新型病毒病原体的有效疫苗，了解针对其首次感染的纵向抗体反应非常重要。 [4] 在目前没有疫苗的情况下，群体免疫仍然是稳定人群对新型病毒病原体反应的唯一方法。 [5] nan [6] nan [7] nan [8] 在这项研究中，我们报告了一种新型病毒病原体免疫传感器技术的发展，该技术基于表面等离子体波与氧化还原染料报告分子相互作用的光信号的电化学调制。 [9] 摘要：为了应对已知和新型病毒病原体对健康造成的严重威胁，通过共同机制靶向多种病毒的药物因其在治疗（重新）新发感染方面的潜力而引起了最近的关注，而直接作用的抗病毒药物则不能。可用的。 [10]
novel viral disease 新型病毒性疾病
Background: At the end of 2019, a novel viral disease COVID 19 has devastated the world. [1] Background and purpose COVID-19 is a novel viral disease causing worldwide pandemia. [2] Coronavirus disease 2019 (COVID-19) is novel viral disease caused by SARS-CoV-2. [3] Readily apparent are the changes that we have made to cope with the acute needs generated by a novel viral disease, but we can only speculate on the long-term consequences these changes will bring to the approach and practice of medicine. [4] Over the last two decades, emergence of novel viral diseases such as SARS, influenza A/H1N1(09) pdm; MERS; Nipah virus disease; Ebola haemorrhagic fever and the current COVID-19 has resulted in massive outbreaks, epidemics and pandemics thereby causing profound losses of human life, health and economy. [5] (1) Background: Long COVID syndrome refers to long-term sequelae of the novel viral disease, which occur even in patients with initially mild disease courses. [6] Recent data with COVID-19 patients indicate that obesity also is a significant risk factor for this novel viral disease and poor outcome of associated critical illness. [7] COVID-19 is a novel viral disease with little known about its management. [8] Coronavirus disease of 2019 (COVID-19) is an extremely communicable disease characterized by the serious acute respiratory influenza virus 2, a recently identified novel viral disease (SARS-CoV-2). [9]背景：2019 年底，一种新型病毒性疾病 COVID 19 席卷全球。 [1] 背景和目的 COVID-19 是一种新型病毒性疾病，可导致全球大流行。 [2] 2019 年冠状病毒病 (COVID-19) 是由 SARS-CoV-2 引起的新型病毒性疾病。 [3] 显而易见的是，我们为应对一种新型病毒性疾病产生的紧急需求所做的改变，但我们只能推测这些改变将给医学方法和实践带来的长期后果。 [4] 在过去的二十年中，出现了新型病毒性疾病，例如 SARS、流感 A/H1N1(09) pdm；中东呼吸综合征；尼帕病毒病；埃博拉出血热和当前的 COVID-19 已导致大规模爆发、流行病和流行病，从而造成人类生命、健康和经济的巨大损失。 [5] (1) 背景：长期 COVID 综合征是指新型病毒性疾病的长期后遗症，即使在最初病程较轻的患者中也会发生。 [6] COVID-19 患者的最新数据表明，肥胖也是这种新型病毒性疾病和相关危重疾病预后不良的重要危险因素。 [7] nan [8] 2019 年冠状病毒病 (COVID-19) 是一种传染性极强的疾病，其特征是严重的急性呼吸道流感病毒 2，这是一种最近发现的新型病毒性疾病 (SARS-CoV-2)。 [9]
novel viral species 新型病毒种
In this period, 45 novel viral species were identified in tomato, 14 of which were discovered using high-throughput sequencing (HTS). [1] Through analysis of the sequences, we identified several unique viral sequences representing possible novel viral species. [2] Here, we profile 148 diverse wild-caught mosquitoes collected in California and detect sequences from eukaryotes, prokaryotes, 24 known and 46 novel viral species. [3] While MfuPV1, together with PVs identified in other macaques, is classified into the Alphapapillomavirus (Alpha-PV) species 12, MfuPV2 is most likely a representative of the novel viral species within the Alpha-PV genus. [4] The name "Fusarium equiseti partitivirus 1" (FePV1) is therefore suggested for this novel viral species. [5] We propose that PaV1 belongs to a novel viral species of a new, yet-to-be established family. [6] The discovered viruses, named wastewater CRESS DNA virus (WCDV)-1 to -3, represent novel viral species that seem to persist in wastewater effluent. [7]在此期间，在番茄中鉴定出 45 种新型病毒，其中 14 种是使用高通量测序 (HTS) 发现的。 [1] 通过对序列的分析，我们确定了几个独特的病毒序列，代表可能的新病毒种类。 [2] nan [3] nan [4] nan [5] 我们提出 PaV1 属于一个新的、尚未建立的家族的新病毒物种。 [6] 发现的病毒被命名为废水 CRESS DNA 病毒 (WCDV)-1 至 -3，代表了似乎持续存在于废水排放物中的新型病毒。 [7]
novel viral agent 新型病毒剂
