Lung Model
肺模型

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Lung Model sentence examples within high flow nasal

high flow nasal

This study describes the effect of high‐frequency oscillation on airway pressure generated by high flow nasal cannula (HFNC) in a premature infant lung model.

本研究描述了高频振荡对早产儿肺模型中高流量鼻导管 (HFNC) 产生的气道压力的影响。

Effect of high‐frequency oscillation on pressure delivered by high flow nasal cannula in a premature infant lung model

high flow nasal

To quantify aerosol delivery with or without a high flow nasal cannula (HFNC) in place using pressurized metered‐dose inhaler (pMDI) and jet nebulizer (JN) with facemask in a simulated spontaneously breathing pediatric lung model.

在模拟自主呼吸的儿科肺模型中，使用加压计量吸入器 (pMDI) 和带面罩的喷射雾化器 (JN) 量化有或没有高流量鼻导管 (HFNC) 的气溶胶输送。

In vitro evaluation of aerosol drug delivery with and without high flow nasal cannula in children

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Lung Model sentence examples within isolated perfused rat

isolated perfused rat
离体灌注大鼠

Lung IR was induced in an isolated perfused rat lung model.

在分离的灌注大鼠肺模型中诱导肺IR。

Protease-Activated Receptor-1 Antagonist Protects Against Lung Ischemia/Reperfusion Injury

isolated perfused rat
离体灌注大鼠

Methods: IR-mediated acute lung inflammation was induced by ischemia for 40 min followed by reperfusion for 60 min in an isolated, perfused rat lung model.

方法：IR 介导的急性肺部炎症通过缺血诱导 40 分钟，然后再灌注 60 分钟，在离体的灌注大鼠肺模型中。

2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression

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Lung Model sentence examples within whole body plethysmography

whole body plethysmography
全身体积描记法

Here, we designed an artificial lung model that enables a thorough evaluation of different predictions about and around whole-body plethysmography.

在这里，我们设计了一个人工肺模型，可以对全身体积描记法的不同预测进行全面评估。

Evaluation of a mechanical lung model to test small animal whole body plethysmography

whole body plethysmography
全身体积描记法

Although frequently used, there is ongoing debate about what exactly is measured by whole-body-plethysmography and how reliable the data derived from this method are? Here, we designed a simple device that can serve as an artificial lung model that enables a thorough evaluation of different predictions about and around whole-body plethysmography.

尽管经常使用，但关于全身体积描记法究竟测量了什么以及从这种方法得出的数据的可靠性如何，一直存在争议？在这里，我们设计了一个简单的设备，可以用作人工肺模型，可以对全身体积描记法的不同预测进行全面评估。

Whole-body plethysmography revisited

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Lung Model sentence examples within Vitro Lung Model

Vitro Lung Model
体外肺模型

Current in vitro lung models focus on modelling the lung epithelium such as air-liquid interface (ALI) cultures and bronchospheres, do not model the complex morphology and the cell-ECM interaction seen in vivo.

目前的体外肺模型侧重于对肺上皮细胞进行建模，例如气液界面 (ALI) 培养物和支气管球，而不是对体内观察到的复杂形态和细胞-ECM 相互作用进行建模。

Epithelial-Stromal Cell Interactions and ECM Mechanics Drive the Formation of Airway-Mimetic Tubular Morphology in Lung Organoids

Vitro Lung Model
体外肺模型

Undeniably, there still remains a recognized trade-off between the physiological and biological complexity of these in vitro lung models and their ability to deliver assays with throughput capabilities.

不可否认，在这些体外肺模型的生理和生物学复杂性与它们提供具有通量能力的检测能力之间仍然存在公认的权衡。

Advanced human-relevant in vitro pulmonary platforms for respiratory therapeutics.

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Lung Model sentence examples within Rat Lung Model

Rat Lung Model
大鼠肺模型

Lung IR was induced in an isolated perfused rat lung model.

在分离的灌注大鼠肺模型中诱导肺IR。

Protease-Activated Receptor-1 Antagonist Protects Against Lung Ischemia/Reperfusion Injury

Rat Lung Model
大鼠肺模型

Methods: IR-mediated acute lung inflammation was induced by ischemia for 40 min followed by reperfusion for 60 min in an isolated, perfused rat lung model.

