Molecules Derived(分子衍生)研究综述
Molecules Derived 分子衍生 - Approximately 1 month after the beginning of fermentation, the predominating obligate anaerobes were decreased, and Amphibacillus and Polygonibacillus, which can decompose macromolecules derived from wheat bran, were predominantly observed, and the transition of microbiota became slow (phase 2). [1] In this work, we used the quantum density theory (DFT), B3LYP / 6-311G (d, p) to establish a QSAR (Quantitative Structure Activity Relationships) model on a series of molecules derived from 2-thioarylalkyl-1H -Benzimidazole. [2] Phytoecdysteroids are molecules derived from sterol metabolism and found in many plants. [3] Given the great potential of this structure and the limited number of studies that focus on molecules derived from carbon 8 of the benzopyranone heterocycle, we synthesized in this project 38 coumarin derivatives by substituting carbon 8 of the benzopyran ring with some aromatic and aliphatically substituted piperidines and piperazines. [4] Only the former test for molecules derived from COVID-19 provides reliable evidence of a current active infection. [5] This article highlights the importance of traditional medicinal plants and the phytomolecules derived from them, which possess in vitro antiviral and anti-CoV properties and further explores their potential as inhibitors to molecular targets of SARS-CoV-2 that were evaluated by in silico approaches. [6] Spiro-molecules derived from the functional spirobifluorene core play important roles in the frontiers of diverse optoelectronics. [7] Background Biogenic nanoparticles possess a capping of biomolecules derived from the organism employed in the synthesis, which contributes to their stability and biological activity. [8] Bile acids (BAs) are molecules derived from cholesterol that are involved in dietary fat absorption. [9] The large HI values (>300 mg HC/g TOC) may result from selective preservation of hydrogen-rich biomolecules derived from terrestrial and coastal vegetation. [10] Similarly, RNS is a term used to collectively refer to NO and the molecules derived from this radical. [11] As a consequence, molecules derived from the ECM changes associated to cancer are released into the bloodstream, representing potential biomarkers of tumor development. [12] Results: Thus, a series of molecules derived from bis-benzimidazoles were synthesized including N-alkylated 6 and 7a-d. [13] Recent efforts have identified heterogeneous catalysts for the selective synthesis of ethers from alcohols, aldehydes, ketones, furans, esters, olefins, carboxylic acids, and other molecules derived from biomass. [14] Thus, TLRs are capable of recognizing wide-array of patterns/molecules derived from pathogens and host as well and initiating a proinflammatory immune response through the activation of NF-κB and other transcription factors causing synthesis of proinflammatory molecules. [15] Literature has described antivenom effect of molecules derived from natural sources, as plants. [16] To address this issue, we report on the latest achievements in magnetic separation technology and offer an overview of the progress of the capture and separation of biomolecules derived from biotechnology and food technology. [17] This research aims to propose a series of molecules derived from 2-naphthoic acid as a bioactive in the fight against S. [18] The use of the herbicide glyphosate in