ABSTRACT Introduction: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged as a novel viral agent that quickly spread worldwide. [1] A novel viral agent was isolated from striped snakehead (Channa striata Bloch, 1793) suffering from mortality with dermal ulcerations and haemorrhagic areas in South India. [2] COVID-19, which is a consequence of infection with the novel viral agent SARS-CoV-2, first identified in China (Hubei Province), has been declared a pandemic by the WHO. [3] Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a novel viral agent that can cause a life-threatening respiratory disorder named coronavirus disease 2019 (COVID‑19). [4] Given the high transmissibility of SARS-CoV-2, short serial intervals, and asymptomatic transmission patterns, the effectiveness of contact tracing for this novel viral agent is largely unknown. [5] Lessons learned from COVID-19 can be used to prevent pandemic threats by designing strategies to support different policy responses, not limited to the health system, directed to reduce the risks of the emergence of novel viral agents, the diffusion of infectious diseases and negative impact in society. [6] Overall, then, this study finds that an effective and proactive strategy to reduce the negative impact of future pandemics, driven by novel viral agents, has to be based on a planning of enhancement of healthcare sector and of sustainability in environment that can reduce fatality rate of infectious diseases in society. [7]摘要 简介：严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）作为一种新型病毒剂出现，迅速在全球传播。 [1] 从印度南部因皮肤溃疡和出血区域死亡的条纹蛇头 (Channa striata Bloch, 1793) 中分离出一种新型病毒剂。 [2] COVID-19 是感染新型病毒剂 SARS-CoV-2 的结果，该病毒首先在中国（湖北省）发现，已被世界卫生组织宣布为大流行病。 [3] nan [4] nan [5] nan [6] nan [7]
novel viral sequence 新型病毒序列
Our findings demonstrate the reusability of public sequencing data for surveying viral infections and identifying novel viral sequences, presenting a warning about a new threat of viral infectious disease to public health. [1] Our findings demonstrate the reusability of public sequencing data for surveying viral infections and identifying novel viral sequences, presenting a warning about a new threat of viral infectious disease to public health. [2] Finally, as the virosphere exploration unravels novel viral sequences, VirSorter2’s modular design makes it inherently able to expand to new types of viruses via the design of new classifiers to maintain maximal sensitivity and specificity. [3] Using a probe based on the novel viral sequence, DNA in situ hybridization identified viral nucleic acid in the nucleus. [4] 1% different from each other but 33% different than the novel viral sequence found in the July 2017 samples. [5] Metagenomic studies have been a rich source for discovering novel viral sequences, and in recent years have unraveled numerous ssRNA phage genomes significantly different from those known before. [6]我们的研究结果证明了公共测序数据在调查病毒感染和识别新病毒序列方面的可重用性，对病毒传染病对公共卫生的新威胁提出了警告。 [1] 我们的研究结果证明了公共测序数据在调查病毒感染和识别新病毒序列方面的可重用性，对病毒传染病对公共卫生的新威胁提出了警告。 [2] nan [3] 使用基于新病毒序列的探针，DNA 原位杂交鉴定了细胞核中的病毒核酸。 [4] 与 2017 年 7 月样本中发现的新型病毒序列相比，彼此差异 1%，但差异 33%。 [5] 宏基因组研究一直是发现新病毒序列的丰富资源，并且近年来揭示了许多与以前已知的显着不同的 ssRNA 噬菌体基因组。 [6]
novel viral genu 新型病毒属
Together, these results suggest that ZP6 could represent a novel viral genus, here named Mareflavirus. [1] To characterize the diversity and evolution of this novel viral genus, we report here on the isolation and genome sequencing of a second strain of Kaumoebavirus, namely LCC10. [2] The phylogenetic tree based on the amino acid sequences of whole genomes revealed that vB_MalS-PS3 has a distant evolutionary relationship with other siphoviruses, and can be grouped into a novel viral genus cluster with six uncultured assembled viral genomes from metagenomics, named here as Marinovirus. [3] Phages isolated in this study belong to a novel viral genus, Bacuni, within the Siphoviridae family. [4] Finally, a highly divergent picorna-like virus found in the gut of the French rabbit virus was only ~35% similar to an arilivirus at the amino acid level, suggesting the presence of a novel viral genus within the Picornaviridae. [5]总之，这些结果表明 ZP6 可能代表一种新的病毒属，这里命名为 Mareflavirus。 [1] 为了表征这种新型病毒属的多样性和进化，我们在此报告了第二株 Kaumoebavirus 的分离和基因组测序，即 LCC10。 [2] nan [3] nan [4] 最后，在法国兔病毒的肠道中发现的一种高度分化的小核糖核酸样病毒在氨基酸水平上与阿里利病毒仅 35% 相似，这表明在小核糖核酸病毒科中存在一种新的病毒属。 [5]