方法：IR 介导的急性肺部炎症通过缺血诱导 40 分钟，然后再灌注 60 分钟，在离体的灌注大鼠肺模型中。

2-Methoxyestradiol Protects Against Lung Ischemia/Reperfusion Injury by Upregulating Annexin A1 Protein Expression

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Lung Model sentence examples within 3d Lung Model

3d Lung Model

Different diagnostic data – MRI, CT-angiography, and ultrasound – are used in the multidisciplinary study of the lungs, which need to be combined in a single 3D lung model.

不同的诊断数据——MRI、CT 血管造影和超声——用于肺部的多学科研究，需要在单个 3D 肺模型中组合。

Noisy Medical Images Aggregation for Pulmonary Tissue Damage Detection

3d Lung Model

The 3D lung model is a useful tool for toxicological evaluation of cigarette smoke and e‐cigarette aerosol.

3D肺模型是香烟烟雾和电子烟气溶胶毒理学评估的有用工具。

Toxicological comparison of cigarette smoke and e‐cigarette aerosol using a 3D in vitro human respiratory model

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Lung Model sentence examples within Porcine Lung Model

Porcine Lung Model

This experimental work investigated the effects of a neodymium:yttrium aluminum garnet (Nd:YAG) laser on the visceral pleura in an ex vivo porcine lung model.

这项实验工作在离体猪肺模型中研究了钕：钇铝石榴石 (Nd:YAG) 激光对内脏胸膜的影响。

Diode-pumped neodymium:yttrium aluminum garnet laser effects on the visceral pleura in an ex vivo porcine lung model†.

Porcine Lung Model

CONCLUSIONS The ApGltn sealant showed higher adhesive quality and conformability than the fibrin sealant in an excised porcine lung model.

结论 ApGltn 密封剂在切除的猪肺模型中显示出比纤维蛋白密封剂更高的粘合质量和适形性。

Novel Alaska Pollock Gelatin Sealant Shows High Adhesive Quality and Conformability.

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Lung Model sentence examples within Adult Lung Model

Adult Lung Model
成人肺模型

The aim of this study was to evaluate the efficiency of aerosol devices in a simulated COPD adult lung model using five commercially available hand-held mesh nebulizers.

本研究的目的是评估气溶胶装置在模拟 COPD 成人肺模型中使用五种市售手持式网状雾化器的效率。

In Vitro Evaluation of Aerosol Delivery by Hand-Held Mesh Nebulizers in an Adult Spontaneous Breathing Lung Model.

Adult Lung Model
成人肺模型

What is the delivered dose with jet and mesh nebulisers during spontaneous breathing (SB), noninvasive ventilation (NIV), and mechanical ventilation (MV) using an adult lung model with exhaled humidity (EH)? The delivery of salbutamol sulfate (2.

使用具有呼出湿度 (EH) 的成人肺模型在自主呼吸 (SB)、无创通气 (NIV) 和机械通气 (MV) 期间，喷射和网状雾化器的输送剂量是多少？硫酸沙丁胺醇 (2.

Delivered dose with jet and mesh nebulisers during spontaneous breathing, noninvasive ventilation and mechanical ventilation using adult lung models

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Lung Model sentence examples within Test Lung Model

Test Lung Model

Methods: An adult airway and test lung model were exposed to nebulized ‘coarse’ aerosol droplets (0.

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Assessment of mask efficiency for preventing transmission of airborne illness through aerosols and water vapor

Test Lung Model

MethodsFive ventilators set in pressure support mode were tested using a two-chamber test lung model simulating spontaneous breathing.

方法采用模拟自主呼吸的两腔肺试验模型对5台处于压力支持模式的呼吸机进行测试。

Accuracy of P0.1 measurements performed by ICU ventilators: a bench study

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Lung Model sentence examples within Stochastic Lung Model

Stochastic Lung Model

We did the following investigations: particle size analysis, morphology, density, interparticular interactions, crystallinity, in vitro dissolution, in vitro permeability, in vitro aerodynamics (Andersen cascade impactor), and in silico aerodynamics (stochastic lung model).

nan

Formulation and In Vitro and In Silico Characterization of “Nano-in-Micro” Dry Powder Inhalers Containing Meloxicam

Stochastic Lung Model

Potential dose metrics for the estimation of health effects including mass deposition fractions, mass deposition rates and mass deposition density rates were computed with a stochastic lung model based on the measured size distribution of elemental aerosols in the industrial area of Samalut in El-Minia (Egypt).