mulch-free soil generates yield losses of 29% associated with a higher incidence of pests and fungal diseases; in all treatments, no glyphosate residuality was detected in seeds; however, residuality was detected in other molecules derived from insecticides associated with the local production system. [19] N-6 polyunsaturated fatty acids (PUFA) and molecules derived from them, including linoleic acid- and arachidonic acid-derived lipid mediators, are known to have pro-inflammatory properties in the periphery; however, this has yet to be tested in the brain. [20] However, several studies suggest that other molecules derived from plant material, such as polyphenols, have an influence on the setting of the hydraulic binder as well. [21] The innate immune system has the capacity to detect ‘non-self’ molecules derived from pathogens, known as pathogen-associated molecular patterns, via pattern recognition receptors. [22] On the base of immunologic laboratory tests concerning the mechanism of the phenomenon, the idea arose whether molecules derived for certain microbial derivatives could enter the blood circulation via the damaged bowel walls in the patient with Crohn's disease and they might act as allergens. [23] CONCLUSION A novel series of molecules derived from natural product osthol were synthesized, wherein compound 28 was found to be most effective against leukemia and with 10 fold less toxicity against normal cells. [24] These responses could potentially be mitigated by synthesizing nanoparticles directly from molecules derived from the host. [25] Furthermore, this synthesis process coats the nanoparticles with biomolecules derived from the fungus, which can improve stability and may confer biological activity. [26] This has enabled many molecules derived from plant sources to be used in cancer treatment. [27] Adipokines, inflammatory factors and other molecules derived from bone marrow adipocytes may exert systematic effects. [28] Human colonic mucosa is covered with a mucus layer several hundred microns in thickness, which serves as a barrier physically separating the underlying epithelium from bacteria, and hindering the movement of molecules derived from food and microbiota. [29]发酵开始约1个月后，主要的专性厌氧菌减少，主要观察到能分解麦麸大分子的两栖菌和多杆菌，微生物群的转变变慢（阶段2）。 [1] 在这项工作中，我们使用量子密度理论（DFT），B3LYP / 6-311G（d，p）建立了一系列衍生自2-硫代芳基烷基-1H-苯并咪唑的分子的QSAR（定量结构活性关系）模型。 [2] 植物蜕皮激素是源自甾醇代谢的分子，存在于许多植物中。 [3] 鉴于这种结构的巨大潜力以及针对苯并吡喃酮杂环碳 8 衍生的分子的研究数量有限，我们在该项目中合成了 38 种香豆素衍生物，方法是用一些芳香族和脂肪族取代的哌啶取代苯并吡喃环的碳 8 和哌嗪。 [4] 只有前一种对源自 COVID-19 的分子的测试才能提供当前活动性感染的可靠证据。 [5] 本文强调了传统药用植物及其衍生的植物分子的重要性，它们具有体外抗病毒和抗 CoV 的特性，并进一步探索了它们作为 SARS-CoV-2 分子靶标抑制剂的潜力，并通过计算机方法进行了评估。 [6] 源自功能性螺二芴核心的螺分子在各种光电子学的前沿领域发挥着重要作用。 [7] 背景生物源纳米粒子具有源自合成中使用的生物体的生物分子的封端，这有助于它们的稳定性和生物活性。 [8] 胆汁酸 (BA) 是源自胆固醇的分子，参与膳食脂肪的吸收。 [9] 较大的 HI 值（>300mg HC/g TOC）可能是由于选择性保存了源自陆地和沿海植被的富氢生物分子。 [10] 同样，RNS 是一个术语，用于统称 NO 和衍生自该自由基的分子。 [11] 因此，源自与癌症相关的 ECM 变化的分子被释放到血液中，代表了肿瘤发展的潜在生物标志物。 [12] 结果：由此合成了一系列衍生自双苯并咪唑的分子，包括N-烷基化6和7a-d。 [13] 最近的努力已经确定了用于从醇、醛、酮、呋喃、酯、烯烃、羧酸和其他源自生物质的分子中选择性合成醚的多相催化剂。 [14] 因此，TLRs 也能够识别来自病原体和宿主的广泛模式/分子，并通过激活 NF-κB 和其他导致促炎分子合成的转录因子启动促炎免疫反应。 [15] 文献描述了源自天然来源的分子（如植物）的抗蛇毒血清作用。 [16] 为了解决这个问题，我们报告了磁分离技术的最新成果，并概述了生物技术和食品技术衍生的生物分子的捕获和分离进展。 [17] 本研究旨在提出一系列衍生自 2-萘甲酸的分子，作为对抗金黄色葡萄球菌的生物活性物质。 [18] 在无覆盖土壤中使用除草剂草甘膦会导致 29% 的产量损失，这与害虫和真菌病的发生率较高有关；在所有处理中，种子中均未检测到草甘膦残留；然而，在与当地生产系统相关的杀虫剂衍生的其他分子中检测到残留物。 [19] N-6 多不饱和脂肪酸 (PUFA) 及其衍生分子，包括亚油酸和花生四烯酸衍生的脂质介质，已知在外周具有促炎特性；然而，这尚未在大脑中进行测试。 [20] 然而，一些研究表明，源自植物材料的其他分子，例如多酚，也对水硬性粘合剂的凝固有影响。 [21] 先天免疫系统有能力通过模式识别受体检测源自病原体的“非自身”分子，称为病原体相关分子模式。 [22] 在有关该现象机制的免疫学实验室测试的基础上，产生了一些想法，即源自某些微生物衍生物的分子是否可以通过克罗恩病患者受损的肠壁进入血液循环，并且它们可能充当过敏原。 [23] 结论 合成了一系列源自天然产物蛇床子醇的新分子，其中发现化合物 28 对白血病最有效，对正常细胞的毒性低 10 倍。 [24] 这些反应可以通过直接从宿主衍生的分子合成纳米粒子来减轻。 [25] 此外，这种合成过程用源自真菌的生物分子包覆纳米颗粒，这可以提高稳定性并可能赋予生物活性。 [26] 这使得许多源自植物的分子能够用于癌症治疗。 [27] 源自骨髓脂肪细胞的脂肪因子、炎症因子和其他分子可能发挥系统性作用。 [28] 人体结肠粘膜上覆盖着一层数百微米厚的粘液层，它作为一个屏障，在物理上将下层上皮与细菌隔开，并阻碍来自食物和微生物群的分子的运动。 [29]