novel viral protein 新型病毒蛋白
However, recent data highlighted the relevance of these HBV-spliced variants through (1) the trans-regulation of the alternative splicing of viral transcripts along the course of liver disease; (2) the ability to generate defective particle formation, putative biomarker of the liver disease progression; (3) modulation of viral replication; and (4) their intrinsic propensity to encode for novel viral proteins involved in liver pathogenesis and immune response. [1] The novel viral protein spot (VIP-SPOT) assay, based on the enzyme-linked ImmunoSpot (ELISpot) approach, quantifies the frequency of CD4+ T cells that produce HIV antigen upon stimulation. [2] The Horizon2020 Virus-X project was established in 2015 to explore the virosphere of selected extreme biotopes and discover novel viral proteins. [3] We report three novel viral proteins potentially involved in regulating the host type I interferon response. [4]然而，最近的数据通过以下方式强调了这些 HBV 剪接变体的相关性：(1) 肝病过程中病毒转录物选择性剪接的反式调节； (2) 产生缺陷颗粒形成的能力，肝脏疾病进展的推定生物标志物； (3) 病毒复制的调节； (4) 它们编码与肝脏发病机制和免疫反应有关的新型病毒蛋白的内在倾向。 [1] 新型病毒蛋白斑点 (VIP-SPOT) 检测基于酶联免疫斑点 (ELISpot) 方法，可量化刺激后产生 HIV 抗原的 CD4+ T 细胞的频率。 [2] Horizon2020 Virus-X 项目成立于 2015 年，旨在探索选定的极端生物群落的病毒圈并发现新的病毒蛋白。 [3] 我们报告了三种可能参与调节宿主 I 型干扰素反应的新型病毒蛋白。 [4]
novel viral strategy 新型病毒策略
This study provides a novel viral strategy to impair MAPK activation. [1] These studies reveal a novel viral strategy in which NP releases P58IPK from its negative regulator and selectively engages it on the 40S ribosomal subunit to promptly combat the PKR antiviral responses. [2] Using a novel viral strategy for cell-type-specific and spatially restricted expression of a dominant-negative trkB (trkB. [3] Our study not only provides an important clue to understand MeV neuropathogenicity but also reveals a novel viral strategy to expand cell tropism. [4]本研究提供了一种新的病毒策略来削弱 MAPK 激活。 [1] 这些研究揭示了一种新的病毒策略，其中 NP 从其负调节剂中释放 P58IPK，并选择性地将其与 40S 核糖体亚基结合，以迅速对抗 PKR 抗病毒反应。 [2] nan [3] 我们的研究不仅为了解 MeV 神经致病性提供了重要线索，而且还揭示了一种扩大细胞嗜性的新病毒策略。 [4]
novel viral vector 新型病毒载体
Recent years have seen the development of a large number of novel viral vectors for delivering specific therapies. [1] In the present study, we utilized a novel oligotrophic AAV, Olig001, to overexpress aSyn specifically in striatal oligodendrocytes of rats and nonhuman primates in an effort to further characterize our novel viral vector-mediated MSA animal models. [2] To counter the deleterious effect of sympathetic denervation, we developed a novel viral vector (AAV9-Hand2-eGFP, Hand2) carrying Hand2 expression exclusively to sympathetic neurons. [3] In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympathetic neuronal populations involved in heart rate control in mice. [4]近年来，已经开发出大量用于提供特定疗法的新型病毒载体。 [1] 在本研究中，我们利用一种新型的寡营养 AAV，Olig001，在大鼠和非人灵长类动物的纹状体少突胶质细胞中特异性过度表达 aSyn，以进一步表征我们新型病毒载体介导的 MSA 动物模型。 [2] 为了对抗去交感神经的有害影响，我们开发了一种新的病毒载体（AAV9-Hand2-eGFP，Hand2），它专门对交感神经元进行 Hand2 表达。 [3] 在这项研究中，作者使用组织清除技术对心脏中的神经进行 3D 高分辨率表征，并使用转基因和新型病毒载体方法来识别参与小鼠心率控制的外周副交感神经和交感神经元群。 [4]
novel viral pandemic 新型病毒大流行