用于估计健康影响的潜在剂量指标，包括质量沉积分数、质量沉积率和质量沉积密度率，使用随机肺模型计算，该模型基于在 El-Minia 的 Samalut 工业区（埃及）测量的元素气溶胶尺寸分布）。

Prediction of Potential Dose Metrics for the Estimation of Health Effects due to Occupational Exposure in Samalut city, Egypt

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Lung Model sentence examples within Infant Lung Model

Infant Lung Model

The purpose of this study was to determine the effect of nebulizer type, delivery interface, and flow rate on aerosol drug delivery to spontaneously breathing pediatric and infant lung models.

本研究的目的是确定雾化器类型、输送界面和流速对气溶胶药物输送到自主呼吸儿科和婴儿肺模型的影响。

Effect of nebulizer type, delivery interface, and flow rate on aerosol drug delivery to spontaneously breathing pediatric and infant lung models

Infant Lung Model

This study describes the effect of high‐frequency oscillation on airway pressure generated by high flow nasal cannula (HFNC) in a premature infant lung model.

本研究描述了高频振荡对早产儿肺模型中高流量鼻导管 (HFNC) 产生的气道压力的影响。

Effect of high‐frequency oscillation on pressure delivered by high flow nasal cannula in a premature infant lung model

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Lung Model sentence examples within Human Lung Model

Human Lung Model
人肺模型

The efficacy of analogue 6h was also determined in a validated human lung model of TGF-β1-dependent fibrogenesis.

类似物 6h 的功效也在经验证的 TGF-β1 依赖性纤维化人肺模型中确定。

Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.

Human Lung Model
人肺模型

Here, we describe a human lung model, which consisted of a bioprinted base of primary human lung fibroblasts together with monocytic THP-1 cells, on top of which alveolar epithelial A549 cells were printed.

在这里，我们描述了一个人肺模型，该模型由原代人肺成纤维细胞的生物打印基础和单核 THP-1 细胞组成，在其上打印肺泡上皮 A549 细胞。

Bioprinted Multi-Cell Type Lung Model for the Study of Viral Inhibitors

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Lung Model sentence examples within Multiscale Lung Model

Multiscale Lung Model

In this chapter, we review the current state of in silico tools for lung deposition applications and discuss how knowledge gathered from recent studies can be purposefully leveraged to design efficient hybrid multiscale lung models.

在本章中，我们回顾了用于肺沉积应用的计算机工具的现状，并讨论了如何有目的地利用从最近研究中收集的知识来设计高效的混合多尺度肺模型。

In silico methods to model dose deposition

Multiscale Lung Model

Here, we discuss how knowledge gathered from recent in silico studies can be purposefully leveraged to design efficient hybrid multiscale lung models and explore quantitatively via computational fluid-particle dynamics inhalation therapy outcomes.

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Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery

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Lung Model sentence examples within Anatomical Lung Model

Anatomical Lung Model

We evaluate this approach using simulation-based studies in anatomical lung models.

我们在解剖肺模型中使用基于模拟的研究来评估这种方法。

Backward Planning for a Multi-Stage Steerable Needle Lung Robot

Anatomical Lung Model

Patient-specific anatomical lung models, with various geometries and locations of tumors, were developed for further evaluation of device performance and treatment strategies.

nan

Endobronchial high-intensity ultrasound for thermal therapy of pulmonary malignancies: simulations with patient-specific lung models

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Lung Model sentence examples within Computational Lung Model

Computational Lung Model

METHODS AND RESULTS Applying a high-resolution computational lung modeling technique in a preterm infant, we studied three different high-frequency ventilation settings as well as conventional ventilation (CV) settings.

In silico numerical simulation of ventilator settings during high-frequency ventilation in preterm infants.

Computational Lung Model

In this study, we developed a computational lung model with mechanical properties consistent with healthy and PBLI conditions.

Computational Modeling of Primary Blast Lung Injury: Implications for Ventilator Management.

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Lung Model sentence examples within Breathing Lung Model

Breathing Lung Model

We demonstrate Endoscopic Optical Coherence Elastography (Endo-OCE) imaging of bronchus in an artificial breathing lung model that can breathe at 10 times per minute with a tidal volume of 500 ml.

Capturing the breath of an artificial lung model using endoscopic optical coherence elastography

Breathing Lung Model

Objective To describe the effective pressure and FiO2 delivery to a realistic spontaneously breathing lung model using a novel, simple, inexpensive neonatal non-invasive bubble continuous positive airway pressure (CPAP) device.

Simple point of care continuous positive airway pressure delivery device (Jain-CPAP)

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Lung Model sentence examples within Pig Lung Model

Pig Lung Model

We have previously described an ex vivo pig lung model (EVPL) of cystic fibrosis for Pseudomonas aeruginosa lung infection.

