Novel Hepatoprotective(新型保肝药)研究综述
Novel Hepatoprotective 新型保肝药 - Background This report represents the second part (Part 2) of a two-part report on investigating a novel hepatoprotective substance in ume extract. [1] subtilis supplementation imparts novel hepatoprotective functions by improving intestinal permeability and homeostasis. [2] The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents. [3] Therefore, ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury. [4] CONCLUSION Ginsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides. [5] Our findings indicate a novel hepatoprotective role for GsdmD in noninfectious inflammation models via regulation of caspase-8 expression and downstream cell death pathways. [6] In this pilot study, the seaweed derivative mixture can significantly reduce ALT, indicating that the combination of fucoidan and fucoxanthin might be a novel hepatoprotective supplement for NAFLD patients. [7] Here, we have identified a novel hepatoprotective brain/brown adipose tissue (BAT)/liver axis. [8] In conclusion, TELL purveyed conceivable novel hepatoprotective mechanisms and attenuated events associated with acute hepatic injury via inhibition of TLR4 downstream axis and activation of Nrf-2 and PI3K/Akt signaling cascades. [9] In conclusion, Tetracera akara extract exerted hepatoprotective effect against acute hepatotoxicity induced by carbon tetrachloride in Wistar rats, which could be due to the bioactive phytoconstituents present in the extract and these findings provide impetus for the development of a novel hepatoprotective herbal drug. [10]背景 本报告是关于研究梅子提取物中一种新型保肝物质的两部分报告的第二部分（第 2 部分）。 [1] 枯草芽孢杆菌补充剂通过改善肠道通透性和体内平衡来赋予新的保肝功能。 [2] 现有保肝药物缺乏安全性和有效性，这促使需要探索新的保肝药物。 [3] 因此，人参皂甙 Rk3 显示出作为预防药物性肝损伤的新型保肝剂的潜力。 [4] 结论 人参皂苷可逆转 LPS 诱导的肝脏 CYP3A11/3A4 功能障碍的影响，表明 CYP3A11/3A4 在受损肝脏中表达的稳定似乎是人参皂苷的一种新的保肝机制。 [5] 我们的研究结果表明 GsdmD 通过调节 caspase-8 表达和下游细胞死亡途径在非感染性炎症模型中具有新的保肝作用。 [6] 在这项初步研究中，海藻衍生物混合物可以显着降低 ALT，表明岩藻依聚糖和岩藻黄质的组合可能是 NAFLD 患者的一种新型保肝补充剂。 [7] 在这里，我们已经确定了一种新型的保肝脑/棕色脂肪组织 (BAT)/肝轴。 [8] 总之，TELL 通过抑制 TLR4 下游轴和激活 Nrf-2 和 PI3K/Akt 信号级联，提供了可以想象的新的肝保护机制和减弱与急性肝损伤相关的事件。 [9] 总之，四氯化碳提取物对四氯化碳诱导的 Wistar 大鼠急性肝毒性具有保肝作用，这可能是由于提取物中存在的生物活性植物成分，这些发现为开发新型保肝草药提供了动力。 [10]
novel hepatoprotective mechanism
CONCLUSION Ginsenosides reverse the effects of LPS-induced hepatic CYP3A11/3A4 dysfunction, suggesting that the stabilization of the CYP3A11/3A4 expression in an injured liver appears a novel hepatoprotective mechanism of ginsenosides. [1] In conclusion, TELL purveyed conceivable novel hepatoprotective mechanisms and attenuated events associated with acute hepatic injury via inhibition of TLR4 downstream axis and activation of Nrf-2 and PI3K/Akt signaling cascades. [2]结论 人参皂苷可逆转 LPS 诱导的肝脏 CYP3A11/3A4 功能障碍的影响，表明 CYP3A11/3A4 在受损肝脏中表达的稳定似乎是人参皂苷的一种新的保肝机制。 [1] 总之，TELL 通过抑制 TLR4 下游轴和激活 Nrf-2 和 PI3K/Akt 信号级联，提供了可以想象的新的肝保护机制和减弱与急性肝损伤相关的事件。 [2]
novel hepatoprotective agent 新型保肝剂
The lack of safety and efficacy of existing hepatoprotective agents urge the need to explore novel hepatoprotective agents. [1] Therefore, ginsenoside Rk3 shows potential as a novel hepatoprotective agent to prevent drug-induced liver injury. [2]现有保肝药物缺乏安全性和有效性，这促使需要探索新的保肝药物。 [1] 因此，人参皂甙 Rk3 显示出作为预防药物性肝损伤的新型保肝剂的潜力。 [2]