If we really aim to bring an end to this novel viral pandemic, we have to implement specific public health and social interventions which can either reduce or completely interrupt the probability of transmission of the disease. [1] However, the SEIR model prototype is generic and not able to capture the unique nature of a novel viral pandemic such as SARS-CoV-2. [2] COVID-19 is a novel viral pandemic. [3] We are currently experiencing a deadly novel viral pandemic with no efficacious, readily available anti-viral therapies to SARS-CoV-2. [4]如果我们真的打算结束这种新型病毒大流行，我们必须实施具体的公共卫生和社会干预措施，以减少或完全阻断疾病传播的可能性。 [1] 然而，SEIR 模型原型是通用的，无法捕捉到新型病毒大流行（如 SARS-CoV-2）的独特性。 [2] COVID-19 是一种新型的病毒性大流行病。 [3] nan [4]
novel viral strain 新型病毒株
Although several vaccines had cleared the clinical trials and are being administered in different countries, the degree of protection varies due to the emergence of novel viral strains. [1] Genetic reassortment gives rise to novel viral strains causing new outbreaks with epidemic or pandemic potential against which mankind is not prepared to fight. [2] Field studies from areas of endemic FMD suggest that animals can be simultaneously infected by more than one distinct variant of FMD virus (FMDV), potentially resulting in emergence of novel viral strains through recombination. [3] The emergence of highly transmissible novel viral strains that escape neutralizing responses emphasizes the urgent need to deepen our understanding of SARS-CoV-2 biology and to develop additional therapeutic strategies. [4]尽管有几种疫苗已通过临床试验并在不同国家进行管理，但由于新病毒株的出现，保护程度有所不同。 [1] 基因重组产生了新的病毒株，引起了具有流行或大流行潜力的新爆发，人类还没有准备好与之抗争。 [2] nan [3] nan [4]
novel viral cluster 新型病毒簇
Conclusions These results describe the first Oceanospirillum phage, vB_OliS_GJ44, that represents a novel viral cluster and exhibits interesting genetic features related to phage–host interactions and evolution. [1] It was also distinctive in community structure and had many novel viral clusters not associated with the other habitual virome included in our analyses. [2] In a viromics approach, we discover 491 novel viral clusters and show that sponges, as filter-feeding organisms, are distinct viral niches. [3]结论 这些结果描述了第一个 Oceanospirillum 噬菌体 vB_OliS_GJ44，它代表了一个新的病毒簇，并表现出与噬菌体-宿主相互作用和进化相关的有趣遗传特征。 [1] 它的群落结构也很独特，并且有许多与我们分析中包含的其他习惯性病毒组无关的新病毒簇。 [2] 在病毒学方法中，我们发现了 491 个新的病毒簇，并表明海绵作为滤食性生物，是不同的病毒生态位。 [3]
novel viral characteristic
Our study reports the emergence of a new reassortant of zoonotic A(H7N4) AIVs with novel viral characteristics and emphasizes the need for ongoing surveillance of avian-origin A(H7Nx) viruses. [1] Our study reports the emergence of a new reassortant of zoonotic H7N9 AIVs with novel viral characteristics and warns of the challenge we still face to control the zoonotic H7N9 AIVs and their reassortants. [2] Our study reports the emergence of a new reassortant of H7N2 AIV with novel viral characteristics and warns of the challenge we still face to control the zoonotic H7N9 AIVs and their reassortants. [3]我们的研究报告了具有新病毒特征的人畜共患病 A(H7N4) AIV 的新重组体的出现，并强调需要持续监测禽源 A(H7Nx) 病毒。 [1] 我们的研究报告了具有新病毒特征的人畜共患病 H7N9 AIV 的新重组体的出现，并警告我们在控制人畜共患病 H7N9 AIV 及其重组体方面仍面临挑战。 [2] 我们的研究报告了具有新病毒特征的 H7N2 AIV 新重配体的出现，并警告我们在控制人畜共患 H7N9 AIV 及其重配体方面仍面临挑战。 [3]
novel viral genome 新型病毒基因组
Novel viral genome prediction is crucial for understanding the complex viral diseases like AIDS and Ebola. [1] Here, we report 2,416 novel viral genomes from the SO, obtained from newly sequenced viral metagenomes in combination with mining of publicly available data sets, which represents a 25% increase in the SO viral genomes reported to date. [2] Additionally, the approach led to the discovery of several potentially novel viral genomes that bear no similarity to sequences in the public databases. [3]新的病毒基因组预测对于理解复杂的病毒性疾病如艾滋病和埃博拉病毒至关重要。 [1] 在这里，我们报告了来自 SO 的 2,416 个新病毒基因组，这些基因组来自新测序的病毒宏基因组，并结合对公开可用数据集的挖掘，这代表迄今为止报告的 SO 病毒基因组增加了 25%。 [2] nan [3]