我们之前已经描述了用于铜绿假单胞菌肺部感染的囊性纤维化的离体猪肺模型 (EVPL)。

Of mice or men? Developing an ex vivo model of Staphylococcus aureus infection in the cystic fibrosis lung

Pig Lung Model

Here, we present details of the development of an existing ex vivo pig lung model of CF infection to investigate the growth of S.

在这里，我们介绍了现有的 CF 感染体外猪肺模型的开发细节，以研究 S.

An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection

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Lung Model sentence examples within Mouse Lung Model

Mouse Lung Model

The chimerism of the human-mouse lung model indicated that DASC pedigrees could give rise to multiple epithelial types, including type I alveolar cells as well as bronchiolar secretory cells, to regenerate the distal lung.

Stable Long-Term Culture of Human Distal Airway Stem Cells for Transplantation

Mouse Lung Model

The lung fixation method presented here utilizes constant pressure to enable optimal tissue evaluation for studies using an emphysematous mouse lung model.

Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice.

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Lung Model sentence examples within Ventilation Lung Model

Ventilation Lung Model

A single-compartment tidal-ventilation lung model processes the amplitude/phase of the expired N2O sinewave and estimates cardiopulmonary variables including: effective lung volume and indices of ventilatory heterogeneity (VH; ELV180/FRCpleth and ELV180/ELVpred).

Assessment of Ventilatory Heterogeneity in Chronic Obstructive Pulmonary Disease Using the Inspired Sinewave Test

Ventilation Lung Model

Q˙IST was determined in a single-compartment tidal ventilation lung model that used the resulting amplitude/phase of the expired N2O sinewave.

Noninvasive cardiac output monitoring in a porcine model using the inspired sinewave technique: a proof-of-concept study

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Lung Model sentence examples within Geometric Lung Model

Geometric Lung Model

In addition to 3D geometric lung models, matching detailed relative particle deposition measurements are provided.

除了 3D 几何肺模型外，还提供了匹配的详细相对颗粒沉积测量。

lapdMouse: associating lung anatomy with local particle deposition in mice.

Geometric Lung Model

Based on retrospective data, this study evaluates different geometric lung models in their ability to deliver accurate tidal volumes from changes in thoracic and abdominal circumference.

基于回顾性数据，本研究评估了不同几何肺模型根据胸围和腹围变化提供准确潮气量的能力。

Tidal volume via circumferences of the upper body: a pilot study

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Lung Model sentence examples within Pediatric Lung Model

Pediatric Lung Model

This study aims to determine the aerosol deposition with jet (JN) and mesh nebulizers (MN) during SB, NIV, and MV using a pediatric lung model.

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Quantifying Delivered Dose with Jet and Mesh Nebulizers during Spontaneous Breathing, Noninvasive Ventilation, and Mechanical Ventilation in a Simulated Pediatric Lung Model with Exhaled Humidity

Pediatric Lung Model

To quantify aerosol delivery with or without a high flow nasal cannula (HFNC) in place using pressurized metered‐dose inhaler (pMDI) and jet nebulizer (JN) with facemask in a simulated spontaneously breathing pediatric lung model.

在模拟自主呼吸的儿科肺模型中，使用加压计量吸入器 (pMDI) 和带面罩的喷射雾化器 (JN) 量化有或没有高流量鼻导管 (HFNC) 的气溶胶输送。

In vitro evaluation of aerosol drug delivery with and without high flow nasal cannula in children

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Lung Model sentence examples within Simple Lung Model

Simple Lung Model

Furthermore, the calculation results using the CFD−DEM simulation quantitatively demonstrated the higher particle reachability into the simple lung model when smaller particles were used.

Numerical Simulation of Particle Motions in Cascade Impactor and Human Respiratory System

Simple Lung Model

In this paper, we propose to use finite element method (FEM) to simulate the microwave ablation for lung cancer in a simple lung model.

Numerical Study for Lung Microwave Ablation in Different Thermal and Electrical Properties

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Lung Model sentence examples within Vascular Lung Model

Vascular Lung Model
血管肺模型

We demonstrate using in silico and an in vitro 3D-human vascular lung model which profiles anti-inflammatory and anti-thrombogenic properties that all four TKI’s are active in varying degrees.