Small Molecules Derived 小分子衍生
The DEGs were imported into BioJupies to analyze to decipher COVID-19 induced biological, molecular, and cellular processes, pathways, and small molecules derived from chemical synthesis or natural sources to mimic or reverse COVID-19-specific gene signatures. [1] Although it has been investigated as a cause of neurodegenerative disease due to its neurotoxicity, whether small molecules derived from natural products attenuate these side effects remains elusive. [2] A study of the interaction between cell membranes and small molecules derived from lignin, a protective phenolic biopolymer found in vascular plants, is crucial for identifying their potential as pharmacological and toxicological agents. [3] Thus, the induction of differentiation and/or proliferation via administration of small molecules derived from natural plants can be considered as a potential approach to repair damaged neural networks. [4] The Sonochemical synthesis of a library of 3-methyleneisoindolin-1-one based novel small molecules derived from rosuvastatin designed as potential anticancer agents was undertaken. [5] Small molecules derived from natural products (microbial origin, plant-derived, or marine organisms) have been shown to have unique chemical structures and biological activities, including HIF-1 inhibition. [6] Natural small molecules derived from plants have fascinated scientists for centuries due to their practical applications in various fields, especially in nanomedicine. [7] Stachybotrys microspora triprenyl phenol (SMTP) is a large family of small molecules derived from the fungus S. [8] (Aurigene) has patented a series of peptidomimetic small molecules derived from the PD-1 protein sequence for use in targeting the interaction between PD-1 and its ligand, PD-L1. [9] Data fusion approach was investigated in the context of pKa prediction for 391 small molecules derived from a public data source as well as for 681 compounds from an internal corporate database. [10] The work presented here provides evidence that small molecules derived from nature, such as psammaplysin F, can prevent the formation of stress granules and therefore may represent a useful strategy to improving drug efficacy. [11] Metabolites are small molecules derived from biochemical processes in metabolism, and their profiling enables the analysis of physiological functions. [12] We designed and synthesized small molecules derived from a reported PfTMK inhibitor, and thoroughly characterized the synthesized compounds in terms of enzyme inhibition and binding property; we also probed for binding site of the synthesized derivatives to provide an understanding on the SAR. [13] The term metabolomics or metabonomics, “Biochemistry's new side of view,” refers to the study of small molecules derived from biochemical reactions in cells, organs, and organisms and has more recently been generalized to metabolic phenotyping. [14] Seeking ways to better deal with this challenge, the scientific community has recently devoted much attention to small molecules derived from natural products with anti-inflammatory and immunomodulatory effects. [15] In this current work, we screened for more than 14000 small molecules derived from various natural sources and they were screened against TRAF6 C-terminal trimer interaction interface to prevent the formation of the interface. [16]DEG 被导入 BioJupies 进行分析，以破译 COVID-19 诱导的生物、分子和细胞过程、途径以及源自化学合成或天然来源的小分子，以模拟或逆转 COVID-19 特异性基因特征。 [1] 尽管由于其神经毒性已被研究为神经退行性疾病的原因，但源自天然产物的小分子是否会减轻这些副作用仍然难以捉摸。 [2] 研究细胞膜与源自木质素的小分子之间的相互作用，木质素是维管植物中发现的一种保护性酚类生物聚合物，对于确定它们作为药理学和毒理学试剂的潜力至关重要。 [3] 因此，通过施用源自天然植物的小分子诱导分化和/或增殖可以被认为是修复受损神经网络的潜在方法。 [4] 进行了基于 3-methyleneisoindolin-1-one 的新型小分子文库的声化学合成，这些小分子来源于被设计为潜在抗癌剂的瑞舒伐他汀。 [5] 源自天然产物（微生物来源、植物来源或海洋生物）的小分子已被证明具有独特的化学结构和生物活性，包括 HIF-1 抑制作用。 [6] 几个世纪以来，源自植物的天然小分子因其在各个领域的实际应用，特别是在纳米医学中的实际应用而让科学家们着迷。 [7] nan [8] (Aurigene) 已为一系列源自 PD-1 蛋白序列的拟肽小分子申请了专利，用于靶向 PD-1 与其配体 PD-L1 之间的相互作用。 [9] 数据融合方法在来自公共数据源的 391 个小分子以及来自内部公司数据库的 681 个化合物的 pKa 预测的背景下进行了研究。 [10] 这里介绍的工作提供了证据，证明源自自然界的小分子，如 psammaplysin F，可以防止应力颗粒的形成，因此可能代表了提高药物疗效的有用策略。 [11] 代谢物是源自代谢生化过程的小分子，它们的分析可以分析生理功能。 [12] 我们设计并合成了源自已报道的 PfTMK 抑制剂的小分子，并在酶抑制和结合特性方面彻底表征了合成的化合物；我们还探索了合成衍生物的结合位点，以提供对 SAR 的理解。 [13] nan [14] nan [15] nan [16]
Signaling Molecules Derived 衍生的信号分子
Lysophospholipids are bioactive signaling molecules derived from cell membrane glycerophospholipids or sphingolipids and are highly regulated under normal physiological conditions. [1] Eicosanoids are lipid signaling molecules derived from the oxidation of ω-6 fatty acids, usually arachidonic acid. [2] Metabokines are signaling molecules derived from metabolism that regulate these receptors. [3] Ruminal short-chain fatty acids (SCFAs), which are the important signaling molecules derived from the rumen microbiota, regulate a variety of physiological functions of the rumen. [4] Endogenous signaling molecules derived from lipids, peptides, and DNA, are important regulators of physiological processes during pregnancy. [5] It is believed that RKN target certain signaling molecules derived from plants to locate their hosts, however currently no plant compound has been unambiguously identified as a universal RKN attractant. [6] Hydrogen polysulfides (H2Sn, n > 1) are members of reactive sulfur species (RSS) and signaling molecules derived from hydrogen sulfide (H2S). [7] Retinoids, such as all- trans-retinoic acid (ATRA), are endogenous signaling molecules derived from vitamin A that influence a variety of cellular processes through mediation of transcription events in the cell nucleus. [8] Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. [9]溶血磷脂是源自细胞膜甘油磷脂或鞘脂的生物活性信号分子，在正常生理条件下受到高度调节。 [1] 类二十烷酸是衍生自 ω-6 脂肪酸（通常是花生四烯酸）氧化的脂质信号分子。 [2] 代谢因子是来自调节这些受体的代谢的信号分子。 [3] 瘤胃短链脂肪酸（SCFAs）是来源于瘤胃微生物群的重要信号分子，调节瘤胃的多种生理功能。 [4] 源自脂质、肽和 DNA 的内源性信号分子是怀孕期间生理过程的重要调节剂。 [5] 据信，RKN 靶向源自植物的某些信号分子以定位其宿主，但目前还没有植物化合物被明确鉴定为通用 RKN 引诱剂。 [6] nan [7] nan [8] nan [9]
Bioactive Molecules Derived 衍生的生物活性分子