我们展示了使用计算机和体外 3D 人血管肺模型，该模型描述了所有四种 TKI 在不同程度上具有活性的抗炎和抗血栓形成特性。

Tyrosine Kinase Inhibitor Family of Drugs as Prospective Targeted Therapy for COVID-19 Based on In Silico And 3D-Human Vascular Lung Model Studies

Vascular Lung Model
血管肺模型

While we prioritized a few antiviral drugs based on molecular docking, corroboration with in vitro studies including a new 3D human vascular lung model strongly supported the potential of Homoharringtonine, a drug approved for chronic myeloid leukaemia to be repurposed for COVID-19.

虽然我们优先考虑了一些基于分子对接的抗病毒药物，但体外研究的证实，包括一种新的 3D 人血管肺模型，有力地支持了 Homoharringtonine 的潜力，这种药物被批准用于慢性粒细胞白血病，可重新用于 COVID-19。

In silico and in vitro Demonstration of Homoharrintonine’s Antagonism of RBD-ACE2 Binding and its Anti-inflammatory and anti-thrombogenic Properties in a 3D human vascular lung model

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Lung Model sentence examples within Animal Lung Model

Animal Lung Model
动物肺模型

in ventilated animal lung model may increase the risk of inflammation and subsequent damage in healthy lungs, these findings may help physicians to avoid using high Vt.

在通气动物肺模型中可能会增加健康肺部炎症和随后损伤的风险，这些发现可能有助于医生避免使用高 Vt。

The effect of low versus high tidal volume ventilation on inflammatory markers in animal model undergoing lung ventilation: A prospective study

Animal Lung Model
动物肺模型

It seems to us that if such animal lung models are to mean much beyond investigation of nonspecific immune/inflammatory responses, then they really need to look at least approximately like the human pulmonary disease in question, reflecting specific pathology.

在我们看来，如果这种动物肺模型的意义远远超出了对非特异性免疫/炎症反应的研究，那么它们确实需要看起来至少近似于所讨论的人类肺部疾病，反映特定的病理学。

Silicosis: Pathogenesis and utility of animal models of disease

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Lung Model sentence examples within Mechanical Lung Model

Mechanical Lung Model
机械肺模型

Tidal volumes, 4-point sealing forces of the mask, peak pressure, and C length of the C shape in the one-hand EC grip were measured using the mechanical lung model under a simulated adult respiratory arrest.

潮气量、面罩的 4 点密封力、峰值压力和单手 EC 握把中 C 形的 C 长度在模拟成人呼吸停止下使用机械肺模型进行测量。

Tidal volume according to the 4-point sealing forces of a bag-valve-mask: an adult respiratory arrest simulator-based prospective, descriptive study

Mechanical Lung Model
机械肺模型

Tidal volumes, 4-point sealing forces of the mask, peak pressure, and C length of the C shape in the one-hand EC grip, were measured using the mechanical lung model under a simulated adult respiratory arrest.

在模拟成人呼吸停止的情况下，使用机械肺模型测量潮气量、面罩的 4 点密封力、峰值压力和 C 形单手握把的 C 长度。

Study on Tidal Volume According to the 4-Point Sealing Forces of Bag-Valve-Mask : An Adult Respiratory Arrest Simulator Based Prospective, Descriptive Study

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Lung Model sentence examples within Artificial Lung Model

Artificial Lung Model
人工肺模型

Here, we designed an artificial lung model that enables a thorough evaluation of different predictions about and around whole-body plethysmography.

在这里，我们设计了一个人工肺模型，可以对全身体积描记法的不同预测进行全面评估。

Evaluation of a mechanical lung model to test small animal whole body plethysmography

Artificial Lung Model
人工肺模型

Although frequently used, there is ongoing debate about what exactly is measured by whole-body-plethysmography and how reliable the data derived from this method are? Here, we designed a simple device that can serve as an artificial lung model that enables a thorough evaluation of different predictions about and around whole-body plethysmography.

尽管经常使用，但关于全身体积描记法究竟测量了什么以及从这种方法得出的数据的可靠性如何，一直存在争议？在这里，我们设计了一个简单的设备，可以用作人工肺模型，可以对全身体积描记法的不同预测进行全面评估。

Whole-body plethysmography revisited

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10.1016/j.resp.2021.103738

RESULTS During assisted ventilation, the respiratory system compliance (Crs) calculation was always overestimated in most lung models.

结果 在辅助通气期间，呼吸系统顺应性 (Crs) 计算在大多数肺模型中总是被高估。

Continuous estimation of airway resistance in non-invasive ventilation

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10.1109/ICACCS51430.2021.9441702

It was observed that deep transfer learning based CNNs such as the Xception network and Inception-ResNet50v2 network can differentiate benign and malignant nodules in a better manner when compared to the ConvLung model.