Various bioactive molecules derived from plants exert protective anti-oxidative and anti-inflammatory effects and serve as natural antioxidants, such as conjugated fatty acids and phenolic compounds. [1] Furthermore, CNC surface chemistry allows to further sequester and form a coating of bioactive molecules derived from PL. [2] Bioactive molecules derived from seaweed extracts are revolutionary bio-stimulants used to enhance plant growth and increase yield production. [3] In conclusion, we highlighted the pivotal role of zinc in antiviral immunity and we suggested the bioactive molecules derived from medicinal plants as a search matrix for the development of anti-SARS-CoV-2 drugs. [4] This review presents applications of bioactive molecules derived from marine algae as a potential substitute for its current applications in the cosmetic industry. [5] Bioactive molecules derived from natural products combine the ability to absorb UV light and act as antioxidants. [6] Our hypothesis is that bioactive molecules derived from these Bifidobacteria help drive these antitumor responses and could function as cancer therapeutics or adjuvants for cancer immunotherapy. [7] Bioactive molecules derived from plants, such as those present in essential oils, can be used to treat bacterial infections. [8]来自植物的各种生物活性分子发挥保护性抗氧化和抗炎作用，并作为天然抗氧化剂，如共轭脂肪酸和酚类化合物。 [1] 此外，CNC 表面化学可以进一步隔离并形成源自 PL 的生物活性分子涂层。 [2] nan [3] nan [4] nan [5] 源自天然产物的生物活性分子结合了吸收紫外线和作为抗氧化剂的能力。 [6] 我们的假设是，源自这些双歧杆菌的生物活性分子有助于驱动这些抗肿瘤反应，并可以作为癌症治疗剂或癌症免疫治疗的佐剂。 [7] 源自植物的生物活性分子，例如存在于精油中的那些，可用于治疗细菌感染。 [8]
Rna Molecules Derived 衍生的 Rna 分子
Background Accumulating evidence demonstrates that tRFs (tRNA-derived small RNA fragments) and tiRNAs (tRNA-derived stress-induced RNA), an emerging category of regulatory RNA molecules derived from transfer RNAs (tRNAs), are dysregulated in in various human cancer types and play crucial roles. [1] Bacteria use RNA molecules derived from CRISPR segments, along with a number of CRISPR-associated (Cas) enzymes, to identify foreign DNA and slice it apart. [2] Accumulating evidences demonstrate that tRFs and tiRNAs, are an emerging category of regulatory RNA molecules derived from transfer RNA (tRNA), are dysregulated in in various human cancer types and play crucial roles. [3] ABSTRACT Transfer RNA fragments (tRFs) are an emerging class of small RNA molecules derived from mature or precursor tRNAs. [4] Dear Editor, Circular RNAs (circRNAs) are covalently closed RNA molecules derived from thousands of protein-coding genes via “backsplicing”. [5] In recent years, a number of small RNA molecules derived from snoRNAs have been observed. [6] In recent years, a number of small RNA molecules derived from snoRNAs have been observed. [7]背景 越来越多的证据表明，tRF（tRNA 衍生的小 RNA 片段）和 tiRNA（tRNA 衍生的应激诱导 RNA）是一种新兴的源自转移 RNA (tRNA) 的调节 RNA 分子，在各种人类癌症类型和发挥关键作用。 [1] 细菌使用来自 CRISPR 片段的 RNA 分子以及许多 CRISPR 相关 (Cas) 酶来识别外源 DNA 并将其分开。 [2] nan [3] 摘要 转移 RNA 片段 (tRF) 是一类新兴的小 RNA 分子，来源于成熟或前体 tRNA。 [4] 尊敬的编辑，环状 RNA（circRNA）是通过“反向剪接”从数千个蛋白质编码基因中获得的共价闭合 RNA 分子。 [5] 近年来，已观察到许多源自 snoRNA 的小 RNA 分子。 [6] nan [7]
Complex Molecules Derived 衍生的复杂分子
These include complex molecules derived from natural products or drugs, such as colchicine, taxol, tamiflu, and arachidonic acid. [1] The reactions proceeded efficiently to provide synthetically useful γ,γ-diaryl esters in moderate to good yields, which could be applied to the functionalization of complex molecules derived from bioactive fenofibrate and isoxepac and the synthesis of a precursor of Zoloft. [2] We therefore recommend that biopharmaceuticals are defined as complex molecules derived from a biological source, with the purpose to diagnose, prevent, treat, or cure diseases or conditions of human beings. [3] The strategy might one day expand the range of complex molecules derived from petroleum feedstocks. [4]这些包括源自天然产物或药物的复杂分子，例如秋水仙碱、紫杉醇、达菲和花生四烯酸。 [1] 该反应有效地进行，以中等至良好的收率提供合成有用的 γ,γ-二芳基酯，可应用于衍生自生物活性非诺贝特和异恶唑的复杂分子的官能化以及唑洛夫特前体的合成。 [2] 因此，我们建议将生物药物定义为源自生物来源的复杂分子，其目的是诊断、预防、治疗或治愈人类的疾病或病症。 [3] 该策略有朝一日可能会扩大源自石油原料的复杂分子的范围。 [4]
New Molecules Derived 新分子衍生
¶In order to still allow the use of these products, we theoretically proposed new molecules derived from it. [1] In this review, we will illustrate our efforts in developing new molecules derived from Brazilian cashew nut shell liquid (CNSL), a natural oil and a byproduct of cashew nut food processing, with a high content of phenolic lipids. [2] Other studies on other cardenolides and substances related issues, as well as the development of new molecules derived from OUA, could also be useful in general oxidative and/or cellular stress, a condition favoring the appearance of neuronal pathologies. [3]¶为了仍然允许使用这些产品，我们理论上提出了从中衍生的新分子。 [1] 在这篇综述中，我们将说明我们在开发源自巴西腰果壳液 (CNSL) 的新分子方面所做的努力，CNSL 是一种天然油，是腰果食品加工的副产品，具有高含量的酚类脂质。 [2] nan [3]
Signalling Molecules Derived
Numerous signalling molecules derived from gut microbiota, such as by-products of microbiota, metabolites, neurotransmitters, and neuromodulators, act on their receptors and remarkably regulate the peripheral and central sensitisation, which in turn mediate the development of chronic pain. [1] Endogenous cannabinoids are lipid-signalling molecules derived from arachidonic acid involved in the pathogenesis of cardiovascular dysfunction, portal hypertension, liver fibrosis, and other processes associated with hepatic disease through their interactions with the CB1 and CB2 receptors. [2]来自肠道微生物群的许多信号分子，如微生物群的副产物、代谢物、神经递质和神经调节剂，作用于它们的受体并显着调节外周和中枢敏化，进而介导慢性疼痛的发展。 [1] 内源性大麻素是源自花生四烯酸的脂质信号分子，通过它们与 CB1 和 CB2 受体的相互作用，参与心血管功能障碍、门静脉高压症、肝纤维化和其他与肝病相关的过程的发病机制。 [2]
Reactive Molecules Derived
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules derived from molecular oxygen. [1] Reactive oxygen species (ROS), such as hydroxyl and superoxide anion radicals, are highly reactive molecules derived from the metabolism of oxygen. [2]nan [1] 活性氧 (ROS)，如羟基和超氧阴离子自由基，是源自氧代谢的高活性分子。 [2]
Specific Molecules Derived
The expressions and locations of TLRs are regulated in response to specific molecules derived from pathogens or damaged host cells. [1] The expressions and locations of TLRs are regulated in response to specific molecules derived from pathogens or damaged host cells. [2]TLR 的表达和位置受到来自病原体或受损宿主细胞的特定分子的调节。 [1] nan [2]
Three Molecules Derived 三个分子衍生
In the present work three molecules derived from natural products were employed as lead molecules for the synthesis of self-assembled nanoparticles. [1] In all the tested configurations, the adsorption of three molecules derived on the removal of the Ni as NiH6. [2]在目前的工作中，三种源自天然产物的分子被用作合成自组装纳米粒子的先导分子。 [1] 在所有测试的配置中，三个分子的吸附源自 Ni 作为 NiH6 的去除。 [2]
Key Molecules Derived 衍生的关键分子
HERG is a key cell membrane glycoprotein; however, whether the maturation process of HERG protein involves key molecules derived from the calnexin (CNX)/calreticulin (CRT) cycle and how these molecules work remains unknown. [1] Epigallocatechin gallate (EGCG) and theaflavins (TFs), key molecules derived from green tea or black tea, have been shown to exert preventive effects on many ageing-related diseases. [2]HERG是一种关键的细胞膜糖蛋白；然而，HERG蛋白的成熟过程是否涉及源自钙连接蛋白（CNX）/钙网蛋白（CRT）循环的关键分子以及这些分子如何发挥作用仍然未知。 [1] 表没食子儿茶素没食子酸酯 (EGCG) 和茶黄素 (TFs) 是源自绿茶或红茶的关键分子，已被证明对许多与衰老相关的疾病具有预防作用。 [2]