据观察，与 ConvLung 模型相比，基于深度迁移学习的 CNN（例如 Xception 网络和 Inception-ResNet50v2 网络）可以更好地区分良性和恶性结节。

Lung Nodule Classification using Shallow CNNs and Deep Transfer Learning CNNs

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10.4187/respcare.08749

Parameters of the lung models used for simulations (resistance and compliance) were evidence-based from published studies.

用于模拟的肺模型参数（阻力和顺应性）是基于已发表研究的证据。

Multiplex Ventilation: Solutions for Four Main Safety Problems

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10.1109/TBME.2021.3053321

In this paper, the lung model is monitored and controlled by a personalized lung pressure/volume relationship during a whole respiratory cycle.

在本文中，肺模型在整个呼吸周期中通过个性化的肺压力/容积关系进行监测和控制。

Towards Non-Invasive Lung Tumor Tracking Based on Patient Specific Model of Respiratory System

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10.3390/jcm10112336

Subjects: We set the lung model with three conditions of resistance and linear compliance for mimicking different respiratory mechanics of representative intensive care unit (ICU) patients.

主题：我们设置了具有阻力和线性顺应性三个条件的肺模型，以模拟具有代表性的重症监护病房 (ICU) 患者的不同呼吸力学。

The eSpiro Ventilator: An Open-Source Response to a Worldwide Pandemic

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10.24018/ejphysics.2021.3.5.97

The minimum uncertainty attainable in the stochastic Madelung model is shown to be compatible with maximum speed of transmission of information and interactions.

随机马德隆模型中可达到的最小不确定性被证明与信息和交互的最大传输速度兼容。

Stability of Quantum Eigenstates and Collapse of Superposition of States in a Fluctuating Vacuum: The Madelung Hydrodynamic Approach

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10.3390/bios11060176

Through simulation and in vitro experiment, it is demonstrated that the proposed fusion method can reasonably reconstruct both the bio- and non-conductive inclusions within the lung models established to simulate the ventilation process, which is expected to be beneficial for the diagnosis of lung-tissue related diseases by EIT.

通过模拟和体外实验证明，所提出的融合方法可以合理地重建为模拟通气过程而建立的肺模型中的生物和非导电包涵体，有望对肺脏疾病的诊断有所帮助。 EIT的组织相关疾病。

Simultaneous Imaging of Bio- and Non-Conductive Targets by Combining Frequency and Time Difference Imaging Methods in Electrical Impedance Tomography

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10.1101/2021.07.16.452691

Here, we show for the first time the temporal development of lung cell lineages using hPSC that model developmental milestones observed in primary tissue, the generation of renewable fetal lung epithelial spheroids, and the functional utility of the lung models at different differentiation stages for Cystic fibrosis disease modeling.

在这里，我们首次展示了使用 hPSC 模拟在原发组织中观察到的发育里程碑、可再生胎儿肺上皮球体的生成以及肺模型在不同分化阶段对囊性纤维化的功能效用的肺细胞谱系的时间发育疾病建模。

Modeling lung cell development using human pluripotent stem cells

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10.21203/rs.3.rs-753708/v1

Here, we show for the first time the temporal development of lung cell lineages using hPSC that model developmental milestones observed in primary tissue, the generation of renewable fetal lung epithelial spheroids, and the functional utility of the lung models at different differentiation stages for Cystic fibrosis disease modeling.

在这里，我们首次展示了使用 hPSC 模拟在原发组织中观察到的发育里程碑、可再生胎儿肺上皮球体的生成以及肺模型在不同分化阶段对囊性纤维化的功能效用的肺细胞谱系的时间发育疾病建模。

Modeling lung cell development using human pluripotent stem cells

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10.1016/j.jaerosci.2020.105623

It is even more challenging to study variability in inhalation dosimetry or pulmonary drug delivery, which requires a large cohort of lung models to ensure statistically significant results.

研究吸入剂量测定或肺部药物输送的变异性更具挑战性，这需要大量肺模型来确保具有统计学意义的结果。

The application of statistical shape modeling for lung morphology in aerosol inhalation dosimetry

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10.1007/s10851-020-01006-y

The system of equations is implemented numerically for a two dimensional scenario and the algorithm is tested on two different numerical phantoms, a heart and lung model and a human brain model.

方程组是针对二维场景以数值方式实现的，并且该算法在两个不同的数值模型上进行了测试，即心肺模型和人脑模型。